Zobrazeno 1 - 10
of 2 031
pro vyhledávání: '"Forest M"'
Autor:
Heba Alkhatib, Jason Conage-Pough, Sangita Roy Chowdhury, Denen Shian, Deema Zaid, Ariel M. Rubinstein, Amir Sonnenblick, Tamar Peretz-Yablonsky, Avital Granit, Einat Carmon, Ishwar N. Kohale, Judy C. Boughey, Matthew P. Goetz, Liewei Wang, Forest M. White, Nataly Kravchenko-Balasha
Publikováno v:
Molecular Cancer, Vol 23, Iss 1, Pp 1-7 (2024)
Abstract Triple negative breast cancer (TNBC) is a heterogeneous group of tumors which lack estrogen receptor, progesterone receptor, and HER2 expression. Targeted therapies have limited success in treating TNBC, thus a strategy enabling effective ta
Externí odkaz:
https://doaj.org/article/6e9c5a225b574c2e9c271b3e30c7bf17
Autor:
J. Bryan Iorgulescu, Neil Ruthen, Ryuhjin Ahn, Eleni Panagioti, Prafulla C. Gokhale, Martha Neagu, Maria C. Speranza, Benjamin K. Eschle, Kara M. Soroko, Raziye Piranlioglu, Meenal Datta, Shanmugarajan Krishnan, Kathleen B. Yates, Gregory J. Baker, Rakesh K. Jain, Mario L. Suvà, Donna Neuberg, Forest M. White, E. Antonio Chiocca, Gordon J. Freeman, Arlene H. Sharpe, Catherine J. Wu, David A. Reardon
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundThe GL261 and CT2A syngeneic tumor lines are frequently used as immunocompetent orthotopic mouse models of human glioblastoma (huGBM) but demonstrate distinct differences in their responses to immunotherapy.MethodsTo decipher the cell-intri
Externí odkaz:
https://doaj.org/article/0d4ef411871943b490bc6d2c4f558fb2
Autor:
Brendan L. Horton, Alicia D. D’Souza, Maria Zagorulya, Chloe V. McCreery, Gita C. Abhiraman, Lora Picton, Allison Sheen, Yash Agarwal, Noor Momin, K. Dane Wittrup, Forest M. White, K. Christopher Garcia, Stefani Spranger
Publikováno v:
JCI Insight, Vol 8, Iss 19 (2023)
Engineered cytokine–based approaches for immunotherapy of cancer are poised to enter the clinic, with IL-12 being at the forefront. However, little is known about potential mechanisms of resistance to cytokine therapies. We found that orthotopic mu
Externí odkaz:
https://doaj.org/article/e315efdb0cc249018ebbc3ca54aedce4
Publikováno v:
eLife, Vol 12 (2023)
CD8+ T cell recognition of Mycobacterium tuberculosis (Mtb)-specific peptides presented on major histocompatibility complex class I (MHC-I) contributes to immunity to tuberculosis (TB), but the principles that govern presentation of Mtb antigens on M
Externí odkaz:
https://doaj.org/article/6ee539ff7393483e9d4099c3c903a4d5
Autor:
Walid M. Abdelmoula, Begona Gimenez-Cassina Lopez, Elizabeth C. Randall, Tina Kapur, Jann N. Sarkaria, Forest M. White, Jeffrey N. Agar, William M. Wells, Nathalie Y. R. Agar
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
The high dimensional and complex nature of mass spectrometry imaging (MSI) data poses challenges to downstream analyses. Here the authors show an application of artificial intelligence in mining MSI data revealing biologically relevant metabolomic an
Externí odkaz:
https://doaj.org/article/9244c823f02b459a98d698b08982a133
Autor:
Lauren E. Stopfer, Joshua M. Mesfin, Brian A. Joughin, Douglas A. Lauffenburger, Forest M. White
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Immunopeptidomics allows identifying the cellular repertoire of MHC-bound peptides, but quantifying them remains challenging. Here, the authors present a method to efficiently generate internal peptide MHC standards and calibration curves, facilitati
Externí odkaz:
https://doaj.org/article/a31704ed76cf4812b9becfece7121839
Autor:
Ana Victoria C. Pilar, Nicholas Petronella, Forest M. Dussault, Adrian J. Verster, Sadjia Bekal, Roger C. Levesque, Lawrence Goodridge, Sandeep Tamber
Publikováno v:
BMC Genomics, Vol 21, Iss 1, Pp 1-13 (2020)
Abstract Background Salmonella enterica is a leading cause of foodborne illness worldwide resulting in considerable public health and economic costs. Testing for the presence of this pathogen in food is often hampered by the presence of background mi
Externí odkaz:
https://doaj.org/article/74ad4e3053ba4cffb0a88f0d0f2cf08e
Autor:
Forest M. Altherr, Andrew W. Nute, Mulat Zerihun, Eshetu Sata, Aisha E. P. Stewart, Demelash Gessese, Berhanu Melak, Tigist Astale, Gedefaw Ayenew, E. Kelly Callahan, Melsew Chanyalew, Bizuayehu Gashaw, Lance A. Waller, Zerihun Tadesse, Scott D. Nash
Publikováno v:
Parasites & Vectors, Vol 12, Iss 1, Pp 1-11 (2019)
Abstract Background Trachoma is the leading infectious cause of blindness globally. The WHO has recommended the SAFE (Surgery, Antibiotics, Facial cleanliness and Environmental improvements) strategy to eliminate trachoma as a public health problem.
Externí odkaz:
https://doaj.org/article/55863181122f4d86a5205c24314159f3
Autor:
Jamie M. Kelly, Peter D. Ivatt, Mathew J. Evans, Jesse H. Kroll, Amy I. H. Hrdina, Ishwar N. Kohale, Forest M. White, Bevin P. Engelward, Noelle E. Selin
Publikováno v:
GeoHealth, Vol 5, Iss 9, Pp n/a-n/a (2021)
Abstract In assessments of cancer risk from atmospheric polycyclic aromatic hydrocarbons (PAHs), scientists and regulators rarely consider the complex mixture of emitted compounds and degradation products, and they often represent the entire mixture
Externí odkaz:
https://doaj.org/article/9188358648a44ebe856f0fd2242ba486
Publikováno v:
mSystems, Vol 6, Iss 4 (2021)
ABSTRACT T cells must recognize pathogen-derived peptides bound to major histocompatibility complexes (MHCs) in order to initiate a cell-mediated immune response against an infection, or to support the development of high-affinity antibody responses.
Externí odkaz:
https://doaj.org/article/89b3a5ca52984f76adf985d4996a36ae