YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer

Autor: Wenyi Mi, Haipeng Guan, Jie Lyu, Dan Zhao, Yuanxin Xi, Shiming Jiang, Forest H. Andrews, Xiaolu Wang, Mihai Gagea, Hong Wen, Laszlo Tora, Sharon Y. R. Dent, Tatiana G. Kutateladze, Wei Li, Haitao Li, Xiaobing Shi

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)

Histone modification recognition is an important mechanism for gene expression regulation in cancer. Here, the authors identify YEATS2 as a histone H3K27ac reader, regulating a transcriptional program essential for tumorigenesis in human non-small ce

Externí odkaz: https://doaj.org/article/be7fccc0c928460dac1868ae040b124c

Yaf9 subunit of the NuA4 and SWR1 complexes targets histone H3K27ac through its YEATS domain

Autor: Joseph B. Bridgers, Zachary A Mayo, Forest H. Andrews, Brianna J. Klein, Jinyong Zhang, Brian D. Strahl, Kendra R. Vann, Jacques Côté, Salar Ahmad, Gaelle Bourriquen, Tatiana G. Kutateladze

Publikováno v: Nucleic Acids Research

Yaf9 is an integral part of the NuA4 acetyltransferase and the SWR1 chromatin remodeling complexes. Here, we show that Yaf9 associates with acetylated histone H3 with high preference for H3K27ac. The crystal structure of the Yaf9 YEATS domain bound t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc42e11a74bb8ee341c4550da4ca461
https://doi.org/10.1093/nar/gkx1151

Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase

Autor: Ahway Pandey, James C. Costello, Yi Zhang, Tatiana G. Kutateladze, Forest H. Andrews, Qiong Tong, Muzaffar Ali, Angela H. Guo, Scott B. Rothbart, Kelly D. Sullivan, Jae-Woo Ahn, Brian D. Strahl, Evan M. Cornett, Joaquín M. Espinosa

Publikováno v: Cell Reports, Vol 16, Iss 12, Pp 3195-3207 (2016)

MORC3 is linked to inflammatory myopathies and cancer, however the precise role of MORC3 in normal cell physiology and disease remains poorly understood. Here, we present detailed genetic, biochemical, and structural analyses of MORC3. We demonstrate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e8a2dab0f22762daf42d2515162cd5

YEATS2 links histone acetylation to tumorigenesis of non-small cell lung cancer

Autor: Yuanxin Xi, Haitao Li, Wei Li, Shiming Jiang, Forest H. Andrews, Haipeng Guan, Hong Wen, Laszlo Tora, Xiaolu Wang, Dan Zhao, Wenyi Mi, Tatiana G. Kutateladze, Sharon Y.R. Dent, Mihai Gagea, Xiaobing Shi, Jie Lyu

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2017, 8 (1), ⟨10.1038/s41467-017-01173-4⟩
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)

Recognition of modified histones by “reader” proteins constitutes a key mechanism regulating diverse chromatin-associated processes important for normal and neoplastic development. We recently identified the YEATS domain as a novel acetyllysine-b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0d515397f612d4c9c7ceba8ca8ef21e
https://doi.org/10.1038/s41467-017-01173-4

Dual-activity PI3K–BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasis

Autor: Tatiana G. Kutateladze, Forest H. Andrews, Guillermo A. Morales, Donald L. Durden, Alok R. Singh, Cassandra A. Smith, Shweta Joshi, Joseph R. Garlich

Publikováno v: Proceedings of the National Academy of Sciences. 114

MYC is a major cancer driver but is documented to be a difficult therapeutic target itself. Here, we report on the biological activity, the structural basis, and therapeutic effects of the family of multitargeted compounds that simultaneously disrupt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd1dec80076603181918270b6befa112
https://doi.org/10.1073/pnas.1613091114