Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Forde, Thomas P."'
Autor:
K. A. Stark, G. Rinaldi, A. Costain, S. Clare, C. Tolley, A. Almeida, C. McCarthy, K. Harcourt, C. Brandt, T. D. Lawley, M. Berriman, A. S. MacDonald, J. E. Forde-Thomas, B. J. Hulme, K. F. Hoffmann, C. Cantacessi, A. Cortés
Publikováno v:
Animal Microbiome, Vol 6, Iss 1, Pp 1-19 (2024)
Abstract Mounting evidence of the occurrence of direct and indirect interactions between the human blood fluke, Schistosoma mansoni, and the gut microbiota of rodent models raises questions on the potential role(s) of the latter in the pathophysiolog
Externí odkaz:
https://doaj.org/article/00b9a9d991ae49ddba6d0fd576bc8ed2
Autor:
E. L. Houlder, A. H. Costain, I. Nambuya, S. L. Brown, J. P. R. Koopman, M. C. C. Langenberg, J. J. Janse, M. A. Hoogerwerf, A. J. L. Ridley, J. E. Forde-Thomas, S. A. P. Colombo, B. M. F. Winkel, A. A. Galdon, K. F. Hoffmann, P. C. Cook, M. Roestenberg, H. Mpairwe, A. S. MacDonald
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Schistosomiasis, a parasitic helminth infection, causes pulmonary symptoms during acute and chronic infection. Here, Houlder et al characterise the pulmonary immune response and demonstrate the role type 2 dendritic cells play in lung inflammation.
Externí odkaz:
https://doaj.org/article/f2549630402c40a3814cbbc16588cdcc
Autor:
Iain W. Chalmers, Christoph Grunau, Josephine Forde-Thomas, Karl F. Hoffmann, Andrea Brancale, Cassandra A. Celatka, Gilda Padalino, Jay H. Kalin, Hugh Y. Rienhoff Jr., Damien Lassalle, Philip A. Cole
Publikováno v:
Wellcome Open Research, Vol 8 (2023)
Background: Schistosoma mansoni, a parasitic worm species responsible for the neglected tropical disease schistosomiasis, undergoes strict developmental regulation of gene expression that is carefully controlled by both genetic and epigenetic process
Externí odkaz:
https://doaj.org/article/4dd3f4ccaedf4ebd9cfa3454b89491e8
Modified Hederagenin Derivatives Demonstrate Ex Vivo Anthelmintic Activity against Fasciola hepatica
Autor:
Anand Chakroborty, Deiniol R. Pritchard, Marc E. Bouillon, Anna Cervi, Rolf Kraehenbuehl, Charlotte Wild, Caroline Fenn, Peter Holdsworth, Colin Capner, Gilda Padalino, Josephine E. Forde-Thomas, Joseph Payne, Brendan G. Smith, Maggie Fisher, Martina Lahmann, Mark S. Baird, Karl F. Hoffmann
Publikováno v:
Pharmaceutics, Vol 15, Iss 7, p 1869 (2023)
Infection with Fasciola hepatica (liver fluke) causes fasciolosis (or fascioliasis) and poses a considerable economic as well as welfare burden to both the agricultural and animal health sectors. Here, we explore the ex vivo anthelmintic potential of
Externí odkaz:
https://doaj.org/article/6e8ca26b7c334320af200daf96523567
Autor:
Gilda Padalino, Avril Coghlan, Giampaolo Pagliuca, Josephine E. Forde-Thomas, Matthew Berriman, Karl F. Hoffmann
Publikováno v:
Pharmaceutics, Vol 15, Iss 5, p 1359 (2023)
Schistosomiasis is one of the most important neglected tropical diseases. Until an effective vaccine is registered for use, the cornerstone of schistosomiasis control remains chemotherapy with praziquantel. The sustainability of this strategy is at s
Externí odkaz:
https://doaj.org/article/45e27b46d0fb4961ac6c0c9f61f8ecce
Autor:
Benjamin J Hulme, Kathrin K Geyer, Josephine E Forde-Thomas, Gilda Padalino, Dylan W Phillips, Wannaporn Ittiprasert, Shannon E Karinshak, Victoria H Mann, Iain W Chalmers, Paul J Brindley, Cornelis H Hokke, Karl F Hoffmann
Publikováno v:
PLoS Pathogens, Vol 18, Iss 1, p e1009828 (2022)
α-galactosidase (α-GAL) and α-N-acetylgalactosaminidase (α-NAGAL) are two glycosyl hydrolases responsible for maintaining cellular homeostasis by regulating glycan substrates on proteins and lipids. Mutations in the human genes encoding either en
Externí odkaz:
https://doaj.org/article/05828ee02d5c4a1e99b9770422f25c16
Autor:
Thomas A Gasan, Marije E Kuipers, Grisial H Roberts, Gilda Padalino, Josephine E Forde-Thomas, Shona Wilson, Jakub Wawrzyniak, Edridah M Tukahebwa, Karl F Hoffmann, Iain W Chalmers
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 15, Iss 11, p e0009981 (2021)
Extracellular Vesicles (EVs) are an integral component of cellular/organismal communication and have been found in the excreted/secreted (ES) products of both protozoan and metazoan parasites. Within the blood fluke schistosomes, EVs have been isolat
Externí odkaz:
https://doaj.org/article/b2621b7e6e32434c869297e253311374
Akademický článek
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Autor:
Helen Whiteland, Alessandra Crusco, Lisa W Bloemberg, Jamie Tibble-Howlings, Josephine Forde-Thomas, Avril Coghlan, Patrick J Murphy, Karl F Hoffmann
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008630 (2020)
BackgroundSchistosomiasis is a prevalent neglected tropical disease that affects approximately 300 million people worldwide. Its treatment is through a single class chemotherapy, praziquantel. Concerns surrounding the emergence of praziquantel insens
Externí odkaz:
https://doaj.org/article/d85a730237654388acb93a9eb883f7ba
Autor:
Helen L. Whiteland, Anand Chakroborty, Josephine E. Forde-Thomas, Alessandra Crusco, Alan Cookson, Jackie Hollinshead, Caroline A. Fenn, Barbara Bartholomew, Peter A. Holdsworth, Maggie Fisher, Robert J. Nash, Karl F. Hoffmann
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 8, Iss 3, Pp 465-474 (2018)
Two economically and biomedically important platyhelminth species, Fasciola hepatica (liver fluke) and Schistosoma mansoni (blood fluke), are responsible for the neglected tropical diseases (NTDs) fasciolosis and schistosomiasis. Due to the absence o
Externí odkaz:
https://doaj.org/article/d7538bd8d6a54de3a201e4bbc39ca081