Novel series of pyrrolotriazine analogs as highly potent pan-Aurora kinase inhibitors

Autor: Abraham, Sunny, Hadd, Michael J., Tran, Lan, Vickers, Troy, Sindac, Janice, Milanov, Zdravko V., Holladay, Mark W., Bhagwat, Shripad S., Hua, Helen, Ford Pulido, Julia M., Cramer, Merryl D., Gitnick, Dana, James, Joyce, Dao, Alan, Belli, Barbara, Armstrong, Robert C., Treiber, Daniel K., Liu, Gang

Publikováno v: In Bioorganic & Medicinal Chemistry Letters 15 September 2011 21(18):5296-5300

Discovery of AC710, a Globally Selective Inhibitor of Platelet-Derived Growth Factor Receptor-Family Kinases.

Autor: Liu G; Departments of Medicinal Chemistry, Cell Biology and Pharmacology, Technology Development, and DMPK and Toxicology, 4215 Sorrento Valley Boulevard, San Diego, California 92121, United States., Campbell BT; Departments of Medicinal Chemistry, Cell Biology and Pharmacology, Technology Development, and DMPK and Toxicology, 4215 Sorrento Valley Boulevard, San Diego, California 92121, United States., Holladay MW; Departments of Medicinal Chemistry, Cell Biology and Pharmacology, Technology Development, and DMPK and Toxicology, 4215 Sorrento Valley Boulevard, San Diego, California 92121, United States., Ford Pulido JM; Departments of Medicinal Chemistry, Cell Biology and Pharmacology, Technology Development, and DMPK and Toxicology, 4215 Sorrento Valley Boulevard, San Diego, California 92121, United States., Hua H; Departments of Medicinal Chemistry, Cell Biology and Pharmacology, Technology Development, and DMPK and Toxicology, 4215 Sorrento Valley Boulevard, San Diego, California 92121, United States., Gitnick D; Departments of Medicinal Chemistry, Cell Biology and Pharmacology, Technology Development, and DMPK and Toxicology, 4215 Sorrento Valley Boulevard, San Diego, California 92121, United States., Gardner MF; Departments of Medicinal Chemistry, Cell Biology and Pharmacology, Technology Development, and DMPK and Toxicology, 4215 Sorrento Valley Boulevard, San Diego, California 92121, United States., James J; Departments of Medicinal Chemistry, Cell Biology and Pharmacology, Technology Development, and DMPK and Toxicology, 4215 Sorrento Valley Boulevard, San Diego, California 92121, United States., Breider MA; Departments of Medicinal Chemistry, Cell Biology and Pharmacology, Technology Development, and DMPK and Toxicology, 4215 Sorrento Valley Boulevard, San Diego, California 92121, United States., Brigham D; Departments of Medicinal Chemistry, Cell Biology and Pharmacology, Technology Development, and DMPK and Toxicology, 4215 Sorrento Valley Boulevard, San Diego, California 92121, United States., Belli B; Departments of Medicinal Chemistry, Cell Biology and Pharmacology, Technology Development, and DMPK and Toxicology, 4215 Sorrento Valley Boulevard, San Diego, California 92121, United States., Armstrong RC; Departments of Medicinal Chemistry, Cell Biology and Pharmacology, Technology Development, and DMPK and Toxicology, 4215 Sorrento Valley Boulevard, San Diego, California 92121, United States., Treiber DK; Departments of Medicinal Chemistry, Cell Biology and Pharmacology, Technology Development, and DMPK and Toxicology, 4215 Sorrento Valley Boulevard, San Diego, California 92121, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2012 Sep 24; Vol. 3 (12), pp. 997-1002. Date of Electronic Publication: 2012 Sep 24 (Print Publication: 2012).