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Allergic asthma is distinguished by sensitivity of allergen-specific CD4+T cells and airway structural cells to type 2 inflammation

Autor: Cho, Josalyn L., Ling, Morris F., Adams, David C., Faustino, Lucas, Islam, Sabina A., Afshar, Roshi, Griffith, Jason W., Harris, Robert S., Ng, Aylwin, Radicioni, Giorgia, Ford, Amina A., Han, Andre K., Xavier, Ramnik, Kwok, William W., Boucher, Richard, Moon, James J., Hamilos, Daniel L., Kesimer, Mehmet, Suter, Melissa J., Medoff, Benjamin D., Luster, Andrew D.

Publikováno v: Science Translational Medicine; October 2016, Vol. 8 Issue: 359 p359ra132-359ra132, 1p

The innate immune properties of airway mucosal surfaces are regulated by dynamic interactions between mucins and interacting proteins: the mucin interactome.

Autor: Radicioni G; Department of Pathology and Laboratory Medicine, Cystic Fibrosis/Pulmonary Research and Treatment Center, Marsico Lung Institute, University of North Carolina at Chapel Hill, North Carolina 27599., Cao R; Department of Pathology and Laboratory Medicine, Cystic Fibrosis/Pulmonary Research and Treatment Center, Marsico Lung Institute, University of North Carolina at Chapel Hill, North Carolina 27599., Carpenter J; Department of Pathology and Laboratory Medicine, Cystic Fibrosis/Pulmonary Research and Treatment Center, Marsico Lung Institute, University of North Carolina at Chapel Hill, North Carolina 27599., Ford AA; Department of Pathology and Laboratory Medicine, Cystic Fibrosis/Pulmonary Research and Treatment Center, Marsico Lung Institute, University of North Carolina at Chapel Hill, North Carolina 27599., Wang T; Department of Pathology and Laboratory Medicine, Cystic Fibrosis/Pulmonary Research and Treatment Center, Marsico Lung Institute, University of North Carolina at Chapel Hill, North Carolina 27599., Li L; Department of Pathology and Laboratory Medicine, Cystic Fibrosis/Pulmonary Research and Treatment Center, Marsico Lung Institute, University of North Carolina at Chapel Hill, North Carolina 27599., Kesimer M; Department of Pathology and Laboratory Medicine, Cystic Fibrosis/Pulmonary Research and Treatment Center, Marsico Lung Institute, University of North Carolina at Chapel Hill, North Carolina 27599.

Publikováno v: Mucosal immunology [Mucosal Immunol] 2016 Nov; Vol. 9 (6), pp. 1442-1454. Date of Electronic Publication: 2016 Apr 13.