Direct interaction with the BRD4 carboxyl-terminal motif (CTM) and TopBP1 is required for human papillomavirus 16 E2 association with mitotic chromatin and plasmid segregation function.

Autor: Prabhakar AT; Virginia Commonwealth University (VCU), Philips Institute for Oral Health Research, School of Dentistry , Richmond, Virginia, USA., James CD; Virginia Commonwealth University (VCU), Philips Institute for Oral Health Research, School of Dentistry , Richmond, Virginia, USA., Fontan CT; Virginia Commonwealth University (VCU), Philips Institute for Oral Health Research, School of Dentistry , Richmond, Virginia, USA., Otoa R; Virginia Commonwealth University (VCU), Philips Institute for Oral Health Research, School of Dentistry , Richmond, Virginia, USA., Wang X; Virginia Commonwealth University (VCU), Philips Institute for Oral Health Research, School of Dentistry , Richmond, Virginia, USA., Bristol ML; Virginia Commonwealth University (VCU), Philips Institute for Oral Health Research, School of Dentistry , Richmond, Virginia, USA.; VCU Massey Cancer Center , Richmond, Virginia, USA., Yeager C; Virginia Commonwealth University (VCU), Philips Institute for Oral Health Research, School of Dentistry , Richmond, Virginia, USA., Hill RD; Virginia Commonwealth University (VCU), Philips Institute for Oral Health Research, School of Dentistry , Richmond, Virginia, USA., Dubey A; Virginia Commonwealth University (VCU), Philips Institute for Oral Health Research, School of Dentistry , Richmond, Virginia, USA., Wu S-Y; Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center , Dallas, Texas, USA.; Department of Biochemistry, University of Texas Southwestern Medical Center , Dallas, Texas, USA., Chiang C-M; Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center , Dallas, Texas, USA.; Department of Biochemistry, University of Texas Southwestern Medical Center , Dallas, Texas, USA.; Department of Pharmacology, University of Texas Southwestern Medical Center , Dallas, Texas, USA., Morgan IM; Virginia Commonwealth University (VCU), Philips Institute for Oral Health Research, School of Dentistry , Richmond, Virginia, USA.; VCU Massey Cancer Center , Richmond, Virginia, USA.

Publikováno v: Journal of virology [J Virol] 2023 Oct 31; Vol. 97 (10), pp. e0078223. Date of Electronic Publication: 2023 Sep 15.

Human Papillomavirus 16 E2 Interaction with TopBP1 Is Required for E2 and Viral Genome Stability during the Viral Life Cycle.

Autor: Prabhakar AT; Virginia Commonwealth University (VCU), Philips Institute for Oral Health Research, School of Dentistry, Richmond, Virginia, USA., James CD; Virginia Commonwealth University (VCU), Philips Institute for Oral Health Research, School of Dentistry, Richmond, Virginia, USA., Fontan CT; Virginia Commonwealth University (VCU), Philips Institute for Oral Health Research, School of Dentistry, Richmond, Virginia, USA., Otoa R; Virginia Commonwealth University (VCU), Philips Institute for Oral Health Research, School of Dentistry, Richmond, Virginia, USA., Wang X; Virginia Commonwealth University (VCU), Philips Institute for Oral Health Research, School of Dentistry, Richmond, Virginia, USA., Bristol ML; Virginia Commonwealth University (VCU), Philips Institute for Oral Health Research, School of Dentistry, Richmond, Virginia, USA.; VCU Massey Cancer Center, Richmond, Virginia, USA., Hill RD; Virginia Commonwealth University (VCU), Philips Institute for Oral Health Research, School of Dentistry, Richmond, Virginia, USA., Dubey A; Virginia Commonwealth University (VCU), Philips Institute for Oral Health Research, School of Dentistry, Richmond, Virginia, USA., Morgan IM; Virginia Commonwealth University (VCU), Philips Institute for Oral Health Research, School of Dentistry, Richmond, Virginia, USA.; VCU Massey Cancer Center, Richmond, Virginia, USA.

Publikováno v: Journal of virology [J Virol] 2023 Mar 30; Vol. 97 (3), pp. e0006323. Date of Electronic Publication: 2023 Feb 22.

Human papillomavirus 16 E2 blocks cellular senescence in response to activation of the DNA damage response.

Autor: Fontan CT; Virginia Commonwealth University (VCU), Philips Institute for Oral Health Research, School of Dentistry, Richmond, Virginia, USA., Prabhakar AT; Virginia Commonwealth University (VCU), Philips Institute for Oral Health Research, School of Dentistry, Richmond, Virginia, USA., Wang X; Virginia Commonwealth University (VCU), Philips Institute for Oral Health Research, School of Dentistry, Richmond, Virginia, USA., Karimi E; Virginia Commonwealth University (VCU), Philips Institute for Oral Health Research, School of Dentistry, Richmond, Virginia, USA., Bristol ML; Virginia Commonwealth University (VCU), Philips Institute for Oral Health Research, School of Dentistry, Richmond, Virginia, USA., James CD; Virginia Commonwealth University (VCU), Philips Institute for Oral Health Research, School of Dentistry, Richmond, Virginia, USA., Morgan IM; Virginia Commonwealth University (VCU), Philips Institute for Oral Health Research, School of Dentistry, Richmond, Virginia, USA; VCU Massey Cancer Center, Richmond, Virginia, USA. Electronic address: immorgan@vcu.edu.

Publikováno v: Virology [Virology] 2022 Oct; Vol. 575, pp. 54-62. Date of Electronic Publication: 2022 Aug 27.

Impact of the COVID-19 pandemic on otolaryngology resident rhinology education.

Autor: Murthy AK; Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA., Fontan CT; Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA., Filippa Trikantzopoulou M; Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA., Fitzpatrick TH 4th; Department of Otolaryngology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA., Levy JM; Department of Otolaryngology, Emory University School of Medicine, Atlanta, Georgia, USA., Alt JA; Department of Otolaryngology, University of Utah School of Medicine, Salt Lake City, Utah, USA., Schuman TA; Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.; Department of Otolaryngology, Virginia Commonwealth University School of Medicine, Richmond, Virginia, USA.

Publikováno v: International forum of allergy & rhinology [Int Forum Allergy Rhinol] 2022 Aug; Vol. 12 (8), pp. 1067-1070. Date of Electronic Publication: 2022 Jan 10.

CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life Cycle.

Autor: Prabhakar AT; Virginia Commonwealth Universitygrid.224260.0 (VCU), Philips Institute for Oral Health Research, School of Dentistry, Richmond, Virginia, USA., James CD; Virginia Commonwealth Universitygrid.224260.0 (VCU), Philips Institute for Oral Health Research, School of Dentistry, Richmond, Virginia, USA., Das D; Virginia Commonwealth Universitygrid.224260.0 (VCU), Philips Institute for Oral Health Research, School of Dentistry, Richmond, Virginia, USA., Otoa R; Virginia Commonwealth Universitygrid.224260.0 (VCU), Philips Institute for Oral Health Research, School of Dentistry, Richmond, Virginia, USA., Day M; Cancer Research UK DNA Repair Enzymes Group, Genome Damage and Stability Centre, School of Life Sciences, University of Sussexgrid.12082.39, Brighton, United Kingdom., Burgner J; Virginia Commonwealth Universitygrid.224260.0 (VCU), Philips Institute for Oral Health Research, School of Dentistry, Richmond, Virginia, USA., Fontan CT; Virginia Commonwealth Universitygrid.224260.0 (VCU), Philips Institute for Oral Health Research, School of Dentistry, Richmond, Virginia, USA., Wang X; Virginia Commonwealth Universitygrid.224260.0 (VCU), Philips Institute for Oral Health Research, School of Dentistry, Richmond, Virginia, USA., Glass SH; VCU School of Dentistry, Department of Oral Diagnostic Sciences, Richmond, Virginia, USA., Wieland A; Emory Vaccine Center, Emory University School of Medicine, Atlanta, Georgia, USA.; Department of Microbiology & Immunology, Emory University School of Medicine, Atlanta, Georgia, USA., Donaldson MM; School of Veterinary Medicine, University of Glasgowgrid.8756.c, Bearsden, United Kingdom., Bristol ML; Virginia Commonwealth Universitygrid.224260.0 (VCU), Philips Institute for Oral Health Research, School of Dentistry, Richmond, Virginia, USA., Li R; Virginia Commonwealth Universitygrid.224260.0 (VCU), Philips Institute for Oral Health Research, School of Dentistry, Richmond, Virginia, USA.; VCU Massey Cancer Center, Richmond, Virginia, USA., Oliver AW; Cancer Research UK DNA Repair Enzymes Group, Genome Damage and Stability Centre, School of Life Sciences, University of Sussexgrid.12082.39, Brighton, United Kingdom., Pearl LH; Cancer Research UK DNA Repair Enzymes Group, Genome Damage and Stability Centre, School of Life Sciences, University of Sussexgrid.12082.39, Brighton, United Kingdom., Smith BO; Institute of Molecular, Cell & Systems Biology, University of Glasgowgrid.8756.c, Glasgow, United Kingdom., Morgan IM; Virginia Commonwealth Universitygrid.224260.0 (VCU), Philips Institute for Oral Health Research, School of Dentistry, Richmond, Virginia, USA.; VCU Massey Cancer Center, Richmond, Virginia, USA.

Publikováno v: MBio [mBio] 2021 Oct 26; Vol. 12 (5), pp. e0116321. Date of Electronic Publication: 2021 Sep 21.