Whole-exome Sequencing Identifies SLC52A1 and ZNF106 Variants as Novel Genetic Risk Factors for (Early) Multiple-organ Failure in Acute Pancreatitis

Autor: Hjalmar C. van Santvoort, Marja A. Boermeester, Marc G. Besselink, Frank Ulrich Weiss, Frank Baas, Fons F. van den Berg, Markus M. Lerch, Yama Issa, Jeroen P. Vreijling

Publikováno v: Annals of Surgery. 275:e781-e788

Objective The aim of this study was to identify genetic variants associated with early multiple organ failure (MOF) in acute pancreatitis. Summary background data MOF is a life-threatening complication of acute pancreatitis, and risk factors are larg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b199e79d57c45e4600df89cb9dbc1a7d
https://doi.org/10.1097/sla.0000000000004312

Mesenteric Biopsy

Autor: Fons F. van den Berg, John C. Alverdy

Publikováno v: The Mesenteric Organ in Health and Disease ISBN: 9783030719623

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f3e187ba428df73f08f857e4288bef1b
https://doi.org/10.1007/978-3-030-71963-0_9

Western-type diet influences mortality from necrotising pancreatitis and demonstrates a central role for butyrate

Autor: Olga Zaborina, Sanjiv Hyoju, Marc G. Besselink, Demi van Dalen, John C. Alverdy, Fons F. van den Berg, Marja A. Boermeester, Hjalmar C. van Santvoort, Willem Joost Wiersinga

Publikováno v: Gut
Gut, 70(5):gutjnl-2019-320430, 915-927. BMJ Publishing Group

ObjectiveThe gut microbiota are the main source of infections in necrotising pancreatitis. We investigated the effect of disruption of the intestinal microbiota by a Western-type diet on mortality and bacterial dissemination in necrotising pancreatit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5397e4e91fc00b9fe339ee78bf584e3
https://pubmed.ncbi.nlm.nih.gov/32873697

Mice Fed an Obesogenic Western Diet, Administered Antibiotics, and Subjected to a Sterile Surgical Procedure Develop Lethal Septicemia with Multidrug-Resistant Pathobionts

Autor: Olga Zaborina, Wyatt Arnold, Angella Charnot-Katsikas, Peng Jianxin, Cindy Bethel, Carleen Adriaansens, Emily Papazian, Jack A. Gilbert, Neil Gottel, Robert Keskey, Sanjiv Hyoju, Alexander Zaborin, Anukriti Sharma, Sangman M. Kim, John C. Alverdy, Fons F. van den Berg

Publikováno v: mBio, Vol 10, Iss 4, p e00903-19 (2019)
mBio, Vol 10, Iss 4 (2019)
mBio, vol 10, iss 4

Despite antibiotics and sterile technique, postoperative infections remain a real and present danger to patients. Recent estimates suggest that 50% of the pathogens associated with postoperative infections have become resistant to the standard antibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfbc15e55be3ef1d532cc760cefff121
https://doaj.org/article/66d24dc6e79f499b834aff38010a30bf

Mice Fed an Obesogenic Western Diet, Administered Antibiotics, and Subjected to a Sterile Surgical Procedure Develop Lethal Septicemia with Multidrug-Resistant Pathobionts.

Autor: Hyoju SK; Department of Surgery, University of Chicago, Chicago, Illinois, USA., Zaborin A; Department of Surgery, University of Chicago, Chicago, Illinois, USA., Keskey R; Department of Surgery, University of Chicago, Chicago, Illinois, USA., Sharma A; Department of Surgery, University of Chicago, Chicago, Illinois, USA., Arnold W; Department of Surgery, University of Chicago, Chicago, Illinois, USA., van den Berg F; Department of Surgery, University of Chicago, Chicago, Illinois, USA.; Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands., Kim SM; Department of Medicine, University of Chicago, Chicago, Illinois, USA., Gottel N; Department of Surgery, University of Chicago, Chicago, Illinois, USA., Bethel C; Department of Pathology, University of Chicago, Chicago, Illinois, USA., Charnot-Katsikas A; Department of Pathology, University of Chicago, Chicago, Illinois, USA., Jianxin P; Department of Surgery, University of Chicago, Chicago, Illinois, USA.; Guangdong Province Hospital of Chinese Medicine, China., Adriaansens C; Department of Surgery, University of Chicago, Chicago, Illinois, USA.; Department of Surgery, Radboud University Medical Center, Nijmegen, The Netherlands., Papazian E; Department of Surgery, University of Chicago, Chicago, Illinois, USA., Gilbert JA; Department of Surgery, University of Chicago, Chicago, Illinois, USA., Zaborina O; Department of Surgery, University of Chicago, Chicago, Illinois, USA ozaborin@surgery.bsd.uchicago.edu jalverdy@surgery.bsd.uchicago.edu., Alverdy JC; Department of Surgery, University of Chicago, Chicago, Illinois, USA ozaborin@surgery.bsd.uchicago.edu jalverdy@surgery.bsd.uchicago.edu.

Publikováno v: MBio [mBio] 2019 Jul 30; Vol. 10 (4). Date of Electronic Publication: 2019 Jul 30.