Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Fons A van de Loo"'
Autor:
Debbie M Roeleveld, Renoud J Marijnissen, Birgitte Walgreen, Monique M Helsen, Liduine van den Bersselaar, Fons A van de Loo, Peter L van Lent, Peter M van der Kraan, Wim B van den Berg, Marije I Koenders
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171757 (2017)
Th17 cells and their cytokines are linked to the pathogenesis of rheumatoid arthritis, a chronic autoimmune disease characterized by joint inflammation. Th17 development is initiated by combined signaling of TGF-β and IL-6 or IL-21, and can be reduc
Externí odkaz:
https://doaj.org/article/78384ac380dc442c8a8468639da74800
Autor:
Louise Henningsson, Tove Eneljung, Pernilla Jirholt, Sara Tengvall, Ulf Lidberg, Wim B van den Berg, Fons A van de Loo, Inger Gjertsson
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49731 (2012)
Rheumatoid arthritis (RA) is a chronic destructive autoimmune disease characterised by periods of flare and remission. Today's treatment is based on continuous immunosuppression irrespective of the patient's inflammatory status. When the disease is i
Externí odkaz:
https://doaj.org/article/78593b0e54b94fc6a8931f498b1b8e2b
Autor:
Peter M. van der Kraan, Arjan P.M. van Caam, Esmeralda N. Blaney Davidson, Martijn H.J. van den Bosch, Fons A.J. van de Loo
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 6, Iss 2, Pp 100459- (2024)
Introduction: Articular cartilage makes smooth movement possible and destruction of this tissue leads to loss of joint function. An important biomolecule that determines this function is the large aggregating proteoglycan of cartilage, aggrecan. Aggr
Externí odkaz:
https://doaj.org/article/b72967b90e8945799f4440402ffa7eae
Autor:
Natália Valdrighi, Arjen B. Blom, Henk M. van Beuningen, Elly L. Vitters, Monique M. Helsen, Birgitte Walgreen, Peter L.E.M. van Lent, Marije I. Koenders, Peter M. van der Kraan, Fons A.J. van de Loo, Esmeralda N. Blaney Davidson
Publikováno v:
PeerJ, Vol 11, p e15482 (2023)
Background Osteoarthritis (OA) is a progressive joint disease and a major cause of chronic pain in adults. The prevalence of OA is higher in female patients, who tend to have worse OA outcomes, partially due to pain. The association between joint pai
Externí odkaz:
https://doaj.org/article/03fdaf6af3ba4d28bb9268a02e580afc
Autor:
Natália Valdrighi, Juliana P. Vago, Arjen B. Blom, Fons A.J. van de Loo, Esmeralda N. Blaney Davidson
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Osteoarthritis (OA) is a progressive whole-joint disease; no disease-modifying drugs are currently available to stop or slow its process. Symptoms alleviation is the only treatment option. OA is the major cause of chronic pain in adults, with pain be
Externí odkaz:
https://doaj.org/article/2b43ae5ca4644266b4a9397d3d698fc8
Autor:
Arjen B. Blom, Martijn H. van den Bosch, Esmeralda N. Blaney Davidson, Johannes Roth, Thomas Vogl, Fons A. van de Loo, Marije Koenders, Peter M. van der Kraan, Edwin J. Geven, Peter L. van Lent
Publikováno v:
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-15 (2020)
Abstract Background Synovitis-associated pain is mediated by inflammatory factors that may include S100A8/9, which is able to stimulate nociceptive neurons via Toll-like receptor 4. In this study, we investigated the role of S100A9 in pain response d
Externí odkaz:
https://doaj.org/article/0d3325c14e2f4f258d2c206fd533edb7
Autor:
Mathijs G.A. Broeren, Irene Di Ceglie, Miranda B. Bennink, Peter L.E.M. van Lent, Wim B. van den Berg, Marije I. Koenders, Esmeralda N. Blaney Davidson, Peter M. van der Kraan, Fons A.J. van de Loo
Publikováno v:
PeerJ, Vol 6, p e4771 (2018)
Objective Tumor necrosis factor-inducible gene 6 (TSG-6) has anti-inflammatory and chondroprotective effects in mouse models of inflammatory arthritis. Because cartilage damage and inflammation are also observed in osteoarthritis (OA), we determined
Externí odkaz:
https://doaj.org/article/e674760745904a79b44e5fdbcd6e3d74
Autor:
Elly L. Vitters, Marije I. Koenders, Joyce Aarts, Renoud M. Marijnissen, Arjan P. M. van Caam, Peter Lem van Lent, Fons Aj van de Loo, Peter M. Van Der Kraan, Monique M. Helsen, Birgitte Walgreen
ObjectivesTGF-β is an important growth factor to promote the differentiation of T helper 17 (Th17) as well as regulatory T cells (Treg). Due to its dual role, the potential of TGF-β as therapeutic target in T cell-mediated diseases like rheumatoid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a0d4173fa572836b6f179b9ffc2b4a7
https://doi.org/10.21203/rs.3.rs-840399/v1
https://doi.org/10.21203/rs.3.rs-840399/v1
Autor:
Onno J. Arntz, Miranda B. Bennink, Fons Aj van de Loo, Wim B. van den Berg, Mathijs G A Broeren
Publikováno v:
Novel technologies.
Background No disease-modifying drugs are available for osteoarthritis (OA). Although the aetiology is still unknown, inflammation is indicated to be involved in the disease pathogenesis in many patients. Gene therapy can enable transduced joint cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c085b39c1a1005b858feaddc5c9ad5f1
https://doi.org/10.1136/annrheumdis-2016-211053.7
https://doi.org/10.1136/annrheumdis-2016-211053.7
Autor:
Silke Beermann, Greg Lemke, Miranda B. Bennink, Fons Aj van de Loo, Peter Lem van Lent, Marije I. Koenders, Claire E J Waterborg, Peter M. van der Kraan, Carla V. Rothlin, Frank H J van den Hoogen
Publikováno v:
Immune regulation.
Background Rheumatoid arthritis is characterised by an inflammatory response in synovial joints, showing a predominant influx of neutrophils. These cells have a relative short life span and many of them undergo apoptosis. If they are not cleared, the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7f01d93157ac358a6e0ebe385d221c13
https://doi.org/10.1136/annrheumdis-2016-211049.6
https://doi.org/10.1136/annrheumdis-2016-211049.6