Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Fons A van de Loo"'
Autor:
Peter M. van der Kraan, Arjan P.M. van Caam, Esmeralda N. Blaney Davidson, Martijn H.J. van den Bosch, Fons A.J. van de Loo
Publikováno v:
Osteoarthritis and Cartilage Open, Vol 6, Iss 2, Pp 100459- (2024)
Introduction: Articular cartilage makes smooth movement possible and destruction of this tissue leads to loss of joint function. An important biomolecule that determines this function is the large aggregating proteoglycan of cartilage, aggrecan. Aggr
Externí odkaz:
https://doaj.org/article/b72967b90e8945799f4440402ffa7eae
Autor:
Natália Valdrighi, Arjen B. Blom, Henk M. van Beuningen, Elly L. Vitters, Monique M. Helsen, Birgitte Walgreen, Peter L.E.M. van Lent, Marije I. Koenders, Peter M. van der Kraan, Fons A.J. van de Loo, Esmeralda N. Blaney Davidson
Publikováno v:
PeerJ, Vol 11, p e15482 (2023)
Background Osteoarthritis (OA) is a progressive joint disease and a major cause of chronic pain in adults. The prevalence of OA is higher in female patients, who tend to have worse OA outcomes, partially due to pain. The association between joint pai
Externí odkaz:
https://doaj.org/article/03fdaf6af3ba4d28bb9268a02e580afc
Autor:
Joyce Aarts, Arjan van Caam, Xinlai Chen, Renoud J. Marijnissen, Monique M. Helsen, Birgitte Walgreen, Elly L. Vitters, Fons A. van de Loo, Peter L. van Lent, Peter M. van der Kraan, Marije I. Koenders
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract TGF-β1 is an important growth factor to promote the differentiation of T helper 17 (Th17) and regulatory T cells (Treg). The potential of TGF-β1 as therapeutic target in T cell-mediated diseases like rheumatoid arthritis (RA) is unclear. W
Externí odkaz:
https://doaj.org/article/e56341f6fbb745499f284ebee7d9f397
Autor:
Natália Valdrighi, Juliana P. Vago, Arjen B. Blom, Fons A.J. van de Loo, Esmeralda N. Blaney Davidson
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Osteoarthritis (OA) is a progressive whole-joint disease; no disease-modifying drugs are currently available to stop or slow its process. Symptoms alleviation is the only treatment option. OA is the major cause of chronic pain in adults, with pain be
Externí odkaz:
https://doaj.org/article/2b43ae5ca4644266b4a9397d3d698fc8
Autor:
Arjen B. Blom, Martijn H. van den Bosch, Esmeralda N. Blaney Davidson, Johannes Roth, Thomas Vogl, Fons A. van de Loo, Marije Koenders, Peter M. van der Kraan, Edwin J. Geven, Peter L. van Lent
Publikováno v:
Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-15 (2020)
Abstract Background Synovitis-associated pain is mediated by inflammatory factors that may include S100A8/9, which is able to stimulate nociceptive neurons via Toll-like receptor 4. In this study, we investigated the role of S100A9 in pain response d
Externí odkaz:
https://doaj.org/article/0d3325c14e2f4f258d2c206fd533edb7
Autor:
Mathijs G.A. Broeren, Irene Di Ceglie, Miranda B. Bennink, Peter L.E.M. van Lent, Wim B. van den Berg, Marije I. Koenders, Esmeralda N. Blaney Davidson, Peter M. van der Kraan, Fons A.J. van de Loo
Publikováno v:
PeerJ, Vol 6, p e4771 (2018)
Objective Tumor necrosis factor-inducible gene 6 (TSG-6) has anti-inflammatory and chondroprotective effects in mouse models of inflammatory arthritis. Because cartilage damage and inflammation are also observed in osteoarthritis (OA), we determined
Externí odkaz:
https://doaj.org/article/e674760745904a79b44e5fdbcd6e3d74
Autor:
Debbie M Roeleveld, Renoud J Marijnissen, Birgitte Walgreen, Monique M Helsen, Liduine van den Bersselaar, Fons A van de Loo, Peter L van Lent, Peter M van der Kraan, Wim B van den Berg, Marije I Koenders
Publikováno v:
PLoS ONE, Vol 12, Iss 2, p e0171757 (2017)
Th17 cells and their cytokines are linked to the pathogenesis of rheumatoid arthritis, a chronic autoimmune disease characterized by joint inflammation. Th17 development is initiated by combined signaling of TGF-β and IL-6 or IL-21, and can be reduc
Externí odkaz:
https://doaj.org/article/78384ac380dc442c8a8468639da74800
Autor:
Elly L. Vitters, Marije I. Koenders, Joyce Aarts, Renoud M. Marijnissen, Arjan P. M. van Caam, Peter Lem van Lent, Fons Aj van de Loo, Peter M. Van Der Kraan, Monique M. Helsen, Birgitte Walgreen
ObjectivesTGF-β is an important growth factor to promote the differentiation of T helper 17 (Th17) as well as regulatory T cells (Treg). Due to its dual role, the potential of TGF-β as therapeutic target in T cell-mediated diseases like rheumatoid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a0d4173fa572836b6f179b9ffc2b4a7
https://doi.org/10.21203/rs.3.rs-840399/v1
https://doi.org/10.21203/rs.3.rs-840399/v1
Autor:
Eline A. Vermeij, Marije I. Koenders, Arjen B. Blom, Onno J. Arntz, Miranda B. Bennink, Wim B. van den Berg, Peter L.E.M. van Lent, Fons A.J. van de Loo
Publikováno v:
Molecular Imaging, Vol 13 (2014)
Rheumatoid arthritis (RA) and osteoarthritis (OA) are serologically and clinically distinctive, but at the local level, both diseases have many molecular pathways in common. In vivo molecular imaging can unravel the local pathologic processes involve
Externí odkaz:
https://doaj.org/article/28070d24be67493c9d7e39c91239ac85
Autor:
Louise Henningsson, Tove Eneljung, Pernilla Jirholt, Sara Tengvall, Ulf Lidberg, Wim B van den Berg, Fons A van de Loo, Inger Gjertsson
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e49731 (2012)
Rheumatoid arthritis (RA) is a chronic destructive autoimmune disease characterised by periods of flare and remission. Today's treatment is based on continuous immunosuppression irrespective of the patient's inflammatory status. When the disease is i
Externí odkaz:
https://doaj.org/article/78593b0e54b94fc6a8931f498b1b8e2b