Výsledky vyhledávání - "Fong, Clifford"

Akademický článek

Platinum based radiochemotherapies: Free radical mechanisms and radiotherapy sensitizers

Autor: Fong, Clifford W.

Publikováno v: In Free Radical Biology and Medicine October 2016 99:99-109

Akademický článek

Binding energies of tyrosine kinase inhibitors: Error assessment of computational methods for imatinib and nilotinib binding

Autor: Fong, Clifford W.

Publikováno v: In Computational Biology and Chemistry October 2015 58:40-54

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Akademický článek

Statins in therapy: Understanding their hydrophilicity, lipophilicity, binding to 3-hydroxy-3-methylglutaryl-CoA reductase, ability to cross the blood brain barrier and metabolic stability based on electrostatic molecular orbital studies

Autor: Fong, Clifford W.

Publikováno v: In European Journal of Medicinal Chemistry 6 October 2014 85:661-674

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Efficacy of some repurposed anti-Covid-19 nucleotide analogs against RNA-dependent RNA polymerase: molecular electrostatic mechanisms using quantum mechanics

Autor: Fong, Clifford

A study of some commonly used anti-viral nucleotide analogs using quantum mechanical methods has been carried out. Specifically the binding of nucleoside triphosphates (NTPs derived from IDX-184, Ribavirin, Sofosbuvir, Remdesivir, Molnupiravir, Favip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od_______166::07534ff538828ab46dd330909e573810
https://hal.archives-ouvertes.fr/hal-03680703

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COVID-19: predicting inhibition of the main protease and therapeutic intracellular accumulation and plasma and lung concentrations of repurposed inhibitors

Autor: Fong, Clifford

Publikováno v: [Research Report] Eigenenergy. 2020

It has been shown that a linear free energy relationship (LFER) can describe the structure activity of the inhibition of the main protease M pro of COVID-19 or SARS-Cov-2. Application of this LFER can be used to predictably rank the inhibitory effica

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::774bbc6f07c43ccbcd2cf1974fe1cc07
https://hal.archives-ouvertes.fr/hal-02917312/document

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Screening potential repurposed COVID-2019 3C-like protease inhibitors

Autor: Fong, Clifford, Australia, South

Publikováno v: [Research Report] Eigenenergy. 2020

This study describes a linear free energy quantum mechanical method for relatively ranking how well a wide range of repurposed drugs might inhibit the SARS-CoV-2 protease. Inhibitors that are predominantly charged at physiological pH, such as Hydroxy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::c7b247f9dc1d375ed9b95fe8f4d02fff
https://hal.archives-ouvertes.fr/hal-02663287/document

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Screening potential anti-virals for the main protease of the Coronaviridae family including SARS-CoV-2, SARS-CoV, MERS

Autor: Fong, Clifford

Publikováno v: [Research Report] Eigenenergy South Australia. 2020

It has been shown that structural activity of series of inhibitors based on a linear free energyrelationship involving the water desolvation, lipophilicity, dipole moment and the HOMOLUMO,LUMO or HOMO applies to the bat HKU4 3CLpro and SARS-CoV 3CLpr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::22ebc538f16e565cd2c1cefddbaf402e
https://hal.archives-ouvertes.fr/hal-02897882

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Inhibition of SARS-CoV-2 envelope ion channel and the relationship with the membrane dipole potential

Autor: Fong, Clifford

Publikováno v: [Research Report] Eigenenergy Adelaide South Australia Australia. 2021

This study has identified a predictive quantum mechanical TD DFT method which can describe the time dependent behaviour of inhibitors of voltage gated ion channels. The key determinants are the excitation energy of the first excited state of the inhi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::31f8f929b798d00649efc84467e9ce9d
https://hal.archives-ouvertes.fr/hal-03200926/document

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Anti-tuberculosis drugs: targeting outer membrane channel proteins, ion channel blockers and the use of cucurbit[7]uril as an excipient to improve oral drug delivery and efficacy against resistant Mycobacterium Tuberculosis

Autor: Fong, Clifford

Publikováno v: [Research Report] Eigenenergy Adelaide, South Australia, Australia. 2021

This study shows that the antibiotic resistance of 14 drugs is primarily dependent upon the lipophilicity ofthe drugs for wt M. bovis BCG and the mutants cpnT::Tn/mspA and cpnT::Tn/cpnT. The outer membranechannel protein CpnT of M. tuberculosis is es

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::6c7e960cacadee2d987b2053757f41af
https://hal.archives-ouvertes.fr/hal-03265354/document

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Ionophores and inhibition of SARS-CoV-2 ion channels

Autor: Fong, Clifford

Publikováno v: [Research Report] Eigenenergy Adelaide, South Australia, Australia. 2021

This study uses a previously described predictive quantum mechanical TD DFT method which can describe the time dependent behaviour of inhibitors of voltage controlled ion channels. The method is shown to apply to a widely diverse range of polyether a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::203ac316f56025d45b974916349e2b70
https://hal.archives-ouvertes.fr/hal-03347139

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