Delayed treatment with hydro-ethanolic extract of Khaya grandifoliola protects mice from acetaminophen-hepatotoxicity through inhibition of c-Jun N-terminal kinase phosphorylation and mitochondrial dysfunction

Autor: Arnaud Fondjo Kouam, Ibrahim Njingou, Nina Jeannette Pekam Magoudjou, Hamed Bechir Ngoumbe, Philipe Herman Nfombouot Njitoyap, Elisabeth Menkem Zeuko'o, Frédéric Nico Njayou, Paul Fewou Moundipa

Publikováno v: Pharmaceutical Science Advances, Vol 2, Iss , Pp 100049- (2024)

The use of N-acetylcysteine against acetaminophen(APAP)-induced hepatotoxicity, a leading cause of liver injury, has several drawbacks, including short therapeutic windows. Khaya grandifoliola (Meliaceae) has been traditionally used to manage liver-r

Externí odkaz: https://doaj.org/article/b915f3f078fa41c1bd3edb7010143668

Comparative assessment of hepatoprotective properties of Artesunate and flavonoids from Artemisia annua on acetaminophen and carbon tetrachloride-induced cytotoxicity in primary mice hepatocytes

Autor: Marie Ange Djeungoue Petga, Arnaud Fondjo Kouam, Rosine Désirée Chougouo Kengne, Boris Rosnay Galani Tietcheu, Josué Simo Louokdom, Claude Bérenger Ngantchouko Ngalemo, Pascal Dieudonné Chuisseu Djamen, Paul Fewou Moundipa

Publikováno v: Metabolism Open, Vol 18, Iss , Pp 100241- (2023)

Background: Artesunate (ART) is a semi-synthetized molecule from Artemisinin, an active compound isolated from the medicinal plant Artemisia annua, widely used for the treatment of malaria. Previous studies reported that ART may exert a dual effect o

Externí odkaz: https://doaj.org/article/64e93787a7d94cfba97db4e7ea91d904

Inhibition of CYP2E1 and activation of Nrf2 signaling pathways by a fraction from Entada africana alleviate carbon tetrachloride-induced hepatotoxicity

Autor: Arnaud Fondjo Kouam, Brice Ayissi Owona, Rodrigue Fifen, Frédéric Nico Njayou, Paul Fewou Moundipa

Publikováno v: Heliyon, Vol 6, Iss 8, Pp e04602- (2020)

Entada africana is used in non-conventional medicine for the management of liver ailments. A fraction, designated EaF10 (methylene chloride/methanol 90:10, v/v) with promising hepatoprotective activity has been isolated. Since the mechanisms underlyi

Externí odkaz: https://doaj.org/article/907963e2467b407aa1ef935bae5cc129

Aqueous extracts of Desmodium adscendens (Fabaceae) possess in vitro antioxidant properties and protect hepatocytes from Carbone tetrachloride-induced injury and Hepatitis C Virus infection

Autor: Gisa Tiegs, Angèle N. Tchana, Karin Seron, Arnaud Fondjo Kouam, Paul F. Moundipa, Brice Fredy Nemg Simo, Pascal Dieudonne Djamen Chuisseu, Jonas Kouamouo, Jean Dubuisson, Nelly C.K. Younang, Boris R.G. Tietcheu

Publikováno v: Investigational Medicinal Chemistry and Pharmacology. 3:1-10

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::592bbc3d311a62f61e78322b2105d9fc
https://doi.org/10.31183/imcp.2020.00036

In silico and in vitro screening of licensed antimalarial drugs for repurposing as inhibitors of hepatitis E virus

Autor: Laurence Cocquerel, Pascal Dieudonne Djamen Chuisseu, Vincent Brice Ayissi Owona, Cécile-Marie Aliouat-Denis, Karoline Metzger, Romeo Joel Guemmogne Temdie, Marie A. Amougou, Borris Rosnay Tietcheu Galani, Marceline Ngounoue Djuidje, Arnaud Fondjo Kouam, Paul F. Moundipa

Publikováno v: In Silico Pharmacology
In Silico Pharmacology, 2021, 9 (1), pp.35. ⟨10.1007/s40203-021-00093-y⟩
In Silico Pharmacology, Springer, 2021, 9 (1), pp.35. ⟨10.1007/s40203-021-00093-y⟩

Hepatitis E virus (HEV) infection is emerging in Cameroon and represents one of the most common causes of acute hepatitis and jaundice. Moreover, earlier reports showed evidence of falciparum malaria/HEVcoexistence. Although the Sofosbuvir/Ribavirin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22acb14d46f58bd23d386bafbfd6a0de
https://doi.org/10.1007/s40203-021-00093-y