Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Fomovska, A."'
Autor:
Alina M. Fomovska, Eric Isaacs
Publikováno v:
Palliative Care in Emergency Medicine ISBN: 0190073829
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7493c7f0b8fc76e59a1aebb47afe960f
https://doi.org/10.1093/med/9780190073824.003.0004
https://doi.org/10.1093/med/9780190073824.003.0004
Autor:
Lai, Bo-Shiun, Witola, William H., El Bissati, Kamal, Zhou, Ying, Mui, Ernest, Fomovska, Alina, McLeod, Rima
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America, 2012 Aug . 109(35), 14182-14187.
Externí odkaz:
https://www.jstor.org/stable/41701663
Autor:
Fomovska, Alina, Capobianco, Sara
Publikováno v:
In Journal of Pain and Symptom Management May 2022 63(5):861-862
Publikováno v:
Antimicrobial Agents and Chemotherapy. 58:1789-1792
Here, we show that spiroindolone, an effective treatment for plasmodia, is also active against Toxoplasma gondii tachyzoites. In vitro , spiroindolone NITD609 is cidal for tachyzoites (50% inhibitory concentration [IC 50 ], 1μM) and not toxic to hum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfc2325973935afad41cffd1f4552401
https://doi.org/10.1128/aac.02225-13
https://doi.org/10.1128/aac.02225-13
Autor:
Gustavo A. Afanador, Kamal El Bissati, Rima McLeod, Patty J. Lee, Sean T. Prigge, Alan P. Kozikowski, Jozef Stec, Stuart Woods, Jennifer M. Auschwitz, Ying Zhou, Mark Hickman, Susan E. Leed, Stephen P. Muench, Craig W. Roberts, Bo Shiun Lai, David W. Rice, Alina Fomovska, Caroline Sommervile
Publikováno v:
ChemMedChem. 8:1138-1160
Through our focused effort to discover new and effective agents against toxoplasmosis, a structure-based drug design approach was used to develop a series of potent inhibitors of the enoyl-acyl carrier protein (ACP) reductase (ENR) enzyme in Toxoplas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bed39988fc78dba60012565483b42e2
https://doi.org/10.1002/cmdc.201300050
https://doi.org/10.1002/cmdc.201300050
Autor:
Jitenter P. Dubey, Caroline Sommerville, Craig W. Roberts, Mark Hickman, Ernest Mui, Leandra R. Ferreira, Jennifer M. Auschwitz, William J. Welsh, Rima McLeod, Richard D. Wood, Alina Fomovska, Stuart Woods, Patricia J. Lee, Susan E. Leed
Publikováno v:
Journal of Medicinal Chemistry. 55:8375-8391
Toxoplasma gondii(T. gondii) is an apicomplexan parasite that can cause eye disease, brain disease, and death, especially in congenitally infected and immune-compromised people. Novel medicines effective against both active and latent forms of the pa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7363c66db28388421bf9b1d7fce2ccf0
https://doi.org/10.1021/jm3007596
https://doi.org/10.1021/jm3007596
Autor:
Afanador, G.A., Muench, S.P., McPhillie, M., Fomovska, A., Schoen, A., Zhou, Y., Cheng, G., Stec, J., Freundlich, J.S., Shieh, H-M., Anderson, J.W., Jacobus, D.P., Fidock, D.A., Kozikowski, A.P., Fishwick, C.W., Rice, D.W., Freire, E., McLeod, R., Prigge, S.T.
Many microbial pathogens rely on a type II fatty acid synthesis (FASII) pathway that is distinct from the type I pathway found in humans. Enoyl-acyl carrier protein reductase (ENR) is an essential FASII pathway enzyme and the target of a number of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=core_ac_uk__::f4b07d9de578ff8a3b4003d9940642c7
https://eprints.whiterose.ac.uk/110828/1/nihms549163.pdf
https://eprints.whiterose.ac.uk/110828/1/nihms549163.pdf
Autor:
Colin W. G. Fishwick, Arne Schön, David P. Jacobus, Gustavo A. Afanador, Rima McLeod, Jozef Stec, David A. Fidock, Ernesto Freire, Gang Cheng, Sean T. Prigge, Joel S. Freundlich, John W. Anderson, Alan P. Kozikowski, David W. Rice, Hong Ming Shieh, Alina Fomovska, Stephen P. Muench, Ying Zhou, Martin J. McPhillie
Publikováno v:
Biochemistry. 52(51)
Many microbial pathogens rely on a type II fatty acid synthesis (FASII) pathway that is distinct from the type I pathway found in humans. Enoyl-acyl carrier protein reductase (ENR) is an essential FASII pathway enzyme and the target of a number of an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5e9e643b050bdaa5883e218e8e79d55
https://pubmed.ncbi.nlm.nih.gov/24295325
https://pubmed.ncbi.nlm.nih.gov/24295325
Autor:
Cheng, Gang, Muench, Stephen P., Zhou, Ying, Afanador, Gustavo A., Mui, Ernest J., Fomovska, Alina, Lai, Bo Shiun, Prigge, Sean T., Woods, Stuart, Roberts, Craig W., Hickman, Mark R., Lee, Patty J., Leed, Susan E., Auschwitz, Jennifer M., Rice, David W., McLeod, Rima
Publikováno v:
In Bioorganic & Medicinal Chemistry Letters 1 April 2013 23(7):2035-2043
Autor:
Alina Fomovska, Patty J. Lee, Craig W. Roberts, Ying Zhou, Stephen P. Muench, Gustavo A. Afanador, Ernest Mui, Bo Shiun Lai, Gang Cheng, Rima McLeod, Jennifer M. Auschwitz, Stuart Woods, Susan E. Leed, David W. Rice, Mark Hickman, Sean T. Prigge
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(7)
Triclosan is a potent inhibitor of Toxoplasma gondii enoyl reductase (TgENR), which is an essential enzyme for parasite survival. In view of triclosan's poor druggability, which limits its therapeutic use, a new set of B-ring modified analogs were de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efaeb684dc6cb3cf547f789afd23481e
https://pubmed.ncbi.nlm.nih.gov/23453069
https://pubmed.ncbi.nlm.nih.gov/23453069