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Systematic discovery and validation of T cell targets directed against oncogenic KRAS mutations.

Autor: Choi J; BioNTech US Inc., 40 Erie Street, Suite 110, Cambridge, MA 02139, USA., Goulding SP; BioNTech US Inc., 40 Erie Street, Suite 110, Cambridge, MA 02139, USA., Conn BP; BioNTech US Inc., 40 Erie Street, Suite 110, Cambridge, MA 02139, USA., McGann CD; BioNTech US Inc., 40 Erie Street, Suite 110, Cambridge, MA 02139, USA., Dietze JL; BioNTech US Inc., 40 Erie Street, Suite 110, Cambridge, MA 02139, USA., Kohler J; BioNTech US Inc., 40 Erie Street, Suite 110, Cambridge, MA 02139, USA., Lenkala D; BioNTech US Inc., 40 Erie Street, Suite 110, Cambridge, MA 02139, USA., Boudot A; BioNTech US Inc., 40 Erie Street, Suite 110, Cambridge, MA 02139, USA., Rothenberg DA; BioNTech US Inc., 40 Erie Street, Suite 110, Cambridge, MA 02139, USA., Turcott PJ; BioNTech US Inc., 40 Erie Street, Suite 110, Cambridge, MA 02139, USA., Srouji JR; BioNTech US Inc., 40 Erie Street, Suite 110, Cambridge, MA 02139, USA., Foley KC; BioNTech US Inc., 40 Erie Street, Suite 110, Cambridge, MA 02139, USA., Rooney MS; BioNTech US Inc., 40 Erie Street, Suite 110, Cambridge, MA 02139, USA., van Buuren MM; BioNTech US Inc., 40 Erie Street, Suite 110, Cambridge, MA 02139, USA., Gaynor RB; BioNTech US Inc., 40 Erie Street, Suite 110, Cambridge, MA 02139, USA., Abelin JG; BioNTech US Inc., 40 Erie Street, Suite 110, Cambridge, MA 02139, USA., Addona TA; BioNTech US Inc., 40 Erie Street, Suite 110, Cambridge, MA 02139, USA., Juneja VR; BioNTech US Inc., 40 Erie Street, Suite 110, Cambridge, MA 02139, USA.

Publikováno v: Cell reports methods [Cell Rep Methods] 2021 Sep 16; Vol. 1 (5), pp. 100084. Date of Electronic Publication: 2021 Sep 16 (Print Publication: 2021).

T cell receptor cross-reactivity expanded by dramatic peptide-MHC adaptability.

Autor: Riley TP; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA.; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA., Hellman LM; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA.; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA., Gee MH; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA., Mendoza JL; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA., Alonso JA; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA., Foley KC; Department of Surgery, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL, USA., Nishimura MI; Department of Surgery, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, IL, USA., Vander Kooi CW; Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA., Garcia KC; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA, USA.; Department of Structural Biology, Stanford University School of Medicine, Stanford, CA, USA., Baker BM; Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA. brian-baker@nd.edu.; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA. brian-baker@nd.edu.

Publikováno v: Nature chemical biology [Nat Chem Biol] 2018 Oct; Vol. 14 (10), pp. 934-942. Date of Electronic Publication: 2018 Sep 17.

TCR modifications that enhance chain pairing in gene-modified T cells can augment cross-reactivity and alleviate CD8 dependence.

Autor: Spear TT; Department of Surgery, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, Illinois, USA., Foley KC; Department of Surgery, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, Illinois, USA., Garrett-Mayer E; Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.; Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina, USA., Nishimura MI; Department of Surgery, Cardinal Bernardin Cancer Center, Loyola University Chicago, Maywood, Illinois, USA.

Publikováno v: Journal of leukocyte biology [J Leukoc Biol] 2018 May; Vol. 103 (5), pp. 973-983. Date of Electronic Publication: 2018 Jan 19.

Critical biological parameters modulate affinity as a determinant of function in T-cell receptor gene-modified T-cells.

Autor: Spear TT; Department of Surgery, Cardinal Bernardin Cancer Center, Loyola University Chicago, 2160 S. 1st Ave, Bldg 112, Room 308, Maywood, IL, 60153, USA. tspear@luc.edu., Wang Y; Department of Chemistry and Biochemistry and the Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, 46556, USA., Foley KC; Department of Surgery, Cardinal Bernardin Cancer Center, Loyola University Chicago, 2160 S. 1st Ave, Bldg 112, Room 308, Maywood, IL, 60153, USA., Murray DC; Department of Surgery, Cardinal Bernardin Cancer Center, Loyola University Chicago, 2160 S. 1st Ave, Bldg 112, Room 308, Maywood, IL, 60153, USA., Scurti GM; Department of Surgery, Cardinal Bernardin Cancer Center, Loyola University Chicago, 2160 S. 1st Ave, Bldg 112, Room 308, Maywood, IL, 60153, USA., Simms PE; Flow Cytometry Core Facility, Office of Research Services, Loyola University Chicago, Maywood, IL, 60153, USA., Garrett-Mayer E; Department of Public Health Sciences, Medical University of South Carolina, Charleston, SC, 29415, USA.; Hollings Cancer Center, Medical University of South Carolina, Charleston, SC, 29415, USA., Hellman LM; Department of Chemistry and Biochemistry and the Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, 46556, USA., Baker BM; Department of Chemistry and Biochemistry and the Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, 46556, USA., Nishimura MI; Department of Surgery, Cardinal Bernardin Cancer Center, Loyola University Chicago, 2160 S. 1st Ave, Bldg 112, Room 308, Maywood, IL, 60153, USA.

Publikováno v: Cancer immunology, immunotherapy : CII [Cancer Immunol Immunother] 2017 Nov; Vol. 66 (11), pp. 1411-1424. Date of Electronic Publication: 2017 Jun 20.