Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Folami L, Powell"'
Autor:
Ravirajsinh N. Jadeja, Malita A. Jones, Ammar A. Abdelrahman, Folami L. Powell, Menaka C. Thounaojam, Diana Gutsaeva, Manuela Bartoli, Pamela M. Martin
Publikováno v:
Redox Biology, Vol 28, Iss , Pp - (2020)
The retinal pigment epithelium (RPE) is consistently exposed to high levels of pro-oxidant and inflammatory stimuli. As such, under normal conditions the antioxidant machinery in the RPE cell is one of the most efficient in the entire body. However,
Externí odkaz:
https://doaj.org/article/ec994286402a463f82b458cbbb257d5d
Autor:
Hossameldin Abouhish, Menaka C. Thounaojam, Ravirajsinh N. Jadeja, Diana R. Gutsaeva, Folami L. Powell, Mohamed Khriza, Pamela M. Martin, Manuela Bartoli
Publikováno v:
Antioxidants, Vol 9, Iss 7, p 599 (2020)
We investigated the contributing role of the histone deacetylase 6 (HDAC6) to the early stages of diabetic retinopathy (DR). Furthermore, we examined the mechanism of action of HDAC6 in human retinal endothelial cells (HuREC) exposed to glucidic stre
Externí odkaz:
https://doaj.org/article/196a88b993884b209ec1fd93381e9838
Autor:
Diana R Gutsaeva, Lamiaa Shalaby, Folami L Powell, Menaka C Thounaojam, Hossameldin Abouhish, Sara A Wetzstein, Ravirajsinh N Jadeja, Hang Fai Kwok, Pamela M Martin, Manuela Bartoli
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 15, p 5379 (2020)
Retinal ischemia contributes to visual impairment in ischemic retinopathies. A disintegrin and metalloproteinase ADAM17 is implicated in multiple vascular pathologies through its ability to regulate inflammatory signaling via ectodomain shedding. We
Externí odkaz:
https://doaj.org/article/e1d82901d9e841e4af76c451ba92a190
Autor:
Menaka C. Thounaojam, Ravirajsinh N. Jadeja, Marie Warren, Folami L. Powell, Raghavan Raju, Diana Gutsaeva, Sandeep Khurana, Pamela M. Martin, Manuela Bartoli
Publikováno v:
Antioxidants, Vol 8, Iss 9, p 328 (2019)
Stress-associated premature senescence (SAPS) is involved in retinal microvascular injury and diabetic retinopathy. We have investigated the role and mode of action of miR-34a in retinal endothelial cells senescence in response to glucidic stress. Hu
Externí odkaz:
https://doaj.org/article/1d522235784e494a93efbbcf08251c81
Autor:
Donghyun Jee, Diana Gutsaeva, Wan Jin Jahng, Faith Pwaniyibo Samson, Kook Lee, Srinivas R. Sripathi, Manuela Bartoli, Weilue He, Joshua Osuigwe Madu, Folami L. Powell, Ambrose Teru Patrick, Seulggie Choi
Publikováno v:
J Diabetes Metab Disord
PURPOSE: The current study aims to determine the molecular mechanisms of diabetic retinopathy (DR) using the protein-protein interactome and metabolome map. We examined the protein network of novel biomarkers of DR for direct (physical) and indirect
Autor:
Ammar A. Abdelrahman, Folami L. Powell, Ravirajsinh N. Jadeja, Malita A. Jones, Menaka C. Thounaojam, Manuela Bartoli, Mohamed Al-Shabrawey, Pamela M. Martin
Publikováno v:
Experimental Eye Research. 221:109129
Preservation of retinal barrier function is critical to maintenance of retinal health. Therefore, it is not surprising that loss of barrier integrity is a pathologic feature common to degenerative retinal diseases such as diabetic retinopathy. Our pr
Autor:
Malita A, Jones, Ravirajsinh N, Jadeja, Orneika, Flandrin, Ammar A, Abdelrahman, Menaka C, Thounojam, Shakera, Thomas, Caihong, Dai, Haiyan, Xiao, Jian-Kang, Chen, Sylvia B, Smith, Manuela, Bartoli, Pamela M, Martin, Folami L, Powell
Publikováno v:
Neuropeptides. 94:102258
Diabetic retinopathy (DR) is a neurodegenerative disease that results as a complication of dysregulated glucose metabolism, or diabetes. The signaling of insulin is lost or dampened in diabetes, but this hormone has also been shown to be an important
Autor:
Folami L. Powell, Diana Gutsaeva, Manuela Bartoli, Annalisa Montemari, Francesco Facchiano, Amany Tawfik, Guido Ripandelli, Andrea Repossi, Menaka Thounaojam, Prerana Malla, Alessandra Bachettoni, Pamela M. Martin
Publikováno v:
Diabetes
We have investigated the contributing role of monosodium urate (MSU) to the pathological processes associated with the induction of diabetic retinopathy (DR). In human postmortem retinas and vitreous from donors with DR, we have found a significant i
Autor:
Pamela M. Martin, Ollya Fromal, Manuela Bartoli, Amany Tawfik, Jahng Wj, Pachiappan Arjunan, Nagendra Singh, Malita A Jones, Chopra Dg, Mohamed Al-Shabrawey, Ravirajsinh N. Jadeja, Matthew Kaufman, Alan Saul, Folami L. Powell
BackgroundExcessive oxidative stress and related chronic, sub-clinical inflammation is linked causally to the development and progression of degenerative diseases of the retina including diabetic retinopathy, age-related macular degeneration and glau
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81d954cc5dc55cc3a55d34d24c936d2d
https://doi.org/10.1101/2021.03.15.435493
https://doi.org/10.1101/2021.03.15.435493
Autor:
Diana Gutsaeva, Hossameldin Abouhish, Manuela Bartoli, Menaka Thounaojam, Mohamed Mhmoud Khriza, Folami L. Powell, Ravirajsinh N. Jadeja, Pamela M. Martin
Publikováno v:
Antioxidants
Volume 9
Issue 7
Antioxidants, Vol 9, Iss 599, p 599 (2020)
Volume 9
Issue 7
Antioxidants, Vol 9, Iss 599, p 599 (2020)
We investigated the contributing role of the histone deacetylase 6 (HDAC6) to the early stages of diabetic retinopathy (DR). Furthermore, we examined the mechanism of action of HDAC6 in human retinal endothelial cells (HuREC) exposed to glucidic stre