Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Folake Orafidiya"'
Publikováno v:
Cancer Research. 83:2635-2635
Introduction: There is a need for ADC payloads with an improved therapeutic index, consequently we have coupled potent and selective inhibitors of NMT to trastuzumab to test their potential in both in vitro and in vivo models. Experimental Procedures
Autor:
Anabel Varela-Carver, Ines Figueiredo, Yang Liu, Folake Orafidiya, Ian G. Mills, Joanna Hester, Bono Johann de, Oliwia Cyran, Richard J. Bryant, Charlotte L. Bevan, Wei Yuan, Karen E. Knudsen, Hiromi Kudo, Shuang G Zhao, Robert G. Bristow, Lin Deng, Antje Neeb, Eileen Parkes, Bora Gurel, Felix Y. Feng, Yiannis Philippou, Theodora Constantin, Fadi Issa, Denisa Bogdan, Marc Lorentzen, Ronnie Rodrigues Pereira, Simon H. Reed, Felix Dobbs, Claire E. Fletcher
Publikováno v:
Endocrine Abstracts.
Publikováno v:
Cancers, Vol 14, Iss 755, p 755 (2022)
It is increasingly appreciated that transcripts derived from non-coding parts of the human genome, such as long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), are key regulators of biological processes both in normal physiology and disease. Their
Autor:
Folake Orafidiya, Simon H. Reed, Wei Yuan, Claire E. Fletcher, Yiannis Philippou, Emma A Murphy, Lin Deng, Ian G. Mills, Fadi Issa, Richard J. Bryant, Felix Dobbs, Shuang G. Zhao, Joanna Hester, Karen E. Knudsen, Antje Neeb, Ines Figueiredo, Damien A. Leach, Charlotte L. Bevan, Bora Gurel, Johann S. de Bono, Denisa Bogdan
Publikováno v:
Cancer Research. 81:2362-2362
NORAD (NOn-Coding RNA Activated by DNA Damage) is a highly-abundant, evolutionarily-conserved lncRNA. It maintains mitosis, DNA damage repair (DDR), and chromosomal integrity through PUM1/2 sequestration (PUM1/2 activity increases turnover of DDR fac