Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Focus: 50 Years of DNA Repair: The Yale Symposium Reports"'
Autor:
Wood, Richard D.
Publikováno v:
The Yale Journal of Biology and Medicine
This short article summarizes some of the research carried out recently by my laboratory colleagues on the function of DNA polymerase zeta (polζ) in mammalian cells. Some personal background is also described, relevant to research associations with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::dc0e6b574abcf81cfa4f0728ac85dc43
http://europepmc.org/articles/PMC3848105
http://europepmc.org/articles/PMC3848105
Autor:
Jensen, Ryan B.
Publikováno v:
The Yale Journal of Biology and Medicine
DNA damage, malfunctions in DNA repair, and genomic instability are processes that intersect at the crossroads of carcinogenesis. Underscoring the importance of DNA repair in breast and ovarian tumorigenesis is the familial inherited cancer predispos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::54631026c216a8b1dd4bc3830debe6ee
http://europepmc.org/articles/PMC3848102
http://europepmc.org/articles/PMC3848102
Publikováno v:
The Yale Journal of Biology and Medicine
Hypoxia is a characteristic feature of solid tumors and occurs very early in neoplastic development. Hypoxia transforms cell physiology in multiple ways, with profound changes in cell metabolism, cell growth, susceptibility to apoptosis, induction of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::07a15c618f70a723772e0dec1bd5df72
http://europepmc.org/articles/PMC3848098
http://europepmc.org/articles/PMC3848098
Publikováno v:
The Yale Journal of Biology and Medicine
Since its discovery and purification in 1971, DNA polymerase ß (Pol ß) is one of the most well-studied DNA polymerases. Pol ß is a key enzyme in the base excision repair (BER) pathway that functions in gap filling DNA synthesis subsequent to the e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d521d0bd10e5653b116199851d05a2c7
https://pubmed.ncbi.nlm.nih.gov/24348210
https://pubmed.ncbi.nlm.nih.gov/24348210
Autor:
W Dean, Rupp
Publikováno v:
The Yale Journal of Biology and Medicine
The discovery of nucleotide excision repair in 1964 showed that DNA could be repaired by a mechanism that removed the damaged section of a strand and replaced it accurately by using the remaining intact strand as the template. This result showed that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0fa4602d96eeae1babdf621f2e79432d
https://pubmed.ncbi.nlm.nih.gov/24348214
https://pubmed.ncbi.nlm.nih.gov/24348214
Autor:
Gary M, Kupfer
Publikováno v:
The Yale Journal of Biology and Medicine
Fanconi anemia (FA) is a fascinating, rare genetic disorder marked by congenital defects, bone marrow failure, and cancer susceptibility. Research in recent years has led to the elucidation of FA as a DNA repair disorder and involved multiple pathway
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a932c8d852ed66e9178cb23b7fa76758
https://pubmed.ncbi.nlm.nih.gov/24348213
https://pubmed.ncbi.nlm.nih.gov/24348213
Publikováno v:
The Yale Journal of Biology and Medicine
The DNA double-strand break (DSB), arising from exposure to ionizing radiation or various chemotherapeutic agents or from replication fork collapse, is among the most dangerous of chromosomal lesions. DSBs are highly cytotoxic and can lead to translo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::213b75af6a425017dea3b2dc8f326523
https://pubmed.ncbi.nlm.nih.gov/24348209
https://pubmed.ncbi.nlm.nih.gov/24348209
Autor:
Faye A, Rogers, Meetu Kaushik, Tiwari
Publikováno v:
The Yale Journal of Biology and Medicine
Cellular DNA damage response is critical to preserving genomic integrity following exposure to genotoxic stress. A complex series of networks and signaling pathways become activated after DNA damage and trigger the appropriate cellular response, incl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b462c149598807af9868e1411f6e2fe9
https://pubmed.ncbi.nlm.nih.gov/24348211
https://pubmed.ncbi.nlm.nih.gov/24348211
Autor:
Philip C, Hanawalt
Publikováno v:
The Yale Journal of Biology and Medicine
As a graduate student with Professor Richard Setlow at Yale in the late 1950s, I studied the effects of ultraviolet and visible light on the syntheses of DNA, RNA, and protein in bacteria. I reflect upon my research in the Yale Biophysics Department,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::258a73687762f1197bb06a3bd0d733fd
https://pubmed.ncbi.nlm.nih.gov/24348216
https://pubmed.ncbi.nlm.nih.gov/24348216
Autor:
Sweasy, Joann B., Glazer, Peter M.
Publikováno v:
The Yale Journal of Biology and Medicine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::18fde0f69c0e9f2e4fb8ec73caa52b29
http://europepmc.org/articles/PMC3848097
http://europepmc.org/articles/PMC3848097