Výsledky vyhledávání - "Focko F. G. Rommerts"

The development of rat Leydig cell progenitors in vitro: how essential is luteinising hormone?

Autor: Mieke de Boer-Brouwer, Eddy Rijntjes, Katja J. Teerds, Focko F. G. Rommerts, Margarita B Veldhuizen-Tsoerkan

Publikováno v: Journal of Endocrinology 194 (2007) 3
Journal of Endocrinology, 194(3), 579-593

Luteinising hormone (LH) appears to be important for the establishment of the adult-type Leydig cell population. The role of LH in the initial steps of stem Leydig cell/precursor cell differentiation is less clear. The aim of the present study was to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8786d2342cea6dfb4f8d00370b7791e1
https://doi.org/10.1677/joe-06-0084

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Implications of Progesterone Metabolism in MA-10 Cells for Accurate Measurement of the Rate of Steroidogenesis

Autor: Paul N. Span, Steven R. King, Focko F. G. Rommerts

Publikováno v: Endocrinology, 142, 12, pp. 5236-42
Endocrinology, 142, 5236-42
Endocrinology, 142(12), 5236-5242. Endocrine Society

Item does not contain fulltext In virtually all studies with MA-10 cells, progesterone RIAs have been used to measure steroid synthesis. To test whether progesterone is a stable end product, we investigated the metabolism of added tritiated progester

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afb099de2caa17fda03cf3eac9e50f18
https://doi.org/10.1210/endo.142.12.8545

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Ethane dimethane sulfonate and NNN′N′-Tetrakis-(2-Pyridylmethyl)Ethylenediamine inhibit steroidogenic acute regulatory (StAR) protein expression in MA-10 leydig cells and rat sertoli cells

Autor: Douglas M. Stocco, Steven R. King, Focko F. G. Rommerts, Joseph Orly, James C. Hutson, Sarah L. Ford

Publikováno v: Endocrine Research, 24(3&4), 469-478. Informa Healthcare

Apoptosis inhibits steroid biosynthesis, but it is not clear how the Steroidogenic Acute Regulatory (StAR) protein, is affected. To characterize StAR expression during apoptosis, mouse MA-10 Leydig tumor cells were treated with ethane dimethane sulfo

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https://doi.org/10.3109/07435809809032635

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Low Levels of Follicle-Stimulating Hormone Receptor-Activation Inhibitors in Serum and Follicular Fluid from Normal Controls and Anovulatory Patients with or without Polycystic Ovary Syndrome1

Autor: P.M. ten Hacken, Focko F. G. Rommerts, Bart C.J.M. Fauser, Inger B. Schipper

Publikováno v: The Journal of Clinical Endocrinology & Metabolism. 82:1325-1331

In patients with normogonadotropic anovulation, either with or without polycystic ovary syndrome (PCOS), factors interfering with FSH action may be involved in arrested follicle development. The aim of this study is to assess whether factors inhibiti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a3e628e5595c8ea3aab8a79824b60ed9
https://doi.org/10.1210/jcem.82.5.3922

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Application of a CHO cell line transfected with the human FSH receptor for the measurement of specific FSH receptor activation inhibitors in human serum

Autor: P.M. ten Hacken, Bart C.J.M. Fauser, Focko F. G. Rommerts, Inger B. Schipper

Publikováno v: Journal of Endocrinology. 150:505-514

Effects of FSH on ovarian follicular development can be modulated by factors present in serum or by locally produced factors in follicular fluid. Some of these factors may act directly on the FSH receptor. A Chinese hamster ovary cell line (CHO-F3B4)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb29a8e1df18c40925743df74e5b267f
https://doi.org/10.1677/joe.0.1500505

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Micro-Volume Time-Resolved Fluorescence Spectroscopy Using a Confocal Synchrotron Radiation Microscope

Autor: David A. Shaw, Cornelis J. R. Van Der Oord, Yehudi K. Levine, Ian H. Munro, Focko F. G. Rommerts, Hans C. Gerritsen

Publikováno v: Applied Spectroscopy. 49:1469-1473

The confocal microscope SYCLOPS (SYCLOPS is not an acronym although the first syllable is derived from its main light source, a synchrotron radiation source) at the Daresbury Science and Engineering Research Council (SERC) Laboratory, U.K., has been

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https://doi.org/10.1366/0003702953965597

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Luteinizing hormone induction of the cholesterol side-chain cleavage enzyme in cultured immature rat Leydig cells: No role of insulin-like growth factor-I?

Autor: Lizzy van Haren, Focko F. G. Rommerts, J.Franny Flinterman, Joseph Orly

Publikováno v: Molecular and Cellular Endocrinology. 87:57-67

Long-term inductive effects of luteinizing hormone (LH) on cholesterol side-chain cleavage (CSCC) enzyme activity were studied, using cultured Leydig cells isolated from 21-day-old rats. Particular reference was given to the role of insulin-like grow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9576eed75841179adb24d206741b59b7
https://doi.org/10.1016/0303-7207(92)90233-v

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Testicular Leydig cells in vitro secrete only inhibin α-subunits, whereas Leydig cell tumors can secrete bioactive inhibin

Autor: A.J. Grootenhuis, Focko F. G. Rommerts, F. H. De Jong, M. A. Timmerman, J. P. De Winter, I. A. Klaij, H.M.J. Vanderstichele

Publikováno v: Molecular and Cellular Endocrinology. 83:105-115

The secretion of inhibin and inhibin-related proteins by testicular Leydig cells was studied by estimation of inhibin immunoreactivity and bioactivity in spent media of preparations of immature and mature rat Leydig cells and of tumor Leydig cells. I

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https://doi.org/10.1016/0303-7207(92)90151-u

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The stimulatory effect of albumin on luteinizing hormone-stimulated Leydig cell steroid production depends on its fatty acid content and correlates with conformational changes

Autor: Marcel J.E. Fischer, Rene F. van der Linden, Lambert H.M. Janssen, Roel Melsert, Octaaf J.M. Bos, Jos W. Hoogerbrugge, Jaap Wilting, Focko F. G. Rommerts

Publikováno v: Molecular and Cellular Endocrinology. 82:23-32

__Abstract__ The effects of purified albumin species and albumin fragments (0.2–1% w/v) on short-term (4 h) steroid secretion by immature rat Leydig cells, in the presence of a maximally stimulating dose of luteinizing hormone (LH), were investigat

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https://doi.org/10.1016/0303-7207(91)90005-d

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Short-term stimulatory effect of sertoli cell conditioned medium on leydig cell steroidogenesis is not mediated by inhibin

Autor: M. A. Timmerman, Roel Melsert, F. H. De Jong, Focko F. G. Rommerts, A.J. Grootenhuis, Jos W. Hoogerbrugge

Publikováno v: Journal of Steroid Biochemistry. 36:445-449

Addition of concentrated rat Sertoli cell conditioned medium (rSCCM) to isolated Leydig cells from immature rats stimulated steroid production more than 13-fold within 4h. LH-stimulated steroidogenesis was not enhanced by addition of rSCCM. The biolo

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https://doi.org/10.1016/0022-4731(90)90086-8

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