Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Focco, van den Akker"'
Autor:
Hua-Lin Zhou, Alfred Hausladen, Puneet Anand, Malligarjunan Rajavel, Colin T. Stomberski, Rongli Zhang, Richard T. Premont, William J. Greenlee, Focco van den Akker, Jonathan S. Stamler
Publikováno v:
Journal of Medicinal Chemistry. 66:5657-5668
Autor:
Malligarjunan Rajavel, Vijay Kumar, Ha Nguyen, Jacob Wyatt, Steven H. Marshall, Krisztina M. Papp-Wallace, Prasad Deshpande, Satish Bhavsar, Ravindra Yeole, Sachin Bhagwat, Mahesh Patel, Robert A. Bonomo, Focco van den Akker
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
Antibiotic resistance is a significant clinical problem. Developing novel antibiotics that overcome known resistance mechanisms is highly desired.
Externí odkaz:
https://doaj.org/article/4aa59e08d52045aea5cd17d19b97f5ff
Autor:
Vijay Kumar, Samantha L. Viviani, Jeeda Ismail, Shreya Agarwal, Robert A. Bonomo, Focco van den Akker
Publikováno v:
PLoS ONE, Vol 16, Iss 10 (2021)
Antimicrobial resistance (AMR) mediated by β-lactamases is the major and leading cause of resistance to penicillins and cephalosporins among Gram-negative bacteria. β-Lactamases, periplasmic enzymes that are widely distributed in the bacterial worl
Externí odkaz:
https://doaj.org/article/5ef9afab97ba4382a6c2b433c17fa67c
Publikováno v:
Protein Science.
Autor:
Melissa D. Barnes, Vijay Kumar, Christopher R. Bethel, Samir H. Moussa, John O’Donnell, Joseph D. Rutter, Caryn E. Good, Kristine M. Hujer, Andrea M. Hujer, Steve H. Marshall, Barry N. Kreiswirth, Sandra S. Richter, Philip N. Rather, Michael R. Jacobs, Krisztina M. Papp-Wallace, Focco van den Akker, Robert A. Bonomo
Publikováno v:
mBio, Vol 10, Iss 2 (2019)
ABSTRACT Multidrug-resistant (MDR) Acinetobacter spp. poses a significant therapeutic challenge in part due to the presence of chromosomally encoded β-lactamases, including class C Acinetobacter-derived cephalosporinases (ADC) and class D oxacillina
Externí odkaz:
https://doaj.org/article/e9fdc0602a7742b6a7a1c6dfc92d0ab3
Autor:
Tahani A. Alsenani, María Margarita Rodríguez, Barbara Ghiglione, Magdalena A. Taracila, Maria F. Mojica, Laura J. Rojas, Andrea M. Hujer, Gabriel Gutkind, Christopher R. Bethel, Philip N. Rather, Maria Luisa Introvigne, Fabio Prati, Emilia Caselli, Pablo Power, Focco van den Akker, Robert A. Bonomo
Publikováno v:
Antimicrobial Agents and Chemotherapy. 67
Design of novel β-lactamase inhibitors (BLIs) is one of the currently accepted strategies to combat the threat of cephalosporin and carbapenem resistance in Gram-negative bacteria. B oronic a cid t ransition s tate i nhibitors (BATSIs) are competiti
Autor:
Focco van den Akker, Robert A. Bonomo
Publikováno v:
Frontiers in Microbiology, Vol 9 (2018)
As a bacterial resistance strategy, serine β-lactamases have evolved from cell wall synthesizing enzymes known as penicillin-binding proteins (PBP), by not only covalently binding β-lactam antibiotics but, also acquiring mechanisms of deacylating t
Externí odkaz:
https://doaj.org/article/ebe5642738074a62a866fe5dbe4e8d1c
Autor:
Jagamya Vijayaraghavan, Vijay Kumar, Nikhil P Krishnan, Ross T Kaufhold, Ximin Zeng, Jun Lin, Focco van den Akker
Publikováno v:
PLoS ONE, Vol 13, Iss 5, p e0197136 (2018)
The bacterial soluble lytic transglycosylase (LT) breaks down the peptidoglycan (PG) layer during processes such as cell division. We present here crystal structures of the soluble LT Cj0843 from Campylobacter jejuni with and without bulgecin A inhib
Externí odkaz:
https://doaj.org/article/fe969b41c6a14f84a932d71da1311b3e
Autor:
Mijoon Lee, Shahriar Mobashery, Dusan Hesek, Focco van den Akker, Jacob Boorman, Elena Lastochkin, Ximin Zeng, Jun Lin, Snigdha A. Mathure, Vijay Kumar
Publikováno v:
Biochemistry. 60:1133-1144
The soluble lytic transglycosylase Cj0843c from Campylobacter jejuni breaks down cell-wall peptidoglycan (PG). Its nonhydrolytic activity sustains cell-wall remodeling and repair. We report herein our structure-function studies probing the substrate
Publikováno v:
Antibiotics, Vol 8, Iss 3, p 145 (2019)
Carbapenem-resistant Enterobacteriaceae are a significant threat to public health, and a major resistance determinant that promotes this phenotype is the production of the OXA-48 carbapenemase. The activity of OXA-48 towards carbapenems is a puzzling
Externí odkaz:
https://doaj.org/article/30f446f4ab35407bb06e81b717c06092