Combined dual effect of modulation of human neutrophils' oxidative burst and inhibition of colon cancer cells proliferation by hydroxycinnamic acid derivatives.

Autor: Tavares-da-Silva EJ; Pharmaceutical Chemistry Group, Faculty of Pharmacy, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal; CNC.IBILI, University of Coimbra, Portugal. Electronic address: etavares@ff.uc.pt., Varela CL; Pharmaceutical Chemistry Group, Faculty of Pharmacy, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal., Pires AS; CNC.IBILI, University of Coimbra, Portugal; Biophysics Institute, IBILI-Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal; CIMAGO, FMUC-Faculty of Medicine, University of Coimbra, Portugal., Encarnação JC; Biophysics Institute, IBILI-Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal; CIMAGO, FMUC-Faculty of Medicine, University of Coimbra, Portugal., Abrantes AM; CNC.IBILI, University of Coimbra, Portugal; Biophysics Institute, IBILI-Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal; CIMAGO, FMUC-Faculty of Medicine, University of Coimbra, Portugal., Botelho MF; CNC.IBILI, University of Coimbra, Portugal; Biophysics Institute, IBILI-Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal; CIMAGO, FMUC-Faculty of Medicine, University of Coimbra, Portugal., Carvalho RA; CNC.IBILI, University of Coimbra, Portugal; Department of Life Sciences, Faculty of Science and Technology, University of Coimbra, Portugal., Proença C; UCIBIO, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal., Freitas M; UCIBIO, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal., Fernandes E; UCIBIO, REQUIMTE, Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, Porto, Portugal., Roleira FM; Pharmaceutical Chemistry Group, Faculty of Pharmacy, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal; CNC.IBILI, University of Coimbra, Portugal. Electronic address: froleira@ff.uc.pt.

Publikováno v: Bioorganic & medicinal chemistry [Bioorg Med Chem] 2016 Aug 15; Vol. 24 (16), pp. 3556-64. Date of Electronic Publication: 2016 May 30.

Exemestane metabolites suppress growth of estrogen receptor-positive breast cancer cells by inducing apoptosis and autophagy: A comparative study with Exemestane.

Autor: Amaral C; UCIBIO,REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal., Lopes A; Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal., Varela CL; Pharmaceutical Chemistry Group, Faculty of Pharmacy, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal., da Silva ET; Pharmaceutical Chemistry Group, Faculty of Pharmacy, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal; CNC.IBILI, University of Coimbra, Coimbra, Portugal., Roleira FM; Pharmaceutical Chemistry Group, Faculty of Pharmacy, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal; CNC.IBILI, University of Coimbra, Coimbra, Portugal., Correia-da-Silva G; UCIBIO,REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal., Teixeira N; UCIBIO,REQUIMTE, Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, 228, 4050-313 Porto, Portugal. Electronic address: natercia@ff.up.pt.

Publikováno v: The international journal of biochemistry & cell biology [Int J Biochem Cell Biol] 2015 Dec; Vol. 69, pp. 183-95. Date of Electronic Publication: 2015 Oct 26.

Exemestane metabolites: Synthesis, stereochemical elucidation, biochemical activity and anti-proliferative effects in a hormone-dependent breast cancer cell line.

Autor: Varela CL; CEF, Center for Pharmaceutical Studies & Pharmaceutical Chemistry Group, Faculty of Pharmacy, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal., Amaral C; Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal; Institute for Molecular and Cell Biology (IBMC), University of Porto, Rua do Campo Alegre, 823, 4150-180 Porto, Portugal., Tavares da Silva E; CEF, Center for Pharmaceutical Studies & Pharmaceutical Chemistry Group, Faculty of Pharmacy, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal., Lopes A; Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal; Institute for Molecular and Cell Biology (IBMC), University of Porto, Rua do Campo Alegre, 823, 4150-180 Porto, Portugal., Correia-da-Silva G; Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal; Institute for Molecular and Cell Biology (IBMC), University of Porto, Rua do Campo Alegre, 823, 4150-180 Porto, Portugal., Carvalho RA; Department of Life Sciences, Faculty of Science and Technology, University of Coimbra, 3001-401, Portugal; Center for Neuroscience and Cell Biology (CNC), University of Coimbra, 3001-401, Portugal., Costa SC; CEF, Center for Pharmaceutical Studies & Pharmaceutical Chemistry Group, Faculty of Pharmacy, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal., Roleira FM; CEF, Center for Pharmaceutical Studies & Pharmaceutical Chemistry Group, Faculty of Pharmacy, University of Coimbra, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal., Teixeira N; Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, n° 228, 4050-313 Porto, Portugal; Institute for Molecular and Cell Biology (IBMC), University of Porto, Rua do Campo Alegre, 823, 4150-180 Porto, Portugal. Electronic address: natercia@ff.up.pt.

Publikováno v: European journal of medicinal chemistry [Eur J Med Chem] 2014 Nov 24; Vol. 87, pp. 336-45. Date of Electronic Publication: 2014 Sep 28.

Design, synthesis and biochemical studies of new 7α-allylandrostanes as aromatase inhibitors.

Autor: Varela CL; CEF, Center for Pharmaceutical Studies, Pharmaceutical Chemistry Group, Faculty of Pharmacy, University of Coimbra, 3000-548 Coimbra, Portugal., Amaral C, Correia-da-Silva G, Carvalho RA, Teixeira NA, Costa SC, Roleira FM, Tavares-da-Silva EJ

Publikováno v: Steroids [Steroids] 2013 Jul; Vol. 78 (7), pp. 662-9. Date of Electronic Publication: 2013 Mar 13.

Development of a new gas chromatography-mass spectrometry (GC-MS) methodology for the evaluation of 5α-reductase activity.

Autor: Amaral C; Laboratory of Biochemistry, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, Rua Jorge Viterbo Ferreira, No. 228, 4050-313 Porto, Portugal., Cunha SC, Fernandes JO, Tavares da Silva E, Roleira FM, Teixeira N, Correia-da-Silva G

Publikováno v: Talanta [Talanta] 2013 Mar 30; Vol. 107, pp. 154-61. Date of Electronic Publication: 2013 Jan 02.