Zobrazeno 1 - 10
of 1 889
pro vyhledávání: '"Fluoropyrimidine]"'
Autor:
Kaname Miyashita, Seijiro Shioi, Tatsuhiro Kajitani, Yumiko Koi, Mototsugu Shimokawa, Akitaka Makiyama, Shinya Oda, Taito Esaki
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Microsatellite instability (MSI) is now widely used as an indispensable biomarker. However, the relationship between MSI-H (high) and defective DNA mismatch repair (MMR) is not as straightforward as has been expected. Genome-edited cells car
Externí odkaz:
https://doaj.org/article/0cfc9a4391194efab3c41befb1974e3c
Autor:
Cassandra White, Hannah Wardill, Christine Paul, Timothy Price, Christos Karapetis, Mark Nalder, Matthew E. Burge, Ann Thomas, Chris Oldmeadow, Daniel Barker, Laura C. Edney, Janet Coller, Joanne Bowen, Cheri Ostroff, Bruce Cheek, Mel Carlson, Trumaine Rankmore, Adnan Nagrial, Stephen Clarke, Lorraine Chantrill, Stephen Ackland, Rodney J. Scott
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-10 (2024)
Abstract Background Fluoropyrimidine (FP) chemotherapies are commonly prescribed for upper and lower gastrointestinal, breast and head and neck malignancies. Over 16,000 people with cancer require FP chemotherapies per annum in Australia. Between 10
Externí odkaz:
https://doaj.org/article/4dd039073fb249cbbecad007e14e1be9
Autor:
Wei Wang, Guixian Wu, Wujun Luo, Ling Lin, Chao Zhou, Guifei Yao, Meifang Chen, Xiaomai Wu, Ziran Chen, Junhui Ye, Haihua Yang, Dongqing Lv
Publikováno v:
BMC Cancer, Vol 24, Iss 1, Pp 1-9 (2024)
Abstract Background Patients with small-cell lung cancer (SCLC) have few treatment options and dismal overall survival (OS) after failed platinum-based chemotherapy. Methods The eligibility criteria of this phase II clinical trial included patients w
Externí odkaz:
https://doaj.org/article/0eedeaeb2cd44b6fb7feefbe88cb19b6
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Dihydropyrimidine dehydrogenase (DPD, encoded by the DPYD gene) is the rate-limiting enzyme for the detoxification of fluoropyrimidines (FLs). Rs4294451 is a regulatory DPYD polymorphism that has recently been functionally characterized and associate
Externí odkaz:
https://doaj.org/article/fbf1d887f3d8471c9a2179dce6f3e98f
Autor:
Jennifer M. Finan, Roberto Di Niro, Soon Young Park, Kang Jin Jeong, Madeline D. Hedberg, Alexander Smith, Grace A. McCarthy, Alex O. Haber, John Muschler, Rosalie C. Sears, Gordon B. Mills, William H. Gmeiner, Jonathan R. Brody
Publikováno v:
Cancer Biology & Therapy, Vol 25, Iss 1 (2024)
Pancreatic ductal adenocarcinoma (PDAC) is a lethal disease soon to become the second leading cause of cancer deaths in the US. Beside surgery, current therapies have narrow clinical benefits with systemic toxicities. FOLFIRINOX is the current standa
Externí odkaz:
https://doaj.org/article/31179cb813084425aaab19da48c81dcf
Autor:
Hiroyuki Kozai, Hirokazu Ogino, Atsushi Mitsuhashi, Na Thi Nguyen, Yuki Tsukazaki, Yohei Yabuki, Ryohiko Ozaki, Hiroto Yoneda, Seidai Sato, Masaki Hanibuchi, Tsutomu Shinohara, Hiroshi Nokihara, Yasuhiko Nishioka
Publikováno v:
Thoracic Cancer, Vol 15, Iss 5, Pp 369-378 (2024)
Abstract Background Immune checkpoint inhibitors (ICIs) are a revolutionary paradigm in the treatment of thoracic malignancies and chemoimmunotherapy is a current standard care in this field. Chemotherapeutic agents are known to induce not only direc
Externí odkaz:
https://doaj.org/article/3b039c22a72a49ee860a78baa3226a06
Publikováno v:
Frontiers in Pharmacology, Vol 15 (2024)
Externí odkaz:
https://doaj.org/article/af69fbc3464e47bb88a244123130bb2a
Autor:
Elena De Mattia, Jerry Polesel, Marco Silvestri, Rossana Roncato, Lucia Scarabel, Stefano Calza, Michele Spina, Fabio Puglisi, Giuseppe Toffoli, Erika Cecchin
Publikováno v:
Human Genomics, Vol 17, Iss 1, Pp 1-15 (2023)
Abstract Background Despite a growing number of publications highlighting the potential impact on the therapy outcome, rare genetic variants (minor allele frequency
Externí odkaz:
https://doaj.org/article/43e97f65f43942da9fd70a4799972bf0
Autor:
Jing Ning, Can Li, Peng Yu, Jingjing Cui, Xiaodan Xu, Yan Jia, Panli Zuo, Jiahe Tian, Lukas Kenner, Baixuan Xu
Publikováno v:
Insights into Imaging, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Purpose To investigate the clinical value of radiomic analysis on [18F]FDG and [18F]FLT PET on the differentiation of [18F]FDG-avid benign and malignant pulmonary nodules (PNs). Methods Data of 113 patients with inconclusive PNs based on pre
Externí odkaz:
https://doaj.org/article/cd2e3ff0754d4614b9219387e486d5fa
Autor:
Bingxue Yang, Xinran Xie, Zhaoyu Wu, Dazhao Lv, Jiajun Hu, Yuyun Chen, Jiaxing Li, Shuyue Luo, Jiacheng Li, Jie Luo, Shiyi Zhang
Publikováno v:
Genes and Diseases, Vol 10, Iss 6, Pp 2557-2571 (2023)
Hand-foot syndrome (HFS) is a widely recognized dose-limiting cutaneous toxicity effect of fluoropyrimidine chemotherapy agents that impairs clinical benefits and treatment outcomes. Even though the cause and pathophysiology of HFS are relatively wid
Externí odkaz:
https://doaj.org/article/b9bf1fb4ca2745d5a4676de23f8b27ea