Zobrazeno 1 - 10
of 3 649
pro vyhledávání: '"Fluid shear stress"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Low fluid shear stress (FSS, ≤ 2 dyn/cm2) has been shown to exert protective effects on chondrocytes, but the underlying molecular mechanisms remain unclear. This study aimed to elucidate the mechanisms by which FSS promotes chondrocyte pr
Externí odkaz:
https://doaj.org/article/ac6933db158240cdababc1a89789f519
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 19, Iss 1, Pp 1-13 (2024)
Abstract Objective This study investigated the protective effects of low fluid shear stress (FSS ≤ 2 dyn/cm²) against interleukin-1β (IL-1β)-induced chondrocyte apoptosis and explored the underlying molecular mechanisms. Methods Chondrocytes wer
Externí odkaz:
https://doaj.org/article/2fca0dbedc6e45dda393ce0683623e38
Publikováno v:
International Dental Journal, Vol 74, Iss 3, Pp 597-606 (2024)
Objectives: The aim of this study was to investigate the molecular mechanism underlying odontoblast damage repair in dentin hypersensitivity (DH) and the role of Yes-associated protein (YAP) in this process. Methods: The DH model was constructed in S
Externí odkaz:
https://doaj.org/article/9ee8b607eeba466db555c33a19c0ad54
Autor:
Claudia Tanja Mierke
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
The endothelial cells of the blood circulation are exposed to hemodynamic forces, such as cyclic strain, hydrostatic forces, and shear stress caused by the blood fluid’s frictional force. Endothelial cells perceive mechanical forces via mechanosens
Externí odkaz:
https://doaj.org/article/2f9d845a2b534b9192e159f1e7b2a9bf
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Cell-based therapies represent the current frontier of biomedical innovations, with the technologies required underpinning treatments as broad as CAR-T cell therapies, stem cell treatments, genetic therapies and mRNA manufacture. A key bottleneck in
Externí odkaz:
https://doaj.org/article/80e138cf45c0402d85e2a7b20dea8bbe
Publikováno v:
Frontiers in Physiology, Vol 15 (2024)
Recent advances in organ chip (or, “organ-on-a-chip”) technologies and microphysiological systems (MPS) have enabled in vitro investigation of endothelial cell function in biomimetic three-dimensional environments under controlled fluid flow cond
Externí odkaz:
https://doaj.org/article/5cfadacadadf467eab0bf77480d72c59
Autor:
Yinyin Chen, Yushun Gong, Jia Zou, Guoli Li, Fan Zhang, Yiya Yang, Yumei Liang, Wenni Dai, Liyu He, Hengcheng Lu
Publikováno v:
Genes and Diseases, Vol 11, Iss 4, Pp 101101- (2024)
Obesity-related glomerulopathy (ORG) is an independent risk factor for chronic kidney disease and even progression to end-stage renal disease. Efforts have been undertaken to elucidate the mechanisms underlying the development of ORG and substantial
Externí odkaz:
https://doaj.org/article/09ec6bd03f3c4243b1b7232e57b7806a
Publikováno v:
BMC Musculoskeletal Disorders, Vol 25, Iss 1, Pp 1-13 (2024)
Abstract Background The purpose of this study was to investigate the effects of four different doses of verapamil on the mechanical behaviors of solid and the characteristics of fluid flow in cancellous bone of distal femur of type 2 diabetes rats un
Externí odkaz:
https://doaj.org/article/2c2ab6e5fbab49bb952c9ff37aa12ecd
Autor:
Xiaoqiao Xu, Yi Guo, Peiqi Liu, Hui Zhang, Yijie Wang, Zhen Li, Yukun Mei, Lin Niu, Ruirui Liu
Publikováno v:
International Dental Journal, Vol 74, Iss 1, Pp 71-80 (2024)
Objectives: The aim of this research was to investigate the functions of Piezo channels in dentin defect, including mechanical signalling and odontoblast responses. Methods: Rat dentin-defect models were constructed, and spatiotemporal expression of
Externí odkaz:
https://doaj.org/article/2cb147f92be74d55a3946be4b08bf744
Autor:
Shenghui Kang, Xiaoyu Wu, Hang Qi, Kai Yang, Ruoyu Feng, Wenlan Guo, Chen Sun, Xuexin Duan, Yanyan Wang
Publikováno v:
Small Structures, Vol 5, Iss 5, Pp n/a-n/a (2024)
Development of a micromodel that recapitulates multiple mechanical properties to mimic the complex mechanical microenvironment is crucial for cell‐based research. Herein, a microsystem combining structure of hydrogel matrix and acoustic streaming (
Externí odkaz:
https://doaj.org/article/93c8708efdad47989d34fe455cbf7ebe