Brown fat ATP-citrate lyase links carbohydrate availability to thermogenesis and guards against metabolic stress.

Autor: Korobkina ED; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Calejman CM; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Haley JA; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Kelly ME; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA., Li H; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Gaughan M; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Chen Q; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Pepper HL; Aging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA., Ahmad H; Aging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA., Boucher A; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Fluharty SM; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Lin TY; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Lotun A; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Peura J; Division of Hematology-Oncology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Trefely S; Department of Cancer Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Green CR; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA., Vo P; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Semenkovich CF; Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St. Louis, MO, USA., Pitarresi JR; Division of Hematology-Oncology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA., Spinelli JB; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Aydemir O; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Metallo CM; Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA.; Molecular and Cellular Biology Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA., Lynes MD; MaineHealth Institute for Research, Scarborough, ME, USA., Jang C; Department of Biological Chemistry, University of California Irvine, Irvine, CA, USA., Snyder NW; Aging + Cardiovascular Discovery Center, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA., Wellen KE; Department of Cancer Biology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.; Abramson Family Cancer Research Institute, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA., Guertin DA; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA. david.guertin@umassmed.edu.; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, USA. david.guertin@umassmed.edu.

Publikováno v: Nature metabolism [Nat Metab] 2024 Oct 14. Date of Electronic Publication: 2024 Oct 14.

Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1.

Autor: Luciano AK; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA., Korobkina ED; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA., Lyons SP; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA., Haley JA; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA., Fluharty SM; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA., Jung SM; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA., Kettenbach AN; Department of Biochemistry and Cell Biology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA; Norris Cotton Cancer Center, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA., Guertin DA; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA. Electronic address: David.Guertin@umassmed.edu.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2022 Oct; Vol. 298 (10), pp. 102379. Date of Electronic Publication: 2022 Aug 13.