Zobrazeno 1 - 10
of 168
pro vyhledávání: '"Floyd H Gilles"'
Autor:
Jingying eXu, Ashley Sloane Margol, Anju eShukla, Xiuhai eRen, Jonathan L Finlay, Mark D Krieger, Floyd H Gilles, Fergus J Couch, Meraj eAziz, Eric T Fung, Shahab eAsgharzadeh, Michael T Barrett, Anat eErdreich-Epstein
Publikováno v:
Frontiers in Oncology, Vol 5 (2015)
Medulloblastoma, the most common malignant brain tumor in children, occurs with increased frequency in individuals with Fanconi anemia who have biallelic germline mutations in BRCA2. We describe an 8 year old child who had disseminated anaplastic med
Externí odkaz:
https://doaj.org/article/9922ef4f37724471b1ab819b119207a3
Autor:
Shahab Asgharzadeh, Richard Sposto, Alexander R. Judkins, Floyd H. Gilles, Maryam Fouladi, Rachid Drissi, Mark D. Krieger, Anat Erdreich-Epstein, Jonathan L. Finlay, Girish Dhall, Marzieh Vali, Rebekah J. Kennedy, Long T. Hung, Janahan Gnanachandran, Nathan J. Robison, Ashley S. Margol
Purpose: Medulloblastoma in children can be categorized into at least four molecular subgroups, offering the potential for targeted therapeutic approaches to reduce treatment-related morbidities. Little is known about the role of tumor microenvironme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd31f55c5e74e01bfea6921a6e0eb52e
https://doi.org/10.1158/1078-0432.c.6523955.v1
https://doi.org/10.1158/1078-0432.c.6523955.v1
Autor:
Shahab Asgharazadeh, Richard Sposto, Marcel Kool, Stefan M. Pfister, David T.W. Jones, Alexander R. Judkins, Mark D. Krieger, Ashley S. Margol, Gregory M. Shackleford, Jemily Malvar, Lingyun Ji, Floyd H. Gilles, Mathew Schur, Tom B. Davidson, Jingying Xu, Hong Zhou, Xiuhai Ren, Nathan Robison, Anat Erdreich-Epstein
PDF file 92K, Supplemental Fig 5: Expression of PID1 protein in human brain tumors and cell lines
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d82bea2b8c767c454086e43a6cb428cd
https://doi.org/10.1158/1078-0432.22449965
https://doi.org/10.1158/1078-0432.22449965
Autor:
Shahab Asgharazadeh, Richard Sposto, Marcel Kool, Stefan M. Pfister, David T.W. Jones, Alexander R. Judkins, Mark D. Krieger, Ashley S. Margol, Gregory M. Shackleford, Jemily Malvar, Lingyun Ji, Floyd H. Gilles, Mathew Schur, Tom B. Davidson, Jingying Xu, Hong Zhou, Xiuhai Ren, Nathan Robison, Anat Erdreich-Epstein
PDF file - 190K, Supplemental Fig 2: Proneural and Neural GBMs have higher PID1 mRNA; higher PID1 mRNA correlates with higher OS in patients with gliomas.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fc273645c3c2cb62aa3119bfff91078
https://doi.org/10.1158/1078-0432.22449974.v1
https://doi.org/10.1158/1078-0432.22449974.v1
Autor:
Shahab Asgharzadeh, Richard Sposto, Alexander R. Judkins, Floyd H. Gilles, Maryam Fouladi, Rachid Drissi, Mark D. Krieger, Anat Erdreich-Epstein, Jonathan L. Finlay, Girish Dhall, Marzieh Vali, Rebekah J. Kennedy, Long T. Hung, Janahan Gnanachandran, Nathan J. Robison, Ashley S. Margol
Supplemental Methods and Supplemental Figures 1-9 Supplemental Figure 1. Overview of samples studies and 31-gene signature development Supplemental Figure. 2. Non-negative matrix factorization (NMF) analysis of the combined cohort of medulloblastoma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcc400b3af0732be204c09018d938fe0
https://doi.org/10.1158/1078-0432.22458464
https://doi.org/10.1158/1078-0432.22458464
Autor:
Shahab Asgharazadeh, Richard Sposto, Marcel Kool, Stefan M. Pfister, David T.W. Jones, Alexander R. Judkins, Mark D. Krieger, Ashley S. Margol, Gregory M. Shackleford, Jemily Malvar, Lingyun Ji, Floyd H. Gilles, Mathew Schur, Tom B. Davidson, Jingying Xu, Hong Zhou, Xiuhai Ren, Nathan Robison, Anat Erdreich-Epstein
PDF file - 159K, Supplemental Fig 1: PID1 mRNA is lower in less favorable medulloblastomas in two additional independent datasets; PID1 mRNA correlates with rf-PFS when analyzing CHLA medulloblastomas by tertiles.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bc3d85666d5ca39bff7ed5663e6d04d
https://doi.org/10.1158/1078-0432.22449977.v1
https://doi.org/10.1158/1078-0432.22449977.v1
Autor:
Shahab Asgharazadeh, Richard Sposto, Marcel Kool, Stefan M. Pfister, David T.W. Jones, Alexander R. Judkins, Mark D. Krieger, Ashley S. Margol, Gregory M. Shackleford, Jemily Malvar, Lingyun Ji, Floyd H. Gilles, Mathew Schur, Tom B. Davidson, Jingying Xu, Hong Zhou, Xiuhai Ren, Nathan Robison, Anat Erdreich-Epstein
PDF file - 17K, Supplemental Fig 4: PID1 increases the proportion of cells in Sub G0/G1 in CHLA-259 medulloblastoma cells.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61093f972bcf75092590c405fa1c3215
https://doi.org/10.1158/1078-0432.22449968
https://doi.org/10.1158/1078-0432.22449968
Autor:
Shahab Asgharazadeh, Richard Sposto, Marcel Kool, Stefan M. Pfister, David T.W. Jones, Alexander R. Judkins, Mark D. Krieger, Ashley S. Margol, Gregory M. Shackleford, Jemily Malvar, Lingyun Ji, Floyd H. Gilles, Mathew Schur, Tom B. Davidson, Jingying Xu, Hong Zhou, Xiuhai Ren, Nathan Robison, Anat Erdreich-Epstein
Purpose: We present here the first report of PID1 (Phosphotyrosine Interaction Domain containing 1; NYGGF4) in cancer. PID1 was identified in 2006 as a gene that modulates insulin signaling and mitochondrial function in adipocytes and muscle cells.Ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c143c3c543fc8e4407e7c83c12e25822
https://doi.org/10.1158/1078-0432.c.6521810
https://doi.org/10.1158/1078-0432.c.6521810
Autor:
Shahab Asgharazadeh, Richard Sposto, Marcel Kool, Stefan M. Pfister, David T.W. Jones, Alexander R. Judkins, Mark D. Krieger, Ashley S. Margol, Gregory M. Shackleford, Jemily Malvar, Lingyun Ji, Floyd H. Gilles, Mathew Schur, Tom B. Davidson, Jingying Xu, Hong Zhou, Xiuhai Ren, Nathan Robison, Anat Erdreich-Epstein
PDF file - 440K, Supplemental Table 1: Characteristics of the CHLA Medulloblastoma Patients. Supplemental Table 2: Neural and Proneural GBM subgroups have higher PID1 mRNA compared to Classical and Mesenchymal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a79da4827af21a1d7b7b3d6849de249
https://doi.org/10.1158/1078-0432.22449959.v1
https://doi.org/10.1158/1078-0432.22449959.v1
Autor:
Shahab Asgharzadeh, Richard Sposto, Alexander R. Judkins, Floyd H. Gilles, Maryam Fouladi, Rachid Drissi, Mark D. Krieger, Anat Erdreich-Epstein, Jonathan L. Finlay, Girish Dhall, Marzieh Vali, Rebekah J. Kennedy, Long T. Hung, Janahan Gnanachandran, Nathan J. Robison, Ashley S. Margol
Supplemental Tables 1-6 Supplemental Table 1. Patient and tumor characteristics Supplemental Table 2. TLDA design (45 genes) Supplemental Table 3. Information for samples evaluated using HuE Supplemental Table 4. TLDA 31-gene molecular classification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395bf4c22fc019c8766d21900debe252
https://doi.org/10.1158/1078-0432.22458461.v1
https://doi.org/10.1158/1078-0432.22458461.v1