Zobrazeno 1 - 10
of 149
pro vyhledávání: '"Floyd H Chilton"'
Autor:
Aki Hara, Eric Lu, Laurel Johnstone, Michelle Wei, Shudong Sun, Brian Hallmark, Joseph C Watkins, Hao Helen Zhang, Guang Yao, Floyd H Chilton
Publikováno v:
Bioinformatics and Biology Insights, Vol 18 (2024)
The secreted phospholipase A 2 (sPLA 2 ) isoform, sPLA 2 -IIA, has been implicated in a variety of diseases and conditions, including bacteremia, cardiovascular disease, COVID-19, sepsis, adult respiratory distress syndrome, and certain cancers. Give
Externí odkaz:
https://doaj.org/article/084929ee08834e83b670f9e2bc1b1a66
Autor:
Lindsay M Reynolds, Timothy D Howard, Ingo Ruczinski, Kanika Kanchan, Michael C Seeds, Rasika A Mathias, Floyd H Chilton
Publikováno v:
PLoS ONE, Vol 13, Iss 3, p e0194610 (2018)
Omega-6 (n-6) and omega-3 (n-3) long (≥ 20 carbon) chain polyunsaturated fatty acids (LC-PUFAs) play a critical role in human health and disease. Biosynthesis of LC-PUFAs from dietary 18 carbon PUFAs in tissues such as the liver is highly associate
Externí odkaz:
https://doaj.org/article/734b14a40ea54a2db2e2b484040ad7c3
Autor:
Elaheh Rahbar, Hannah C Ainsworth, Timothy D Howard, Gregory A Hawkins, Ingo Ruczinski, Rasika Mathias, Michael C Seeds, Susan Sergeant, James E Hixson, David M Herrington, Carl D Langefeld, Floyd H Chilton
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0180903 (2017)
Genetic variants near and within the fatty acid desaturase (FADS) cluster are associated with polyunsaturated fatty acid (PUFA) biosynthesis, levels of several disease biomarkers and risk of human disease. However, determining the functional mechanis
Externí odkaz:
https://doaj.org/article/6ec17c84d7ad4e4fac0d84c1dfa70594
Autor:
Timothy D Howard, Rasika A Mathias, Michael C Seeds, David M Herrington, James E Hixson, Lawrence C Shimmin, Greg A Hawkins, Matthew Sellers, Hannah C Ainsworth, Susan Sergeant, Leslie R Miller, Floyd H Chilton
Publikováno v:
PLoS ONE, Vol 9, Iss 5, p e97510 (2014)
Levels of omega-6 (n-6) and omega-3 (n-3), long chain polyunsaturated fatty acids (LcPUFAs) such as arachidonic acid (AA; 20:4, n-6), eicosapentaenoic acid (EPA; 20:5, n-3) and docosahexaenoic acid (DHA; 22:6, n-3) impact a wide range of biological a
Externí odkaz:
https://doaj.org/article/18d293a9fef546aaa83380f0020356e3
Autor:
Rasika A Mathias, Wenqing Fu, Joshua M Akey, Hannah C Ainsworth, Dara G Torgerson, Ingo Ruczinski, Susan Sergeant, Kathleen C Barnes, Floyd H Chilton
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44926 (2012)
Long chain polyunsaturated fatty acids (LC-PUFAs) are essential for brain structure, development, and function, and adequate dietary quantities of LC-PUFAs are thought to have been necessary for both brain expansion and the increase in brain complexi
Externí odkaz:
https://doaj.org/article/92f6be45a49443a288806bc73de4a571
Autor:
Chaojie Yang, Brian Hallmark, Jin Choul Chai, Timothy D. O’Connor, Lindsay M. Reynolds, Alexis C. Wood, Michael Seeds, Yii-Der Ida Chen, Lyn M. Steffen, Michael Y. Tsai, Robert C. Kaplan, Martha L. Daviglus, Lawrence J. Mandarino, Amanda M. Fretts, Rozenn N. Lemaitre, Dawn K. Coletta, Sarah A. Blomquist, Laurel M. Johnstone, Chandra Tontsch, Qibin Qi, Ingo Ruczinski, Stephen S. Rich, Rasika A. Mathias, Floyd H. Chilton, Ani Manichaikul
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Yang et al. examine whether genetic ancestry is associated with genetic variation in fatty acid desaturases and plasma phospholipid levels of long chain polyunsaturated fatty acids (LC-PUFAs) in Hispanic Americans. They find strong associations betwe
Externí odkaz:
https://doaj.org/article/490453d6665243aba801e3d3ea7f205f
Autor:
Floyd H. Chilton, Ani Manichaikul, Chaojie Yang, Timothy D. O'Connor, Laurel M. Johnstone, Sarah Blomquist, Susan M. Schembre, Susan Sergeant, Manja Zec, Michael Y. Tsai, Stephen S. Rich, Susan J. Bridgewater, Rasika A. Mathias, Brian Hallmark
Publikováno v:
Frontiers in Nutrition, Vol 8 (2022)
Human diets in developed countries such as the US have changed dramatically over the past 75 years, leading to increased obesity, inflammation, and cardiometabolic dysfunction. Evidence over the past decade indicates that the interaction of genetic v
Externí odkaz:
https://doaj.org/article/28f07f7d31ef4566a6bbf1e3ff248116
Autor:
Wood, Shabnam R. Momin, Mackenzie K. Senn, Ani Manichaikul, Chaojie Yang, Rasika Mathias, Mimi Phan, Stephen S. Rich, Susan Sergeant, Michael Seeds, Lindsay Reynolds, Floyd H. Chilton, Alexis C.
Publikováno v:
Nutrients; Volume 15; Issue 12; Pages: 2779
Linoleic acid (LA) is a primary n-6 polyunsaturated fatty acid (PUFA), which is of interest to nutritional professionals as it has been associated with health outcomes. However, as some LA-rich foods offer protection against chronic diseases such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::4d59be3406e5706b206a5c57adb1e826
Autor:
Michael C. Seeds, Timothy D. Howard, Floyd H. Chilton, Rahul Dutta, Kirsten N. Lake, Rasika A. Mathias, Brian Hallmark, Lindsay M. Reynolds
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Scientific Reports
Scientific Reports
Humans have undergone intense evolutionary selection to optimize their capacity to generate necessary quantities of long chain (LC-) polyunsaturated fatty acid (PUFA)-containing lipids. To better understand the impact of genetic variation within a lo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e71a212e96bdbab27ade1702b4a544ee
http://link.springer.com/article/10.1038/s41598-020-71948-1
http://link.springer.com/article/10.1038/s41598-020-71948-1
Autor:
Tammy L Mustin, Laurel Johnstone, Michael C. Seeds, Floyd H. Chilton, Priscilla Ivester, Rasika A. Mathias, Maggie L Bohannon, Susan Sergeant, Brian Hallmark, Ingo Ruczinski
Publikováno v:
Am J Clin Nutr
Background Unexplained heterogeneity in clinical trials has resulted in questions regarding the effectiveness of ɣ-linolenic acid (GLA)-containing botanical oil supplements. This heterogeneity may be explained by genetic variation within the fatty a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19a2a02ca9051d8805f91c6571d340c5
https://doi.org/10.1093/ajcn/nqaa023
https://doi.org/10.1093/ajcn/nqaa023