Structural and systems characterization of phosphorylation on metabolic enzymes identifies sex-specific metabolic reprogramming in obesity.

Autor: Tamir TY; Koch Institute for Integrative Cancer Research.; Center for Precision Cancer Medicine.; Department of Biological Engineering.; Massachusetts Institute of Technology, Cambridge, MA, USA., Chaudhary S; Koch Institute for Integrative Cancer Research.; Massachusetts Institute of Technology, Cambridge, MA, USA., Li AX; Koch Institute for Integrative Cancer Research.; Massachusetts Institute of Technology, Cambridge, MA, USA., Trojan SE; Koch Institute for Integrative Cancer Research.; Department of Biology.; Massachusetts Institute of Technology, Cambridge, MA, USA., Flower CT; Koch Institute for Integrative Cancer Research.; Center for Precision Cancer Medicine.; Program in Computational and Systems Biology.; Massachusetts Institute of Technology, Cambridge, MA, USA., Vo P; Dana-Farber Cancer Institute, Boston, MA, USA., Cui Y; Koch Institute for Integrative Cancer Research.; Department of Biological Engineering.; Massachusetts Institute of Technology, Cambridge, MA, USA., Davis JC; Koch Institute for Integrative Cancer Research.; Department of Biology.; Massachusetts Institute of Technology, Cambridge, MA, USA., Mukkamala RS; Koch Institute for Integrative Cancer Research.; Department of Biological Engineering.; Massachusetts Institute of Technology, Cambridge, MA, USA., Venditti FN; Koch Institute for Integrative Cancer Research.; Massachusetts Institute of Technology, Cambridge, MA, USA., Hillis AL; Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Toker A; Department of Pathology and Cancer Center, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA., Vander Heiden MG; Koch Institute for Integrative Cancer Research.; Center for Precision Cancer Medicine.; Department of Biology.; Massachusetts Institute of Technology, Cambridge, MA, USA.; Dana-Farber Cancer Institute, Boston, MA, USA., Spinelli JB; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Kennedy NJ; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., Davis RJ; Program in Molecular Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA., White FM; Koch Institute for Integrative Cancer Research.; Center for Precision Cancer Medicine.; Department of Biological Engineering.; Program in Computational and Systems Biology.; Massachusetts Institute of Technology, Cambridge, MA, USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Aug 29. Date of Electronic Publication: 2024 Aug 29.

High-Density, Targeted Monitoring of Tyrosine Phosphorylation Reveals Activated Signaling Networks in Human Tumors.

Autor: Stopfer LE; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.; Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts., Flower CT; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts.; Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.; Program in Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts., Gajadhar AS; Thermo Fisher Scientific, San Jose, California., Patel B; Thermo Fisher Scientific, Rockford, Illinois., Gallien S; Thermo Fisher Scientific, Precision Medicine Science Center, Cambridge, Massachusetts., Lopez-Ferrer D; Thermo Fisher Scientific, San Jose, California., White FM; Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts. fwhite@mit.edu.; Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts.; Program in Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts.

Publikováno v: Cancer research [Cancer Res] 2021 May 01; Vol. 81 (9), pp. 2495-2509. Date of Electronic Publication: 2021 Jan 28.

Light-regulated allosteric switch enables temporal and subcellular control of enzyme activity.

Autor: Shaaya M; Department of Pharmacology and Regenerative Medicine, The University of Illinois at Chicago, College of Medicine, Chicago, United States., Fauser J; Department of Pharmacology and Regenerative Medicine, The University of Illinois at Chicago, College of Medicine, Chicago, United States., Zhurikhina A; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, United States., Conage-Pough JE; The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, United States.; Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, United States.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, United States., Huyot V; Department of Pharmacology and Regenerative Medicine, The University of Illinois at Chicago, College of Medicine, Chicago, United States., Brennan M; Department of Pharmacology and Regenerative Medicine, The University of Illinois at Chicago, College of Medicine, Chicago, United States., Flower CT; The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, United States.; Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, United States.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, United States.; Program in Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, United States., Matsche J; Department of Pharmacology and Regenerative Medicine, The University of Illinois at Chicago, College of Medicine, Chicago, United States., Khan S; Department of Pharmacology and Regenerative Medicine, The University of Illinois at Chicago, College of Medicine, Chicago, United States., Natarajan V; Department of Pharmacology and Regenerative Medicine, The University of Illinois at Chicago, College of Medicine, Chicago, United States., Rehman J; Department of Pharmacology and Regenerative Medicine, The University of Illinois at Chicago, College of Medicine, Chicago, United States.; University of Illinois Cancer Center, The University of Illinois at Chicago, Chicago, United States.; Division of Cardiology, Department of Medicine, The University of Illinois, College of Medicine, Chicago, United States., Kota P; Marsico Lung Institute, Cystic Fibrosis Center and Department of Medicine, University of North Carolina, Chapel Hill, United States., White FM; The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, United States.; Center for Precision Cancer Medicine, Massachusetts Institute of Technology, Cambridge, United States.; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, United States.; Program in Computational and Systems Biology, Massachusetts Institute of Technology, Cambridge, United States., Tsygankov D; Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University School of Medicine, Atlanta, United States., Karginov AV; Department of Pharmacology and Regenerative Medicine, The University of Illinois at Chicago, College of Medicine, Chicago, United States.; University of Illinois Cancer Center, The University of Illinois at Chicago, Chicago, United States.

Publikováno v: ELife [Elife] 2020 Sep 23; Vol. 9. Date of Electronic Publication: 2020 Sep 23.