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B cell mediated immune response in chronic viral infection studied through immunoglobulin engineering

Autor: Florova, Marianna

Protective neutralizing antibodies against chronic viral pathogens arise late after the onset of the infection and are not trivial to elicit with immunization. Both in the polyclonal B cell repertoire and upon characterizing the newly generated neutr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ba17660339c841ba2e722d5581a673
https://edoc.unibas.ch/87422/

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Chronic Viral Infection Promotes Efficient Germinal Center B Cell Responses.

Autor: Fallet B; Department of Biomedicine, Division of Experimental Virology, University of Basel, Haus Petersplatz, 4009 Basel, Switzerland., Hao Y; Development of the Immune System, Institut Necker-Enfants Malades, Institut National de la Santé et de la Recherche Médicale, U1151-Centre National de la Recherche Scientifique, UMR 8253, Faculté de Médecine Paris Descartes, Université Paris Descartes, Sorbonne Paris Cité, Paris, France; Department of Pathogen Biology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China., Florova M; Department of Biomedicine, Division of Experimental Virology, University of Basel, Haus Petersplatz, 4009 Basel, Switzerland., Cornille K; Department of Biomedicine, Division of Experimental Virology, University of Basel, Haus Petersplatz, 4009 Basel, Switzerland., de Los Aires AV; Development of the Immune System, Institut Necker-Enfants Malades, Institut National de la Santé et de la Recherche Médicale, U1151-Centre National de la Recherche Scientifique, UMR 8253, Faculté de Médecine Paris Descartes, Université Paris Descartes, Sorbonne Paris Cité, Paris, France., Girelli Zubani G; Development of the Immune System, Institut Necker-Enfants Malades, Institut National de la Santé et de la Recherche Médicale, U1151-Centre National de la Recherche Scientifique, UMR 8253, Faculté de Médecine Paris Descartes, Université Paris Descartes, Sorbonne Paris Cité, Paris, France., Ertuna YI; Department of Biomedicine, Division of Experimental Virology, University of Basel, Haus Petersplatz, 4009 Basel, Switzerland., Greiff V; Department of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland; Department of Immunology, University of Oslo, Oslo, Norway., Menzel U; Department of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland., Hammad K; Department of Pathology and Immunology, Division of Clinical Pathology, University & University Hospital of Geneva, Geneva, Switzerland., Merkler D; Department of Pathology and Immunology, Division of Clinical Pathology, University & University Hospital of Geneva, Geneva, Switzerland., Reddy ST; Department of Biosystems Science and Engineering, ETH Zürich, Basel, Switzerland., Weill JC; Development of the Immune System, Institut Necker-Enfants Malades, Institut National de la Santé et de la Recherche Médicale, U1151-Centre National de la Recherche Scientifique, UMR 8253, Faculté de Médecine Paris Descartes, Université Paris Descartes, Sorbonne Paris Cité, Paris, France., Reynaud CA; Development of the Immune System, Institut Necker-Enfants Malades, Institut National de la Santé et de la Recherche Médicale, U1151-Centre National de la Recherche Scientifique, UMR 8253, Faculté de Médecine Paris Descartes, Université Paris Descartes, Sorbonne Paris Cité, Paris, France., Pinschewer DD; Department of Biomedicine, Division of Experimental Virology, University of Basel, Haus Petersplatz, 4009 Basel, Switzerland. Electronic address: daniel.pinschewer@unibas.ch.

Publikováno v: Cell reports [Cell Rep] 2020 Jan 28; Vol. 30 (4), pp. 1013-1026.e7.