Výsledky vyhledávání - "Floro Cataniag"

Production of Cytomegalovirus Dense Bodies by Scalable Bioprocess Methods Maintains Immunogenicity and Improves Neutralizing Antibody Titers

Autor: Nga Nguyen, Floro Cataniag, Michael P. McCarthy, Zhaoti Wang, Greg Duke, Stacie L. Lambert, Alivelu Irrinki, Yi Liu, A. Louise McCormick, Hui Liu, Kirsten Schneider-Ohrum, Shahin Aslam, Corinne Cayatte

Publikováno v: Journal of Virology. 90:10133-10144

With the goal of developing a virus-like particle-based vaccine based on dense bodies (DB) produced by human cytomegalovirus (HCMV) infections, we evaluated scalable culture, isolation, and inactivation methods and applied technically advanced assays

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f0858641844388a4a934def4d86a3b
https://doi.org/10.1128/jvi.00463-16

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Development of a robust, higher throughput green fluorescent protein (GFP)-based Epstein-Barr Virus (EBV) micro-neutralization assay

Autor: Jason D. Marshall, Rui Lin, Michael P. McCarthy, Vera Chio, Darren S. Heeke, Li Yu, Hui Liu, Eileen Rao, Fengrong Zuo, Floro Cataniag

Publikováno v: Journal of virological methods. 247

The goal of most prophylactic vaccines is to elicit robust and effective neutralizing antibodies against the human pathogen target. The titer of neutralizing antibodies to Epstein-Barr Virus (EBV) is a useful biomarker for evaluating EBV vaccines. He

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6cd21dbd7cfa4028062af1d2f711ab7
https://pubmed.ncbi.nlm.nih.gov/28457783

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Separation of adeno-associated virus type 2 empty particles from genome containing vectors by anion-exchange column chromatography

Autor: Pete Smith, Joseph Prado, Glenn F. Pierce, Floro Cataniag, Shangzhen Zhou, Katherine A. High, Alex Tai, Jac Luna, Jennifer Wellman McDonnell, J. Fraser Wright, Guang Qu, Jurg M. Sommer, Jingmin Zhou, Peter Colosi, Bernd Hauck, Jennifer Bahr-Davidson

Publikováno v: Journal of Virological Methods. 140:183-192

Adeno-associated virus (AAV) empty capsids typically co-purify with genome containing AAV2 vectors purified by column chromatography. This study describes a method to remove empty capsids from genome containing vector particles by anion exchange chro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b1d912561265ebd70ac0de886cf63f4
https://doi.org/10.1016/j.jviromet.2006.11.019

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424. Development of a Scalable Column Chromatography-Based Purification Process To Manufacure Empty Capsid-Free AAV Vectors

Autor: Guang Qu, Sooah Sohr, Floro Cataniag, Fraser Wright, Xiaofei Wang, Jac Luna

Publikováno v: Molecular Therapy. 9:S162

Recombinant adeno-associated virus (rAAV) has shown great promise as a DNA-based biopharmaceutical agent to treat serious human diseases. In conjunction with efforts in pre-clinical and clinical development, there is a significant need to develop and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c85d7f321dd733ffbef055493e47c703
https://doi.org/10.1016/j.ymthe.2004.06.346

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423. Isolation of an Adeno-Associated Virus (AAV)-Specific Camelid-Derived Single Chain Antibody Fragment: A Novel Tool for Purification of AAV Vectors of Different Serotypes

Autor: Xiaofei Wang, Sooah Sohr, Guang Qu, Fraser Wright, Floro Cataniag

Publikováno v: Molecular Therapy. 9:S162

The manufacture of recombinant AAV2 to support clinical studies has been carried out using transient transfection of HEK293 cells grown in roller bottles. While this method gives high productivity (50,000 vg/cell) relative to other methods of vector

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f4f1181f25e675c0ba1c3c7172bcba79
https://doi.org/10.1016/j.ymthe.2004.06.344

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