Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Floris P.J.T. Rutjes"'
Autor:
Floris L. van Delft, Floris P.J.T. Rutjes, Gerard W. Canters, Alessio Andreoni, Leandro C. Tabares, M. Waqar Aslam
Publikováno v:
Pharmaceuticals, Vol 3, Iss 3, Pp 679-701 (2010)
A small library of truncated neomycin-conjugates is prepared by consecutive removal of 2,6-diaminoglucose rings, oxidation-reductive amination of ribose, oxidation-conjugation of aminopyridine/aminoquinoline and finally dimerization. The dimeric conj
Externí odkaz:
https://doaj.org/article/4885a564170c4fa481e9d9cdccf86dc0
Autor:
Daniel Blanco-Ania, Carolina Valderas-Cortina, Pedro H.H. Hermkens, Leo A.J.M. Sliedregt, Hans W. Scheeren, Floris P.J.T. Rutjes
Publikováno v:
Molecules, Vol 15, Iss 4, Pp 2269-2301 (2010)
The synthesis of a small library of dihydrouracils spiro-fused to pyrrolidines is described. These compounds are synthesized from b-aryl pyrrolidines, providing products with the 2-arylethyl amine moiety, a structural feature often encountered in com
Externí odkaz:
https://doaj.org/article/c4a2a19d08354868a02861a5204428b3
Autor:
Susan Roosenburg, Peter Laverman, Lieke Joosten, Annemarie Eek, Floris P.J.T. Rutjes, Floris L. van Delft, Otto C. Boerman
Publikováno v:
Molecular Imaging, Vol 11 (2012)
Cholecystokinin (CCK) receptors are overexpressed in several human tumor types, such as medullary thyroid carcinomas and small cell lung cancers. Several ligands for the CCK2 receptor (CCK2R) have been developed for radionuclide targeting of these tu
Externí odkaz:
https://doaj.org/article/e893be429ff94600bd631e0fd8ad4ecd
Autor:
Richard H. Blaauw, Denis R. Ijzendoorn, Jozef G.O. Cremers, Floris P.J.T. Rutjes, Quirinus B. Broxterman, Hans E. Schoemaker
Publikováno v:
CHIMIA, Vol 58, Iss 3 (2004)
Two complementary strategies for the synthesis of optically active fluorine-containing building blocks have been probed. The first strategy involves either the enzymatic resolution of fluorinated ?,?-disubstituted-?-amino acid amides, or the asymmetr
Externí odkaz:
https://doaj.org/article/e61d5091e6c7430484feb21fa905a034
Autor:
Hans E. Schoemaker, Wilhelmus H.J. Boesten, Quirinus B. Broxterman, Eric C. Roos, Bernard Kaptein, Will J.J. van den Tweel, Johan Kamphuis, Emmo M. Meijer, Floris P.J.T. Rutjes
Publikováno v:
CHIMIA, Vol 51, Iss 6 (1997)
Aminopeptidase- and amidase-based methods for the production of enantiomerically pure amino acids, intermediates for pharmaceuticals and agrochemicals, are discussed. Furthermore, enzymatic syntheses of the dipeptide sweetener aspartame and semisynth
Externí odkaz:
https://doaj.org/article/c682ce31a4784b23a95dda9ab6badbe1
Autor:
Ron A. Wevers, Levinus A. Bok, Erik de Vrieze, Thomas J. Boltje, Laura A. Tseng, Saadet Mercimek-Andrews, Tessa M.A. Peters, Keith Hyland, Marleen C. D. G. Huigen, Giel Berden, Clara D.M. van Karnebeek, Hilal H. Al-Shekaili, Floris P.J.T. Rutjes, Arno van Rooij, Sidney M. Gospe, Fred A. M. G. van Geenen, Sanne Broekman, Jasmin Mecinović, Jona Merx, Eduard A. Struys, Michèl A.A.P. Willemsen, Jos Oomens, Erwin van Wijk, Leo A.J. Kluijtmans, Laura A. Jansen, Udo Engelke, Purva Kulkarni, Jonathan Martens, Blair R. Leavitt, Rianne E. van Outersterp, Karlien L.M. Coene
Publikováno v:
Journal of Clinical Investigation, 131(15):e148272. The American Society for Clinical Investigation
Engelke, U F H, van Outersterp, R E, Merx, J, van Geenen, F A M G, van Rooij, A, Berden, G, Huigen, M C D G, Kluijtmans, L A J, Peters, T M A, Al-Shekaili, H H, Leavitt, B R, de Vrieze, E, Broekman, S, van Wijk, E, Tseng, L A, Kulkarni, P, Rutjes, F P J T, Mecinović, J, Struys, E A, Jansen, L A, Gospe, S M, Mercimek-Andrews, S, Hyland, K, Willemsen, M A A P, Bok, L A, van Karnebeek, C D M, Wevers, R A, Boltje, T J, Oomens, J, Martens, J & Coene, K L M 2021, ' Untargeted metabolomics and infrared ion spectroscopy identify biomarkers for pyridoxine-dependent epilepsy ', Journal of Clinical Investigation, vol. 131, no. 15, e148272 . https://doi.org/10.1172/JCI148272
Journal of Clinical Investigation, 131
Engelke, U F, van Outersterp, R E, Merx, J, van Geenen, F A, van Rooij, A, Berden, G, Huigen, M C, Kluijtmans, L A, Peters, T M, Al-Shekaili, H H, Leavitt, B R, de Vrieze, E, Broekman, S, van Wijk, E, Tseng, L A, Kulkarni, P, Rutjes, F P, Mecinović, J, Struys, E A, Jansen, L A, Gospe, S M, Mercimek-Andrews, S, Hyland, K, Willemsen, M A, Bok, L A, Van Karnebeek, C D, Wevers, R A, Boltje, T J, Oomens, J, Martens, J & Coene, K L 2021, ' Untargeted metabolomics and infrared ion spectroscopy identify biomarkers for pyridoxine-dependent epilepsy ', Journal of Clinical Investigation, vol. 131, no. 15, e148272 . https://doi.org/10.1172/JCI148272
Journal of Clinical Investigation, 131, 15
J Clin Invest
Journal of clinical investigation, 131(15):e148272. The American Society for Clinical Investigation
Engelke, U F H, van Outersterp, R E, Merx, J, van Geenen, F A M G, van Rooij, A, Berden, G, Huigen, M C D G, Kluijtmans, L A J, Peters, T M A, Al-Shekaili, H H, Leavitt, B R, de Vrieze, E, Broekman, S, van Wijk, E, Tseng, L A, Kulkarni, P, Rutjes, F P J T, Mecinović, J, Struys, E A, Jansen, L A, Gospe, S M, Mercimek-Andrews, S, Hyland, K, Willemsen, M A A P, Bok, L A, van Karnebeek, C D M, Wevers, R A, Boltje, T J, Oomens, J, Martens, J & Coene, K L M 2021, ' Untargeted metabolomics and infrared ion spectroscopy identify biomarkers for pyridoxine-dependent epilepsy ', Journal of Clinical Investigation, vol. 131, no. 15, e148272 . https://doi.org/10.1172/JCI148272
Journal of Clinical Investigation, 131
Engelke, U F, van Outersterp, R E, Merx, J, van Geenen, F A, van Rooij, A, Berden, G, Huigen, M C, Kluijtmans, L A, Peters, T M, Al-Shekaili, H H, Leavitt, B R, de Vrieze, E, Broekman, S, van Wijk, E, Tseng, L A, Kulkarni, P, Rutjes, F P, Mecinović, J, Struys, E A, Jansen, L A, Gospe, S M, Mercimek-Andrews, S, Hyland, K, Willemsen, M A, Bok, L A, Van Karnebeek, C D, Wevers, R A, Boltje, T J, Oomens, J, Martens, J & Coene, K L 2021, ' Untargeted metabolomics and infrared ion spectroscopy identify biomarkers for pyridoxine-dependent epilepsy ', Journal of Clinical Investigation, vol. 131, no. 15, e148272 . https://doi.org/10.1172/JCI148272
Journal of Clinical Investigation, 131, 15
J Clin Invest
Journal of clinical investigation, 131(15):e148272. The American Society for Clinical Investigation
Contains fulltext : 237516.pdf (Publisher’s version ) (Open Access) BackgroundPyridoxine-dependent epilepsy (PDE-ALDH7A1) is an inborn error of lysine catabolism that presents with refractory epilepsy in newborns. Biallelic ALDH7A1 variants lead to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471fe467fa7a198066d44a682b4105e9
https://research.vumc.nl/en/publications/4a38f8f6-27d4-485c-ad8a-7e7e0fa52902
https://research.vumc.nl/en/publications/4a38f8f6-27d4-485c-ad8a-7e7e0fa52902
Autor:
Lieke Joosten, Peter Laverman, Floris L. van Delft, Floris P.J.T. Rutjes, Annemarie Eek, Susan Roosenburg, Otto C. Boerman
Publikováno v:
Molecular Imaging, 11, 5, pp. 401-407
Molecular Imaging, 11, 401-407
Molecular Imaging, 11, 401-407
Contains fulltext : 103436.pdf (Publisher’s version ) (Open Access) Cholecystokinin (CCK) receptors are overexpressed in several human tumor types, such as medullary thyroid carcinomas and small cell lung cancers. Several ligands for the CCK2 recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6491e7ecb7f6e71af3e83c72e783d54d
https://hdl.handle.net/2066/103436
https://hdl.handle.net/2066/103436