Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Floris P. Buelens"'
Publikováno v:
Journal of Chemical Theory and Computation
In the numerous molecular recognition and catalytic processes across biochemistry involving adenosine triphosphate (ATP), the common bioactive form is its magnesium chelate, ATP·Mg2+. In aqueous solution, two chelation geometries predominate, distin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21607aa838b262654ec8c318b60836d0
https://hdl.handle.net/21.11116/0000-0008-5119-121.11116/0000-0008-511C-E
https://hdl.handle.net/21.11116/0000-0008-5119-121.11116/0000-0008-511C-E
Publikováno v:
Biophysical Journal. 120:178a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::920d1328c9213c9513bb84051bbcfa23
https://doi.org/10.1016/j.bpj.2020.11.1247
https://doi.org/10.1016/j.bpj.2020.11.1247
Autor:
Martin Grininger, Melanie Janßen, Sascha Serdjukow, Helmut Grubmüller, Jan Gajewski, Niña Socorro Cortina, Floris P. Buelens
Publikováno v:
Nature Chemical Biology
In this study, we engineered fatty acid synthases (FAS) for the biosynthesis of short-chain fatty acids and polyketides, guided by a combined in vitro and in silico approach. Along with exploring the synthetic capability of FAS, we aim to build a fou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::199867d4f6893207b68f7dcbee09dd63
https://doi.org/10.1038/nchembio.2314
https://doi.org/10.1038/nchembio.2314
Publikováno v:
Biophysical Journal. 118:143a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6fcbbe502021e7fb5b320e2156243c28
https://doi.org/10.1016/j.bpj.2019.11.905
https://doi.org/10.1016/j.bpj.2019.11.905
Autor:
Floris P. Buelens, Helmut Grubmüller
Publikováno v:
Biophysical Journal. 110(3)
The multienzyme fatty acid synthase (FAS) system represents a metabolic cornerstone in all domains of cellular life and has been the subject of biochemical study for over five decades. Recently there has been an upswing of interest in fatty acid synt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21758420df09b4b79f30deec1af9afe6
Publikováno v:
Nucleic Acids Research
DNA-binding proteins are key players in the regula- tion of gene expression and, hence, are essential for cell function. Chimeric proteins composed of DNA- binding domains and DNA modifying domains allow for precise genome manipulation. A key prerequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ffca9e00a6b8ea80a565ebf26998743
https://doi.org/10.1093/nar/gkr531
https://doi.org/10.1093/nar/gkr531
Publikováno v:
Biophysical Journal. 114:680a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21c5342da0e9463b8f654e32c9f32324
https://doi.org/10.1016/j.bpj.2017.11.3668
https://doi.org/10.1016/j.bpj.2017.11.3668
Publikováno v:
Biophysical Journal. 104(2)
Long-chain fatty acids form the membranes of every living cell and are an important component of energy storage and metabolism for higher organisms. Biosynthesis of fatty acids occurs over multiple iterations of a cycle of seven successively repeated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2bfb32a59125a2d540fc8b487df33ba8
Autor:
Floris P. Buelens, Helmut Grubmüller
Publikováno v:
Journal of Computational Chemistry
Alchemical free energy calculations hold the promise of unrivalled quantitative accuracy in the computational study of molecular recognition and related biochemical processes. Although noteworthy successes have been reported, there remains significan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::290fdfc879484e13490717542eb1dba1
https://hdl.handle.net/11858/00-001M-0000-000F-0086-411858/00-001M-0000-0027-C6EE-2
https://hdl.handle.net/11858/00-001M-0000-000F-0086-411858/00-001M-0000-0027-C6EE-2
Autor:
Julia C. A. More, Ann Marie L. Ogden, David E. Jane, Vernon R. J. Clarke, Zuner A. Bortolotto, Nigel P. Dolman, Fabio Pilato, Robert Nisticò, Andrew Alt, David Bleakman, Floris P. Buelens, Graham L. Collingridge, Helen M Troop, Eve E. Kelland
Willardiine derivatives with an N3-benzyl substituent bearing an acidic group have been synthesized with the aim of producing selective antagonists for GLUK5-containing kainate receptors. UBP296 was found to be a potent and selective antagonist of na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa3f707d8a6a5ef58f76157c818b83e0
http://hdl.handle.net/11573/514325
http://hdl.handle.net/11573/514325