Intradermal lipopolysaccharide challenge as an acute in vivo inflammatory model in healthy volunteers

Autor: Wouter ten Voorde, Robert Rissmann, Michelle Osse, Manon A. A. Jansen, G. Feiss, Edwin Florencia, Mascha Schoonakker, Floris C. van Hindevoort, Matthijs Moerland, Erik Lubberts, Pieter W Hameeteman, Thomas P. Buters, Jeffrey Damman, Amit Patel, Iris M. E. Jansen, Marieke L. de Kam, Jacobus Burggraaf, Simon Yona, Derek W. Gilroy, Hendrika W. Grievink

Publikováno v: British Journal of Clinical Pharmacology, 88(2), 680-690. Wiley-Blackwell Publishing Ltd
British Journal of Clinical Pharmacology, 88(2), 680-690. WILEY

Aims: Whereas intravenous administration of Toll-like receptor 4 ligand lipopolysaccharide (LPS) to human volunteers is frequently used in clinical pharmacology studies, systemic use of LPS has practical limitations. We aimed to characterize the intr

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