Plasticity of the binding pocket in peptide transporters underpins promiscuous substrate recognition

Autor: Vadim Kotov, Maxime Killer, Katharina E.J. Jungnickel, Jian Lei, Giada Finocchio, Josi Steinke, Kim Bartels, Jan Strauss, Florine Dupeux, Anne-Sophie Humm, Irina Cornaciu, José A. Márquez, Els Pardon, Jan Steyaert, Christian Löw

Publikováno v: Cell Reports, Vol 42, Iss 8, Pp 112831- (2023)

Summary: Proton-dependent oligopeptide transporters (POTs) are promiscuous transporters of the major facilitator superfamily that constitute the main route of entry for a wide range of dietary peptides and orally administrated peptidomimetic drugs. G

Externí odkaz: https://doaj.org/article/fd27d33b5518420ebb2f497a27ffb4e6

An automated platform for structural analysis of membrane proteins through serial crystallography

Autor: José A. Márquez, Sébastien Granier, Jérôme Golebiowski, Cedric Leyrat, Shibom Basu, Xiaojing Cong, Robert D. Healey, Anne-Sophie Humm, Andrea Pica, Florine Dupeux

Publikováno v: Cell reports / Methods 1(6), 100102 (2021). doi:10.1016/j.crmeth.2021.100102
bioRxiv
Cell Reports Methods
Cell Reports Methods, 2021, 1 (6), pp.100102. ⟨10.1016/j.crmeth.2021.100102⟩
'Cell Reports Methods ', vol: 1, pages: 100102-1-100102-12 (2021)
Cell Reports Methods, Cell Press Elsevier, 2021, 1 (6), ⟨10.1016/j.crmeth.2021.100102⟩

Summary Membrane proteins are central to many pathophysiological processes, yet remain very difficult to analyze structurally. Moreover, high-throughput structure-based drug discovery has not yet been exploited for membrane proteins because of lack o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87990525340cacac5f3d207032fbf914

Modulation of Abscisic Acid Signaling in Vivo by an Engineered Receptor-Insensitive Protein Phosphatase Type 2C Allele

Autor: Pedro L. Rodriguez, José A. Márquez, Katja Betz, Sean R. Cutler, Sang-Youl Park, Regina Antoni, Miguel González-Guzmán, Julia Santiago, Silvia Rubio, Florine Dupeux, Lesia Rodriguez

Publikováno v: Plant Physiology. 156:106-116

The plant hormone abscisic acid (ABA) plays a crucial role in the control of the stress response and the regulation of plant growth and development. ABA binding to PYRABACTIN RESISTANCE1 (PYR1)/PYR1-LIKE (PYL)/REGULATORY COMPONENTS OF ABA RECEPTORS i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8beff6b5707528a3e6c87d0fa0d32d08
https://doi.org/10.1104/pp.110.170894

The abscisic acid receptor PYR1 in complex with abscisic acid

Autor: Sean R. Cutler, Pedro L. Rodriguez, Marc Jamin, Sang-Youl Park, Florine Dupeux, José A. Márquez, Julia Santiago, Regina Antoni, Adam Round

Publikováno v: Nature. 462:665-668

The plant hormone abscisic acid (ABA) has a central role in coordinating the adaptive response in situations of decreased water availability as well as the regulation of plant growth and development. Recently, a 14-member family of intracellular ABA

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18938999a561ae703b194cb28ecfd202
https://doi.org/10.1038/nature08591

Live-Cell Imaging Reveals a Stable Cohesin-Chromatin Interaction after but Not before DNA Replication

Autor: Birgit Koch, Jan-Michael Peters, Florine Dupeux, Jan Ellenberg, Daniel W. Gerlich

Publikováno v: Current Biology. 16(15):1571-1578

SummaryCohesin is a multisubunit protein complex that links sister chromatids from replication until segregation [1, 2]. The lack of obvious cohesin-targeting-specific sequences on DNA [3–5], as well as cohesin's molecular arrangement as a large ri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcf3c5d35e13c8a0aad6d57d611c8fa0