Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Florina Grigore"'
Autor:
Florina Grigore, Hana Yang, Nicholas D. Hanson, Matthew W. VanBrocklin, Aaron L. Sarver, James P. Robinson
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 22, Iss 9, Pp 376-389 (2020)
The development of mutant BRAF inhibitors has improved the outcome for melanoma patients with BRAFV600E mutations. Although the initial response to these inhibitors can be dramatic, sometimes resulting in complete tumor regression, the majority of me
Externí odkaz:
https://doaj.org/article/d80ae3ffcea34140aa80065f5fa10623
Publikováno v:
Romanian Neurosurgery, Vol 29, Iss 1 (2015)
GBM (Glioblastoma) is the most common, malignant type of primary brain tumor. It has a dismal prognosis, with an average life expectancy of less than 15 months. A better understanding of the tumor biology of GBM has been achieved in the past decade a
Externí odkaz:
https://doaj.org/article/9021e1f3e2324c9cb741bb9b2cd3178d
Autor:
Charles Day, Florina Grigore, Alyssa Langfald, Faruck Hakkim, David Daniels, Kevin Vaughan, James Robinson, Edward Hincliffe
Publikováno v:
Neuro-Oncology. 24:vii37-vii38
Diffuse midline gliomas (DMG) are high-grade pediatric gliomas that frequently harbor heterozygous histone H3.3 K27M, G34R, or G34V mutations. These mutations alter histone methylations, although the precise mechanism(s) of gliomagenesis remains unce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05d821ade51e299fd7e235b86b86b9a6
https://doi.org/10.1093/neuonc/noac209.147
https://doi.org/10.1093/neuonc/noac209.147
Autor:
Charles A. Day, Florina Grigore, Faruck L. Hakkim, Alyssa Langfald, Sela Fadness, Paiton Schwab, Leslie Sepaniac, Jason Stumpff, David J. Daniels, Kevin T. Vaughan, James P. Robinson, Edward H. Hinchcliffe
During the cell cycle, differential phosphorylation of select histone H3 serine/threonine residues regulates chromatin structure, necessary for both dynamic transcriptional control and proper chromosome segregation1-2. Histone H3.3 contains a highly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9f3eecf7575dbd2d6284e2314625548
https://doi.org/10.1101/2022.05.27.493485
https://doi.org/10.1101/2022.05.27.493485
Autor:
Clark C. Chen, Noah V. Gavil, Jianfang Ning, Shaoping Wu, Florina Grigore, David Masopust, Sanjay Dhawan, Ming Li, Pamela C. Rosato, Jun Ma
Publikováno v:
Neuro Oncol
Immunotherapy with the success of checkpoint blockade brings hope for cancer treatment with enduring or complete responses in various types of advanced malignancies, however, it has not benefited a number of so called “cold tumors”, such as gliob
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2ed9630e7aa903b07c0e293a88eff6c
https://europepmc.org/articles/PMC8598851/
https://europepmc.org/articles/PMC8598851/
Publikováno v:
Neuro Oncol
H3.3 G34R/V mutations are drivers of high-grade pediatric glioma (pHGG). H3.3 G34R/V mutations are linked to altered H3.3 K36 trimethylation (H3K36me3); implicating epigenetic gene regulation as a possible contributor to pHGG formation. Here we show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36288198c4d18a04d0454b8ca90280cc
https://europepmc.org/articles/PMC8598742/
https://europepmc.org/articles/PMC8598742/
Autor:
Faruck Hakkim, Charles Day, Florina Grigore, Alyssa Langfald, Igor Entin, Edward Hincliffe, James Robinson
Publikováno v:
Neuro-Oncology. 24:vii42-vii42
Diffuse midline gliomas (DMG) are aggressive high-grade gliomas that characteristically occurs in children. Heterozygous K27M mutation occurs in histone H3.3 as early events in DMG and are sufficient to drive a global reduction of H3K27 methylation (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dab49fca4082a4408dbdcf998d240359
https://doi.org/10.1093/neuonc/noac209.164
https://doi.org/10.1093/neuonc/noac209.164
Publikováno v:
International Journal of Oncology. 59
Glioblastoma multiforme (GBM) is a primary brain tumor with a high mortality rate and a median survival time of ~14 months from the initial diagnosis. Although progress has been made in the currently available therapies, the treatment of GBM remains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ff04f809a6a78278ed164a8272b50f0
https://doi.org/10.3892/ijo.2021.5225
https://doi.org/10.3892/ijo.2021.5225
Autor:
Charles Day, Florina Grigore, Alyssa Langfald, David J. Daniels, James Robinson, Edward Hinchcliffe
Publikováno v:
Cancer Research. 82:705-705
The heterozygous H3.3 K27M mutation is found in the majority of pediatric High-Grade Glioma’s (pHGG). H3.3 K27M is thought to promote tumor formation through altered epigenetic gene regulation. However, it is unclear if epigenetic reprogramming alo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2d1878692243d998decdade5799fe8b
https://doi.org/10.1158/1538-7445.am2022-705
https://doi.org/10.1158/1538-7445.am2022-705
Autor:
Charles Day, Florina Grigore, Faruck Hakkim, Alyssa Langfald, Edward Hinchcliffe, James Robinson
Publikováno v:
Neuro-Oncology. 24:i67-i67
Pediatric high-grade gliomas (pHGG) are among the most lethal of all human cancers. Histone H3.3 G34R/V mutations are an early event in these tumors and show reduced H3.3 K36 trimethylation; implicating epigenetic dysregulation in tumorigenesis. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64e87f9102ac92392ed660004d4760fd
https://doi.org/10.1093/neuonc/noac079.245
https://doi.org/10.1093/neuonc/noac079.245