Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Floriane Gibault"'
Autor:
Ajaybabu V. Pobbati, Martine Pugnière, Ashley Burtscher, Patricia Melnyk, Fabrice Bailly, Brian P. Rubin, Frédéric Allemand, Manon Sturbaut, Philippe Cotelle, Jean-François Guichou, Floriane Gibault, Wanjin Hong, Mathilde Coevoet
Publikováno v:
ChemMedChem. 16:2823-2844
Starting from our previously reported hit, a series of 1,5-diaryl-1,2,3-triazole-4-carbohydrazones were synthesized and evaluated as inhibitors of the YAP/TAZ-TEAD complex. Their binding to hTEAD2 was confirmed by nanodifferential scanning fluorimetr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f90314b0aef66c0be324ac95b890b3be
https://doi.org/10.1002/cmdc.202100153
https://doi.org/10.1002/cmdc.202100153
Publikováno v:
Journal of Medicinal Chemistry. 61:5057-5072
Transcriptional enhanced associate domain (TEAD) proteins are the downstream effectors of the Hippo signaling pathway that regulate cell proliferation and stem cell functions. TEADs are unable to activate transcription and require the help of coactiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9564609c37885856d272fe8562928586
https://doi.org/10.1021/acs.jmedchem.7b00879
https://doi.org/10.1021/acs.jmedchem.7b00879
Autor:
Cotelle, Floriane Gibault, Mathilde Coevoet, Manon Sturbaut, Amaury Farce, Nicolas Renault, Frédéric Allemand, Jean-François Guichou, Anne-Sophie Drucbert, Catherine Foulon, Romain Magnez, Xavier Thuru, Matthieu Corvaisier, Guillemette Huet, Philippe Chavatte, Patricia Melnyk, Fabrice Bailly, Philippe
Publikováno v:
Cancers; Volume 10; Issue 5; Pages: 140
Intrinsically disordered protein YAP (yes-associated protein) interacts with TEADs transcriptional factors family (transcriptional enhancer associated domain) creating three interfaces. Interface 3, between the Ω-loop of YAP and a shallow pocket of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=multidiscipl::13606b9c6a06351fc8ff83f34bf19308
Autor:
Floriane Gibault, Patricia Melnyk, Matthieu Corvaisier, Fabrice Bailly, Philippe Cotelle, Mathilde Coevoet, Guillemette Huet
Publikováno v:
ChemMedChem
ChemMedChem, 2017, 52nd International Conference on Medicinal Chemistry, 12 (12), pp.954-961. ⟨10.1002/cmdc.201700063⟩
ChemMedChem, Wiley-VCH Verlag, 2017, 52nd International Conference on Medicinal Chemistry, 12 (12), pp.954-961. ⟨10.1002/cmdc.201700063⟩
ChemMedChem, 2017, 52nd International Conference on Medicinal Chemistry, 12 (12), pp.954-961. ⟨10.1002/cmdc.201700063⟩
ChemMedChem, Wiley-VCH Verlag, 2017, 52nd International Conference on Medicinal Chemistry, 12 (12), pp.954-961. ⟨10.1002/cmdc.201700063⟩
International audience; Porphyrin derivatives, in particular verteporfin (VP), a photosensitizer initially designed for cancer therapy, have been identified as inhibitors of the YAP–TEAD interaction and transcriptional activity. Herein we report th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::01c79c5dab67d0349c70de35e8db0f95
https://hal.archives-ouvertes.fr/hal-02060557
https://hal.archives-ouvertes.fr/hal-02060557
Autor:
Floriane Gibault, Matthieu Corvaisier, Patricia Melnyk, Guillemette Huet, Philippe Cotelle, Fabrice Bailly
Publikováno v:
Current Medicinal Chemistry
Current Medicinal Chemistry, Bentham Science Publishers, 2016
Current Medicinal Chemistry, 2016
Current Medicinal Chemistry, Bentham Science Publishers, 2016
Current Medicinal Chemistry, 2016
Background: Verteporfin is a porphyrinic photosensitizer clinically used for the photodynamic treatment of age-related macular degeneration. It has been identified almost simultaneously as a YAP/TEAD and an autophagosome inhibitor. Over the last few
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5f6721dd47fbeb74419f282257a5d67
https://hal.archives-ouvertes.fr/hal-02060761
https://hal.archives-ouvertes.fr/hal-02060761
Autor:
Emmanuelle Limanton, Christophe Brigaudeau, Laurence Agouridas, Alain Plenevaux, Raphaël Frédérick, Stéphane Bach, Nicolas Renault, Jose-Manuel Gally, Eric Goffin, Arnaud Caclard, Sebastien Dilly, Arina Kozlova, Jonathan Elie, Nicolas J. P. van Ham, Johan Wouters, Franck Suzenet, Ahmed El Hakmaoui, Floriane Gibault, Mattieu Place, Laurent Meijer, Lionel Pochet, Muriel Pipelier, Pierre Francotte, Jean Pierre Bazureau, Abdelaziz Ejjoummany, Guillemette Huet, Denis Guilloteau, Sandrine Ruchaud, Bernard Pirotte, Tania Tahtouh, Gerard Boyer, Saïd Yous, Pascal Bouyssou, Patricia Melnyk, Aurelien Stutzmann, Pierre Geubelle, Matthieu Corvaisier, Philippe Cotelle, Thomas Dal Maso, Anne Corlu, Samia Aci-Seche, Christelle Ambeu, Mohamed Akssira, Karen Ple, Fabrice Bailly, Janat Akhanovna Mamyrbekova-Bekro, Alan Obled, Rudy Bidault, Sebastien Marx, Yves-Alain Bekro, Guillaume Burgy, Carine Michiels, Sandrine Piguel, Pierre-Louis Brun, Julien Hanson, Anoubile Benie, François Carreaux, Joseph d'Attoma, Emilie Durieu, Fabienne Neulat-Ripoll, Yves Robin, Olivier Mignen, Charlotte Bouckaert, Pascal Bonnet, Marine Schnetterle, Jette Sandholm Kastrup, Jean-Michel Bolla, Solène Guihéneuf, Stephane Bostyn, Chloe Copin, Julien R. C. Prevost, Camille Deliko Dago, Nicolas Arlicot, Wacothon Karime Coulibaly, Thomas Drapier, Anthony Champire, Johnny Vercouille, Luísa V. Lopes, Sandrine Alibert, Gerald Guillaumet, Romain Duroux, Jean-Thomas Heinrich, Frederic Buron, Rémy Le Guével, Fabrice Biot, Laurent Robin, Sylvain Routier, Cerine Michiels, Jean-Marie Pages, Janat Mamyrbekova-Berkro, Eric Valade, Ludovic Paquin
Publikováno v:
Pharmaceuticals
Pharmaceuticals, Vol 9, Iss 4, p 73 (2016)
Pharmaceuticals, Vol 9, Iss 4, p 73 (2016)
The “Journées Franco-Belges de Pharmacochimie” is a recognized annual meeting in organic and medicinal chemistry known for the quality of scientific exchange and conviviality. Young researchers were encouraged to present their work and share ide
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::375e8579b51b5c82be3ca9e504cf67af
https://doi.org/10.3390/ph9040073
https://doi.org/10.3390/ph9040073