ATP12A Proton Pump as an Emerging Therapeutic Target in Cystic Fibrosis and Other Respiratory Diseases

Autor: Michał Dębczyński, Giulia Gorrieri, Damian Mojsak, Floriana Guida, Federico Zara, Paolo Scudieri

Publikováno v: Biomolecules, Vol 13, Iss 10, p 1455 (2023)

ATP12A encodes the catalytic subunit of the non-gastric proton pump, which is expressed in many epithelial tissues and mediates the secretion of protons in exchange for potassium ions. In the airways, ATP12A-dependent proton secretion contributes to

Externí odkaz: https://doaj.org/article/e4fcc17ca85043fe808d9e56609ff549

TFEB Regulates ATP7B Expression to Promote Platinum Chemoresistance in Human Ovarian Cancer Cells

Autor: Raffaella Petruzzelli, Marta Mariniello, Rossella De Cegli, Federico Catalano, Floriana Guida, Elia Di Schiavi, Roman S. Polishchuk

Publikováno v: Cells
Cells; Volume 11; Issue 2; Pages: 219
Cells, Vol 11, Iss 219, p 219 (2022)
Cells 11 (2022). doi:10.3390/cells11020219
info:cnr-pdr/source/autori:Petruzzelli, Raffaella; Mariniello, Marta; De Cegli, Rossella; Catalano, Federico; Guida, Floriana; Di Schiavi, Elia; Polishchuk, Roman S./titolo:TFEB Regulates ATP7B Expression to Promote Platinum Chemoresistance in Human Ovarian Cancer Cells/doi:10.3390%2Fcells11020219/rivista:Cells/anno:2022/pagina_da:/pagina_a:/intervallo_pagine:/volume:11

ATP7B is a hepato-specific Golgi-located ATPase, which plays a key role in the regulation of copper (Cu) homeostasis and signaling. In response to elevated Cu levels, ATP7B traffics from the Golgi to endo-lysosomal structures, where it sequesters exc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cce9f31dfee1162b866b5a349e45087d
https://pubmed.ncbi.nlm.nih.gov/35053335