Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Florian Wimmers"'
Autor:
Audrey Lee, Madeleine K. D. Scott, Florian Wimmers, Prabhu S. Arunachalam, Wei Luo, Christopher B. Fox, Mark Tomai, Purvesh Khatri, Bali Pulendran
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Adjuvants provide additional impetus for the immune response to vaccination regimens, however their modes of activity and impact on particular compartments of the immune response are currently not well understood. Here the authors perform high resolu
Externí odkaz:
https://doaj.org/article/c4581bcc26564fe192f49148678f0969
Autor:
Florian Wimmers, Nikita Subedi, Nicole van Buuringen, Daan Heister, Judith Vivié, Inge Beeren-Reinieren, Rob Woestenenk, Harry Dolstra, Aigars Piruska, Joannes F. M. Jacobs, Alexander van Oudenaarden, Carl G. Figdor, Wilhelm T. S. Huck, I. Jolanda M. de Vries, Jurjen Tel
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Plasmacytoid dendritic cells (pDC) are a pivotal component of the immune system. Here, the authors utilize single-cell microfluidics to interrogate the human pDC compartment and reveal a subset of type I IFN secreting pDCs that is regulated by stocha
Externí odkaz:
https://doaj.org/article/5014ff7f8a254b8ab188443ef63dba4a
Autor:
Prabhu S. Arunachalam, Madeleine K. D. Scott, Thomas Hagan, Chunfeng Li, Yupeng Feng, Florian Wimmers, Lilit Grigoryan, Meera Trisal, Venkata Viswanadh Edara, Lilin Lai, Sarah Esther Chang, Allan Feng, Shaurya Dhingra, Mihir Shah, Alexandra S. Lee, Sharon Chinthrajah, Sayantani B. Sindher, Vamsee Mallajosyula, Fei Gao, Natalia Sigal, Sangeeta Kowli, Sheena Gupta, Kathryn Pellegrini, Gregory Tharp, Sofia Maysel-Auslender, Sydney Hamilton, Hadj Aoued, Kevin Hrusovsky, Mark Roskey, Steven E. Bosinger, Holden T. Maecker, Scott D. Boyd, Mark M. Davis, Paul J. Utz, Mehul S. Suthar, Purvesh Khatri, Kari C. Nadeau, Bali Pulendran
Publikováno v:
Nature.
Autor:
I. Jolanda M. de Vries, Carl G. Figdor, Cornelis J.A. Punt, Winald R. Gerritsen, Christian U. Blank, Sander Kelderman, Joannes F.M. Jacobs, Rutger H.T. Koornstra, Sandra A.J. Croockewit, Roel D.M. Mus, Marieke E.B. Welzen, Michelle M. van Rossum, Willeke A.M. Blokx, Katja Petry, Gregor Winkels, Jurjen Tel, Tom G.M. van Oorschot, Michel A.M. Olde Nordkamp, Jeanette M. Pots, Annemiek J. de Boer, Nicole M. Scharenborg, Mandy W.M.M. van de Rakt, Tjitske Duiveman-de Boer, Erik H.J.G. Aarntzen, Florian Wimmers, Harm Westdorp, Kalijn F. Bol, Gerty Schreibelt
Supplementary Figure 3. KLH-specific immune responses before and after DC vaccination. (A) KLH-specific T cell proliferation was analyzed before the first vaccination and after each DC vaccination during the first vaccination cycle in peripheral bloo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ce748475936725a8bb47b16d85c4c40
https://doi.org/10.1158/1078-0432.22457933.v1
https://doi.org/10.1158/1078-0432.22457933.v1
Autor:
I. Jolanda M. de Vries, Carl G. Figdor, Cornelis J.A. Punt, Winald R. Gerritsen, Christian U. Blank, Sander Kelderman, Joannes F.M. Jacobs, Rutger H.T. Koornstra, Sandra A.J. Croockewit, Roel D.M. Mus, Marieke E.B. Welzen, Michelle M. van Rossum, Willeke A.M. Blokx, Katja Petry, Gregor Winkels, Jurjen Tel, Tom G.M. van Oorschot, Michel A.M. Olde Nordkamp, Jeanette M. Pots, Annemiek J. de Boer, Nicole M. Scharenborg, Mandy W.M.M. van de Rakt, Tjitske Duiveman-de Boer, Erik H.J.G. Aarntzen, Florian Wimmers, Harm Westdorp, Kalijn F. Bol, Gerty Schreibelt
Purpose: Thus far, dendritic cell (DC)-based immunotherapy of cancer was primarily based on in vitro–generated monocyte-derived DCs, which require extensive in vitro manipulation. Here, we report on a clinical study exploiting primary CD1c+ myeloid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::492a00959142946a6e6448b4074be089
https://doi.org/10.1158/1078-0432.c.6523763.v1
https://doi.org/10.1158/1078-0432.c.6523763.v1
Autor:
I. Jolanda M. de Vries, Carl G. Figdor, Cornelis J.A. Punt, Winald R. Gerritsen, Christian U. Blank, Sander Kelderman, Joannes F.M. Jacobs, Rutger H.T. Koornstra, Sandra A.J. Croockewit, Roel D.M. Mus, Marieke E.B. Welzen, Michelle M. van Rossum, Willeke A.M. Blokx, Katja Petry, Gregor Winkels, Jurjen Tel, Tom G.M. van Oorschot, Michel A.M. Olde Nordkamp, Jeanette M. Pots, Annemiek J. de Boer, Nicole M. Scharenborg, Mandy W.M.M. van de Rakt, Tjitske Duiveman-de Boer, Erik H.J.G. Aarntzen, Florian Wimmers, Harm Westdorp, Kalijn F. Bol, Gerty Schreibelt
Supplementary Figure 1. Schematic overview of the 44 h mDC vaccine preparation cycle and vaccination strategy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d06d6192c935b44e17609dce62fe016
https://doi.org/10.1158/1078-0432.22457939
https://doi.org/10.1158/1078-0432.22457939
Autor:
Florian Wimmers, Allison R. Burrell, Yupeng Feng, Hong Zheng, Prabhu S. Arunachalam, Mengyun Hu, Sara Spranger, Lindsay Nyhoff, Devyani Joshi, Meera Trisal, Mayanka Awasthi, Lorenza Bellusci, Usama Ashraf, Sangeeta Kowli, Katherine C. Konvinse, Emily Yang, Michael Blanco, Kathryn Pellegrini, Gregory Tharp, Thomas Hagan, R. Sharon Chinthrajah, Alba Grifoni, Alessandro Sette, Kari C. Nadeau, David B. Haslam, Steven E. Bosinger, Jens Wrammert, Holden T. Maecker, Paul J. Utz, Taia T. Wang, Surender Khurana, Purvesh Khatri, Mary A. Staat, Bali Pulendran
The dynamics of innate and adaptive immunity to infection in infants remain obscure. Here, we used a multi-omics approach to perform a longitudinal analysis of immunity to SARS-CoV-2 infection in infants and young children in the first weeks and mont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a51198e187371a54c8cfaf7667c4de61
https://doi.org/10.1101/2023.01.28.23285133
https://doi.org/10.1101/2023.01.28.23285133
Development of effective vaccines is a critical global health priority. Stimulating antigen-specific B and T cells to elicit long-lasting protection remains the central paradigm of vaccinology. Adjuvants are components that enhance vaccine immunogeni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b66d931adc062d976ea0175df4f0d513
Autor:
Meera Trisal, Prabhu S. Arunachalam, Bali Pulendran, Thomas Hagan, Allan Feng, Lilit Grigoryan, Natalia Sigal, Sheena Gupta, Kathryn L. Pellegrini, Mark Roskey, Kari C. Nadeau, Sarah Esther Chang, Steven E. Bosinger, Mehul S. Suthar, Sharon Chinthrajah, Venkata Viswanadh Edara, Mihir Shah, Mark M. Davis, Vamsee Mallajosyula, Fei Gao, Sayantani B. Sindher, Florian Wimmers, Yupeng Feng, Scott D. Boyd, Alexandra S. Lee, Holden T. Maecker, Sydney Hamilton, Chunfeng Li, Madeleine K D Scott, Lilin Lai, Purvesh Khatri, Sofia Maysel-Auslender, Shaurya Dhingra, Hadj Aoued, Paul J. Utz, Sangeeta Kowli, Gregory K. Tharp, Kevin Hrusovsky
Publikováno v:
Nature. 596:410-416
The emergency use authorization of two mRNA vaccines in less than a year from the emergence of SARS-CoV-2 represents a landmark in vaccinology1,2. Yet, how mRNA vaccines stimulate the immune system to elicit protective immune responses is unknown. He
Autor:
Wei Luo, Julia Z. Adamska, Chunfeng Li, Rohit Verma, Qing Liu, Thomas Hagan, Florian Wimmers, Shakti Gupta, Yupeng Feng, Wenxia Jiang, Jiehao Zhou, Erika Valore, Yanli Wang, Meera Trisal, Shankar Subramaniam, Timothy F. Osborne, Bali Pulendran
Publikováno v:
Nature immunology.
Our previous study using systems vaccinology identified an association between the sterol regulatory binding protein (SREBP) pathway and humoral immune response to vaccination in humans. To investigate the role of SREBP signaling in modulating immune