Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Florian Paasch"'
Publikováno v:
The Journal of Biological Chemistry
Journal of Biological Chemistry
Journal of Biological Chemistry
Modification by the ubiquitin-like protein SUMO affects hundreds of cellular substrate proteins and regulates a wide variety of physiological processes. While the SUMO system appears to predominantly target nuclear proteins and, to a lesser extent, c
Autor:
Birgit Fehrenbacher, Kirsten Lauber, Martin Schaller, David G. Campbell, Sebastian Alers, Alexandra M. Dieterle, Björn Stork, Sebastian Wesselborg, Florian Paasch, Hildegard Keppeler, Antje S. Löffler
Publikováno v:
Autophagy. 7(12)
Under normal growth conditions the mammalian target of rapamycin complex 1 (mTORC1) negatively regulates the central autophagy regulator complex consisting of Unc-51-like kinases 1/2 (Ulk1/2), focal adhesion kinase family-interacting protein of 200 k
Autor:
Thomas Iftner, Florian Paasch, Joachim Manns, Sebastian Wesselborg, Antje S. Löffler, Sebastian Alers, Alexandra M. Dieterle, Stefan Driessen, Klaus Schulze-Osthoff, Nadine Hoffmann, Björn Stork, Kirsten Lauber, Merle Daubrawa
Publikováno v:
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 25(9)
The protein kinase inhibitor staurosporine is one of the most potent and frequently used proapoptotic stimuli, although its mechanism of action is poorly understood. Here, we show that staurosporine as well as its analog 7-hydroxystaurosporine (UCN-0
Autor:
Simon G. Pfisterer, Sebastian Wesselborg, Sebastian Alers, Antje Grotemeier, Benoit Viollet, Florian Paasch, Merle Daubrawa, Alexandra M. Dieterle, Björn Stork, Tassula Proikas-Cezanne
Publikováno v:
Cellular signalling. 22(6)
Autophagy is a eukaryotic lysosomal bulk degradation system initiated by cytosolic cargo sequestration in autophagosomes. The Ser/Thr kinase mTOR has been shown to constitute a central role in controlling the initiation of autophagy by integrating mu