Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Florian P. C. Binder"'
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Akademický článek
A Structural-Reporter Group to Determine the Core Conformation of Sialyl Lewisx Mimetics
Autor: Beatrice Wagner, Florian P. C. Binder, Xiaohua Jiang, Tobias Mühlethaler, Roland C. Preston, Said Rabbani, Martin Smieško, Oliver Schwardt, Beat Ernst
Publikováno v: Molecules, Vol 28, Iss 6, p 2595 (2023)
The d-GlcNAc moiety in sialyl Lewisx (sLex, 1) acts predominantly as a linker to position the d-Gal and the l-Fuc moieties in the bioactive spatial orientation. The hypothesis has been made that the NHAc group of GlcNAc pushes the fucose underneath t
Externí odkaz: https://doaj.org/article/09c92691cdac462f95168204e153b667
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3
E-selectin ligand complexes adopt an extended high-affinity conformation
Autor: Roman P. Jakob, Timm Maier, Roland C. Preston, Christoph P. Sager, Florian P. C. Binder, Beat Ernst
Publikováno v: Journal of molecular cell biology
Journal of Molecular Cell Biology
E-selectin is a cell-adhesion molecule of the vascular endothelium that promotes essential leukocyte rolling in the early inflammatory response by binding to glycoproteins containing the tetrasaccharide sialyl Lewis(x) (sLe(x)). Efficient leukocyte r
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::869531a69d84f4eeeca3ab424e137624
https://doi.org/10.1093/jmcb/mjv046
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5
Pre-organization of the Core Structure of E-Selectin Antagonists
Autor: Ako Kato, Martin Smieško, John L. Magnani, Oliver Schwardt, Céline Weckerle, Said Rabbani, Brian Cutting, Daniel Schwizer, John T. Patton, Beatrice Wagner, Beat Ernst, Florian P. C. Binder
Publikováno v: Chem. Eur. J.
A new class of N acetyl dglucosamine (GlcNAc) mimics for Eselectin antagonists was designed and synthesized. The mimic consists of a cyclohexane ring substituted with alkyl substituents adjacent to the linking position of the fucose moiety. Incorpora
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89beb9685818af8f3524ae8912264889
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6
Sialyl Lewis(x): a 'pre-organized water oligomer'?
Autor: Katrin Lemme, Florian P. C. Binder, Roland C. Preston, Beat Ernst
Publikováno v: Angewandte Chemie (International ed. in English)
Organized and released: Sialyl Lewis(x) (sLe(x)) represents a "pre-organized water oligomer", that is, a surrogate for clustered water molecules attached to a scaffold. The impetus for sLe(x) binding to E-selectin is shown to be the high degree of pr
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbef96a3c4d898a77d4663634dafccf2
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7
E- and P-Selectin: Differences, Similarities and Implications for the Design of P-Selectin Antagonists
Autor: Beat Ernst, Florian P. C. Binder
Publikováno v: CHIMIA
CHIMIA, Vol 65, Iss 4 (2011)
Selectins form a family of Ca2+ -dependent carbohydrate binding proteins that mediate the initial step of leukocyte recruitment in the inflammatory process. Blocking of selectins is therefore considered a promising therapeutic approach to treat acute
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8ebb8d437056528d0064eae84118a89
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8
Kinetic properties of carbohydrate-lectin interactions: FimH antagonists
Autor: Lijuan Pang, Oliver Schwardt, Florian P. C. Binder, Beat Ernst, Giulio Navarra, Xiaohua Jiang, Said Rabbani, Meike Scharenberg
Publikováno v: ChemMedChem. 9(1)
The lectin FimH is terminally expressed on type 1 pili of uropathogenic Escherichia coli (UPEC), which is the main cause of urinary tract infections (UTIs). FimH enables bacterial adhesion to urothelial cells, the initial step of infection. Various m
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8d9bd103707f67187efcadf22d1cd54
https://pubmed.ncbi.nlm.nih.gov/24357503
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