Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Florian Pöll"'
Publikováno v:
PLoS ONE, Vol 7, Iss 6, p e39458 (2012)
The newly developed multireceptor somatostatin analogs pasireotide (SOM230), octreotide and somatoprim (DG3173) have primarily been characterized according to their binding profiles. However, their ability to activate individual somatostatin receptor
Externí odkaz:
https://doaj.org/article/72b018b5770648bb9ef6b75bb471d9b2
Publikováno v:
British Journal of Pharmacology. 167:1259-1270
BACKGROUND AND PURPOSE The molecular basis of agonist-selective signalling at the µ-opioid receptor is poorly understood. We have recently shown that full agonists such as [D-Ala2-MePhe4-Gly-ol]enkephalin (DAMGO) stimulate the phosphorylation of a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9dddb9582f0b91bd9fe89cc949348d9b
https://doi.org/10.1111/j.1476-5381.2012.02080.x
https://doi.org/10.1111/j.1476-5381.2012.02080.x
Publikováno v:
British Journal of Pharmacology. 164:298-307
BACKGROUND AND PURPOSE Morphine activates the µ-opioid receptor without causing its rapid endocytosis. In contrast, full agonists such as [d-Ala2-MePhe4-Gly-ol]enkephalin (DAMGO) or etonitazene stimulate a rapid and profound internalization. However
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f2b6f976f85d3d3e2bf237b56d3ffb4
https://doi.org/10.1111/j.1476-5381.2011.01382.x
https://doi.org/10.1111/j.1476-5381.2011.01382.x
Autor:
Florian Pöll, Andrea Kliewer, Jan Carlo Märtens, Anika Mann, Aline Petrich, Anne Strigli, Falko Nagel, Stefan Schulz
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 27(4)
The frequent overexpression of the somatostatin receptors sst2 and sst5 in neuroendocrine tumors provides the molecular basis for therapeutic application of novel multireceptor somatostatin analogs. Although the phosphorylation of the carboxyl-termin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df274b94bb8419d66ced5b024a84bd8
https://pubmed.ncbi.nlm.nih.gov/23418396
https://pubmed.ncbi.nlm.nih.gov/23418396
Autor:
Christian, Doll, Florian, Pöll, Kenneth, Peuker, Anastasia, Loktev, Laura, Glück, Stefan, Schulz
Publikováno v:
British journal of pharmacology. 167(6)
The molecular basis of agonist-selective signalling at the µ-opioid receptor is poorly understood. We have recently shown that full agonists such as [D-Ala(2)-MePhe(4)-Gly-ol]enkephalin (DAMGO) stimulate the phosphorylation of a number of carboxyl-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a08d8c2eee8cd9e2594517f87121a820
https://pubmed.ncbi.nlm.nih.gov/22725608
https://pubmed.ncbi.nlm.nih.gov/22725608
Publikováno v:
PLoS ONE
PLoS ONE, Vol 7, Iss 6, p e39458 (2012)
PLoS ONE, Vol 7, Iss 6, p e39458 (2012)
The newly developed multireceptor somatostatin analogs pasireotide (SOM230), octreotide and somatoprim (DG3173) have primarily been characterized according to their binding profiles. However, their ability to activate individual somatostatin receptor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86c07922975cd6d14ec3ff53fd57c711
https://pubmed.ncbi.nlm.nih.gov/22745760
https://pubmed.ncbi.nlm.nih.gov/22745760
Publikováno v:
The Journal of biological chemistry. 286(38)
Termination of signaling of activated G protein-coupled receptors (GPCRs) is essential for maintenance of cellular homeostasis. It is well established that β-arrestin redistributes to phosphorylated GPCRs and thereby facilitates desensitization of c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5526000cf24ff2d12640e6d8e0a47d3e
https://pubmed.ncbi.nlm.nih.gov/21795688
https://pubmed.ncbi.nlm.nih.gov/21795688
Publikováno v:
British journal of pharmacology. 164(2)
Morphine activates the µ-opioid receptor without causing its rapid endocytosis. In contrast, full agonists such as [d-Ala(2) -MePhe(4) -Gly-ol]enkephalin (DAMGO) or etonitazene stimulate a rapid and profound internalization. However, the detailed mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bf5c7e93a54b93f3f15ee6e068a33979
https://pubmed.ncbi.nlm.nih.gov/21449916
https://pubmed.ncbi.nlm.nih.gov/21449916
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 25(5)
The clinically used somatostatin (SS-14) analogs octreotide and pasireotide (SOM230) stimulate distinct species-specific patterns of sst(2A) somatostatin receptor phosphorylation and internalization. Like SS-14, octreotide promotes the phosphorylatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c56a3f0bd554a90770d9549e3fbeba53
https://pubmed.ncbi.nlm.nih.gov/21330405
https://pubmed.ncbi.nlm.nih.gov/21330405
Autor:
Amelie Lupp, Diana Lehmann, Mihaela Ginj, Ralf Stumm, Susann Illing, Stefan Schulz, Florian Pöll, Stefan Jacobs
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 24(2)
Pasireotide (SOM230) is currently under clinical evaluation as a successor compound to octreotide for the treatment of acromegaly, Cushing's disease, and carcinoid tumors. Whereas octreotide acts primarily via the sst(2A) somatostatin receptor, pasir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de2fccdc4f1d6ffde9fa2f1031ac8e63
https://pubmed.ncbi.nlm.nih.gov/20051480
https://pubmed.ncbi.nlm.nih.gov/20051480