Výsledky vyhledávání - "Florian N. M. Kühnle"

Studies on the Conformation of Boc-Protected (S)-(+)-Isovaline Homopeptide Methyl Esters in the Solid State and in Solution

Autor: Masakazu Tanaka, Florian N. M. Kühnle, Bernhard Jaun, Paul Seiler, Dieter Seebach, Christine Braun

Publikováno v: Liebigs Annalen. 1997:1697-1710

X-Ray diffraction analyses of the fully protected peptides Boc-[(S)-Iva]n-OMe (n = 3, 4, 6) reveal two independent molecules in the asymmetric unit. The structures of these can be described as β-turns or 310 helices (depending on the length of the o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a36b76202970b124e4a4502ca01a9f6
https://doi.org/10.1002/jlac.199719970811

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β-Peptides: Synthesis by Arndt-Eistert homologation with concomitant peptide coupling. Structure determination by NMR and CD spectroscopy and by X-ray crystallography. Helical secondary structure of a β-hexapeptide in solution and its stability towards pe

Autor: Hans Widmer, Dieter Seebach, Bruno Martinoni, Mark Overhand, Ulrich Hommel, Florian N. M. Kühnle, Lukas Oberer

Publikováno v: Helvetica Chimica Acta. 79:913-941

The β-hexapeptide (H-β-HVal-β-HAla-β-HLeu)2-OH (2) was prepared from the component L-β-amino acids by conventional peptide synthesis, including fragment coupling. A cyclo-β-tri- and a cyclo-β-hexapeptide were also prepared. The β-amino acids

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::059b48690b3fc18c6533959638e59904
https://doi.org/10.1002/hlca.19960790402

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FurtherC-Alkylations of CyclotetrapeptidesviaLithium and Phosphazenium (P4) Enolates: Discovery of a New Conformation

Autor: Dieter Seebach, Jennifer L. Matthews, Bernhard Jaun, Thomas Pietzonka, Olivier Bezencon, W. Bernd Schweizer, Florian N. M. Kühnle

Publikováno v: Helvetica Chimica Acta. 79:588-608

Four cyclotetrapeptides containing one (1, 2) or two (3, 4) chiral amino acids have been C-alkylated or C-hydroxyalkylated through Li+ or phosphazenium (P4 · H+) enolates. The reactions are completely diastereoselective (by NMR or HPLC analysis) wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::721c7184a2b1ddbbfddd803a39947ea9
https://doi.org/10.1002/hlca.19960790303

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Preparation, Structure, and Reactivity of Thioxo and Imino Derivatives of the Triolide (and Pentolide) from (R)-3-Hydroxybutanoic Acid

Autor: Dieter Seebach, Florian N. M. Kühnle, Andreas Brunner

Publikováno v: Helvetica Chimica Acta. 79:319-345

Reaction of the triolide 1 from (R)-3-hydroxybutanoic acid with Lawesson's reagent 5 leads to the mono-, di-, and trithio derivatives 6–8 which can be isolated in pure form (20–40% yields), and which have crystal structures very similar to the pa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::280a48bde2bb4dc94bd5945d952daeb3
https://doi.org/10.1002/hlca.19960790202

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Preparation of the PdCl2Complex of TADDOP, the Bis(diphenylphosphinite) of TADDOL: Use in enantioselective 1,3-diphenylallylations of nucleophiles and discussion of the mechanism

Autor: Beat Weber, W. Bernd Schweizer, Florian N. M. Kühnle, M. Hayakawa, Dieter Seebach, Edmée Devaquet, Alexander Ernst

Publikováno v: Helvetica Chimica Acta. 78:1636-1650

Reaction of the tartrate-derived diol (R,R)-α,α,α′,α′-tetraphenyl-2,2-dimethyl-1,3-dioxolane-4,5-dimethanol (TADDOL) with chlorodiphenylphosphane gives a new bis(diphenylphosphanyl) ligand (TADDOP). The complex 4 formed with PdCl2 has been cr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f61ccd5c00a568b5fa13ecf17c10e36
https://doi.org/10.1002/hlca.19950780703

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Preparation, Structure, and Properties of All Possible Cyclic Dimers (Diolides) of 3-Hydroxybutanoic Acid

Autor: Michael Schulte, Joachim Kinkel, Florian N. M. Kühnle, Dieter Seebach, Torsten Hoffmann

Publikováno v: Helvetica Chimica Acta. 78:1525-1540

In connection with the proposed structure of a trans-membrane cellular ion channel consisting of a complex between poly[(R)-3-hydroxy butanoate] (P(3-HB)) and calcium polyphosphate, CaPPi (ca. 150 units each), which is supposed to contain s-cis-bonds

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2dad2349a6edfc7031e81ffb522c8636
https://doi.org/10.1002/hlca.19950780611

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Preparation and Structural Analysis of Several New α,α,α′,α′-Tetraaryl-1,3-dioxolane-4,5-dimethanols (TADDOL's) and TADDOL analogs, their evaluation as titanium ligands in the enantioselective addition of methyltitanium and diethylzinc reagents to benzald

Autor: Robert E. Gawley, Yoshio N. Ito, Albert K. Beck, Juraj Tuleja, Yan Ming Wang, Dieter Seebach, Xavier Ariza, Andrej Boháč, Florian N. M. Kühnle, Camille Ganter

Publikováno v: Helvetica Chimica Acta. 77:2071-2110

Preparation and screening of twenty new ligands, all analogs of α,α,α′,α′-tetraaryl-1,3-dioxolane-4,5-dimethanol (TADDOL), for the Ti-catalyzed asymmetric addition of methyltri(isopropoxy)titanium and diethylzinc to benzaldehyde are described

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f06bebce5206f9a7fff91841bfba6597
https://doi.org/10.1002/hlca.19940770802

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Preparation and Structure of Oligolides from (R)-3-Hydroxypentanoic Acid and comparison with the hydroxybutanoic-acid derivatives: A small change with large consequences

Autor: Torsten Hoffmann, Urs D. Lengweiler, Florian N. M. Kühnle, Dieter Seebach

Publikováno v: Helvetica Chimica Acta. 77:2007-2034

Cyclic oligomers of (R)-3-hydroxyvaleric acid (3-HV) are prepared from the monomer by three different methods, giving various ratios of the oligomers. The macrocycles containing three to twelve 3-HV units (12- to 48-membered rings) are isolated in pu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bf2e0e2f00936f92cb57d77acccaa814
https://doi.org/10.1002/hlca.19940770727

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Diastereoselective Michael Additions of Chiral Imidazolidines to Trityl Enones

Autor: Florian N. M. Kühnle, Elmar Pfammatter, Volker Gramlich, Ilario Tironi, Dieter Seebach, Stefan Portmann, Tobias Bremi

Publikováno v: Liebigs Annalen der Chemie. 1992:1145-1151

The enolates A and C of t-butyl (R)-2-t-butyl-3-methyl-4-oxo-1-imidazolidinecarboxylate (1, Boc-BMI) and of 1-t-butyl 5-methyl (2R,5S)-2-t-butyl-3-methyl-1,5-imidazolidinedicarboxylate (3) and t-butyl (R)-2-t-butyl-5-lithio-3-methyl-1-imidazolidineca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ad945a82d8f83656e865bca03b2b0697
https://doi.org/10.1002/jlac.1992199201188

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