Zobrazeno 1 - 10 of 22 pro vyhledávání: '"Florian Montel"'
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Akademický článek
Differential analyte derivatization enables unbiased MALDI-TOF-based high-throughput screening: A proof-of-concept study for the discovery of catechol-o-methyltransferase inhibitors
Autor: Martin Winter, Roman P. Simon, Yuting Wang, Tom Bretschneider, Margit Bauer, Aniket Magarkar, Wolfgang Reindl, Amaury Fernández-Montalván, Florian Montel, Frank H. Büttner
Publikováno v: SLAS Discovery, Vol 27, Iss 5, Pp 287-297 (2022)
Recent advances in label-free high-throughput screening via matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry (MS) offer unprecedented opportunities for the identification of novel chemical starting points in ta
Externí odkaz: https://doaj.org/article/88ff55c9f02c4911aa58f3bdb94f7101
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2
Treatment of congenital thrombocytopenia and decreased collagen reactivity in G6b-B–deficient mice
Autor: Alexandra Mazharian, Blandine Maître, Alicia Bornert, Desline Hennequin, Marc Lourenco-Rodrigues, Mitchell J. Geer, Christopher W. Smith, Silke Heising, Michaela Walter, Florian Montel, Lucy S. K. Walker, Henri de la Salle, Steve P. Watson, Christian Gachet, Yotis A. Senis
Publikováno v: Blood Advances. 7:46-59
Mice lacking the immunoreceptor tyrosine-based inhibition motif-containing co-inhibitory receptor G6b-B (Mpig6b, G6b knockout, KO) are born with a complex megakaryocyte (MK) per platelet phenotype, characterized by severe macrothrombocytopenia, expan
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::620c59da210464487d02a6daff4999b7
https://doi.org/10.1182/bloodadvances.2022008873
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6
Optimization of 8-Hydroxyquinolines as Inhibitors of Catechol O-Methyltransferase
Autor: Martyn D. Wood, Anna Kolobova, Florence Moureau, Glen Ernst, Daniel Akuma, Ingrid P. Buchler, Florian Montel, James C. Barrow, Huijun Wei, Dominique Swinnen, Gregory V. Carr, Michael S. Poslusney, Emilie Jigorel, Vinh Au, Pablo De León, Michael DePasquale, Martha Kimos, Monika Sarah E.D. Schulze, Yifang Huang
Publikováno v: Journal of Medicinal Chemistry. 61:9647-9665
A series of 8-hydroxy quinolines were identified as potent inhibitors of catechol O-methyltransferase (COMT) with selectivity for the membrane-bound form of the enzyme. Small substituents at the 7-position of the quinoline were found to increase meta
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0548e3750c7972bb8419983749ba6e77
https://doi.org/10.1021/acs.jmedchem.8b01126
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8
Synthesis and Preclinical Evaluation of11C-UCB-J as a PET Tracer for Imaging the Synaptic Vesicle Glycoprotein 2A in the Brain
Autor: Marie-Christine Vandergeten, Daniel Holden, Yiyun Huang, Jonas Hannestad, Nabeel Nabulsi, Soheila Najafzadeh, Joël Mercier, Nathalie Price, Shu-fei Lin, Anand K. Deo, Martyn Wood, Stephane Carre, Teresa Lara-Jaime, Richard E. Carson, Florian Montel, Marc Laruelle
Publikováno v: Journal of Nuclear Medicine. 57:777-784
The synaptic vesicle glycoprotein 2A (SV2A) is found in secretory vesicles in neurons and endocrine cells. PET with a selective SV2A radiotracer will allow characterization of drugs that modulate SV2A (e.g., antiepileptic drugs) and potentially could
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c38f388f80ab022865ccdb070c3f492e
https://doi.org/10.2967/jnumed.115.168179
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9
Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule
Autor: Florian Montel, Gisela Schnapp, Ralf Heilker, Supriyo Bhattacharya, Christofer S. Tautermann, Scott Hobson, Sven Thamm, Christian Eickmeier, Dennis Fiegen, Frank H. Büttner, Ulrike Gross, Nagarajan Vaidehi, Stefan Hoerer, Volker Mack, Marc Grundl, Markus Zeeb, Stefan Peters, Andreas H. Luippold, Florian Binder
Publikováno v: Journal of medicinal chemistry. 62(1)
Protein tyrosine phosphatase non-receptor type 5 (PTPN5, STEP) is a brain specific phosphatase that regulates synaptic function and plasticity by modulation of N-methyl-d-aspartate receptor (NMDAR) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed9ae75015aa01170c721b74c0bcca15
https://pubmed.ncbi.nlm.nih.gov/30207464
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10
Multiple Binding Sites Contribute to the Mechanism of Mixed Agonistic and Positive Allosteric Modulators of the Cannabinoid CB1 Receptor
Autor: Oliver Hucke, Florian Montel, Christofer S. Tautermann, Noureldin Saleh, Radoslaw Lipinski, Timothy Clark, Boris Ferger, Gert Kramer, Peter W. Hildebrand, Esther Schmidt
Publikováno v: Angewandte Chemie (International ed. in English). 57(10)
The cannabinoid CB1 receptor (CB1R) is an abundant metabotropic G-protein-coupled receptor that has been difficult to address therapeutically because of CNS side effects exerted by orthosteric drug candidates. Recent efforts have focused on developin
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62766dfc7df67ae20aa5234b7489e1b2
https://pubmed.ncbi.nlm.nih.gov/29314474
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