Výsledky vyhledávání - "Florian Manzenrieder"

The Regulatory Domain Stabilizes the p53 Tetramer by Intersubunit Contacts with the DNA Binding Domain

Autor: Natascha Jennifer Küpper, Marco Retzlaff, Johannes Buchner, Florian Manzenrieder, Stephan Lagleder, Julia Rohrberg, Jirka Peschek, Horst Kessler, Alexander Bepperling

Publikováno v: Journal of Molecular Biology. 425:144-155

The tumor suppressor protein p53 is often referred to as the guardian of the genome. In the past, controversial findings have been presented for the role of the C-terminal regulatory domain (RD) of p53 as both a negative regulator and a positive regu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::210ccb002bfebcbdddf05c019530c5e2
https://doi.org/10.1016/j.jmb.2012.10.015

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Engineered Mutations Change the Structure and Stability of a Virus-Like Particle

Autor: M. G. Finn, Clinton S. Potter, Alexandra Castillejos, Bridget Carragher, Marisa L. Hovlid, Cody J. Higginson, Alexander A. Kislukhin, Melody G. Campbell, Florian Manzenrieder, Neil R. Voss, Jason D. Fiedler

Publikováno v: Biomacromolecules. 13:2339-2348

The single-coat protein (CP) of bacteriophage Qβ self-assembles into T = 3 icosahedral virus-like particles (VLPs), of interest for a wide range of applications. These VLPs are very stable, but identification of the specific molecular determinants o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37728c9451f1d502d06bec2f463e0264
https://doi.org/10.1021/bm300590x

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Colorful Virus-like Particles: Fluorescent Protein Packaging by the Qβ Capsid

Autor: M. G. Finn, James C. Paulson, Corwin M. Nycholat, Florian Manzenrieder, Jin Kyu Rhee, Jason D. Fiedler, Marisa L. Hovlid, Hiroaki Kitagishi, Steven D. Brown

Publikováno v: Biomacromolecules. 12:3977-3981

Qβ virus-like particles encapsulating multiple copies of fluorescent proteins were generated in high yields using a modular system enhanced by specific engineered RNA--protein interactions. The resulting particles were structurally indistinguishable

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6f94a4c54e65504d16d36ef51cb8dc2
https://doi.org/10.1021/bm200983k

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Synthesis and biological evaluation of phosphino dipeptide isostere inhibitor of human β-secretase (BACE1)

Autor: Florian Manzenrieder, Timo Huber, Cornelia Dorner-Ciossek, Andreas O. Frank, Horst Kessler

Publikováno v: Bioorganic & Medicinal Chemistry. 15:4136-4143

Phosphino dipeptide (PDP) isosteres are known to be useful analogues of the transition state of metalloprotease substrates. Here we describe the use of this unit for the design of aspartic protease inhibitors. A PDP analogue of OM00-3, a potent BACE1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7755f5048af6178b592ee758836154fd
https://doi.org/10.1016/j.bmc.2007.03.072

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Behavior of primary human osteoblasts on trimmed and sandblasted Ti6Al4V surfaces functionalized with integrin avß3-selective cyclic RGD peptides

Autor: Florian Manzenrieder, Carlos Mas-Moruno, Rainer Burgkart, Horst Kessler, Stefanie Neubauer, Ute Reuning, Petra M. Dorfner

Publikováno v: UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Recercat. Dipósit de la Recerca de Catalunya
Universitat Jaume I

It is well known that functionalization of surfaces with cell adhesive peptides mimicking the integrin binding motif of extracellular matrix proteins is a feasible approach to improve osseointegration of implant materials. Also, modi- fication of the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::990ba32d320bac972ed2a65f5657962b
http://hdl.handle.net/2117/22773

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Resin-supported catalysts for CuAAC click reactions in aqueous or organic solvents

Autor: Stanislav I. Presolski, M. G. Finn, Sreeman K. Mamidyala, Florian Manzenrieder

Publikováno v: ACS combinatorial science. 14(10)

The copper-catalyzed azide–alkyne cycloaddition click reaction is a valuable process for the synthesis of libraries of drug candidates, derivatized polymers and materials, and a wide variety of other functional molecules. In some circumstances, the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a55800ee4bc40ce3a83a30d954922ea
https://pubmed.ncbi.nlm.nih.gov/22946559

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Tailoring of integrin ligands: probing the charge capability of the metal ion-dependent adhesion site

Autor: Markus Bollinger, Stefanie Neubauer, Ettore Novellino, Georg Moessmer, Vittorio Limongelli, Amnon Hoffman, Alexander Bochen, Luciana Marinelli, Joseph Fanous, Roman Kolb, Reinhard Pell, Florian Manzenrieder, Horst Kessler, Wolfgang Lindner

Intervention in integrin-mediated cell adhesion and integrin signaling pathways is an ongoing area of research in medicinal chemistry and drug development. One key element in integrin-ligand interaction is the coordination of the bivalent cation at t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47ded6d4a7c5240e45b9276ead8cc3d5
http://hdl.handle.net/11588/427048

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Stabilization of Virus-Like Particles with Poly(2-oxazoline)s**

Autor: Rainer Jordan, Robert Luxenhofer, M. G. Finn, Marco Retzlaff, Florian Manzenrieder

Since the introduction of virus like particles (VLPs), as nanoscale building blocks,[1] they have become a favored material to fill the gap between supramolecular chemistry and microfabricated systems for medicine, materials science, and biotechnolog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::121fc11910f8c0a89e599ee31db50ae2
https://europepmc.org/articles/PMC3574789/

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Introducing lasso peptides as molecular scaffolds for drug design: Engineering of an integrin antagonist

Autor: Florenz Sasse, Carlos Mas-Moruno, Mohamed A. Marahiel, Thomas A. Knappe, Florian Manzenrieder, Horst Kessler, Uwe Linne, Xiulan Xie

Publikováno v: UPCommons. Portal del coneixement obert de la UPC
Universitat Politècnica de Catalunya (UPC)
Recercat. Dipósit de la Recerca de Catalunya
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Thumbnail image of graphical abstract Tightening the noose: Lasso peptides are a class of stable bacterial peptides with unique characteristics that encourage their application in drug design. Epitope grafting of the integrin binding motif RGD onto t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3113b82dbb6296946af7afe7cc261afc
http://hdl.handle.net/2117/22784

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