Výsledky vyhledávání - "Florian M, Wurm"

Akademický článek

Alpha1-antitrypsin improves survival in murine abdominal sepsis model by decreasing inflammation and sequestration of free heme

Autor: Jan D. Zemtsovski, Srinu Tumpara, Sonja Schmidt, Vijith Vijayan, Andreas Klos, Robert Laudeley, Julia Held, Stephan Immenschuh, Florian M. Wurm, Tobias Welte, Hermann Haller, Sabina Janciauskiene, Nelli Shushakova

Publikováno v: Frontiers in Immunology, Vol 15 (2024)

BackgroundExcessive inflammation, hemolysis, and accumulation of labile heme play an essential role in the pathophysiology of multi-organ dysfunction syndrome (MODS) in sepsis. Alpha1-antitrypsin (AAT), an acute phase protein with heme binding capaci

Externí odkaz: https://doaj.org/article/44b182a20fed4dd3a42717018dafa97b

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Akademický článek

Human PBMCs Form Lipid Droplets in Response to Spike Proteins

Autor: Kokilavani Sivaraman, Paco Pino, Guillaume Raussin, Stephanie Anchisi, Charles Metayer, Nicolas Dagany, Julia Held, Sabine Wrenger, Tobias Welte, Maria J. Wurm, Florian M. Wurm, Beata Olejnicka, Sabina Janciauskiene

Publikováno v: Microorganisms, Vol 11, Iss 11, p 2683 (2023)

Intracellular lipid droplets (LDs) can accumulate in response to inflammation, metabolic stresses, and other physiological/pathological processes. Herein, we investigated whether spike proteins of SARS-CoV-2 induce LDs in human peripheral blood monon

Externí odkaz: https://doaj.org/article/db2413774549499d9f185926ebfc3649

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Akademický článek

High-Titer Neutralizing Antibodies against the SARS-CoV-2 Delta Variant Induced by Alhydroxyquim-II-Adjuvanted Trimeric Spike Antigens

Publikováno v: Microbiology Spectrum, Vol 10, Iss 1 (2022)

ABSTRACT Global control of COVID-19 will require the deployment of vaccines capable of inducing long-term protective immunity against SARS-CoV-2 variants. In this report, we describe an adjuvanted subunit candidate vaccine that affords elevated, sust

Externí odkaz: https://doaj.org/article/215dbedfcba04207b2b7b97f024ad384

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Akademický článek

Affordable SARS-CoV-2 protein vaccines for the pandemic endgame

Autor: James A. Triccas, Joeri Kint, Florian M. Wurm

Publikováno v: npj Vaccines, Vol 7, Iss 1, Pp 1-2 (2022)

Externí odkaz: https://doaj.org/article/d3f97aa75a69471e8dffc24d70f6bb16

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Akademický článek

Scalable Production of AAV Vectors in Orbitally Shaken HEK293 Cells

Autor: Daniel Blessing, Gabriel Vachey, Catherine Pythoud, Maria Rey, Vivianne Padrun, Florian M. Wurm, Bernard L. Schneider, Nicole Déglon

Publikováno v: Molecular Therapy: Methods & Clinical Development, Vol 13, Iss , Pp 14-26 (2019)

Adeno-associated virus (AAV) vectors are currently among the most commonly applied for in vivo gene therapy approaches. The evaluation of vectors during clinical development requires the production of considerable amounts of highly pure and potent ve

Externí odkaz: https://doaj.org/article/c64df449fff64ecabe0fef84dace7fbe

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Akademický článek

Designs and Characterization of Subunit Ebola GP Vaccine Candidates: Implications for Immunogenicity

Autor: Valentina Agnolon, Divor Kiseljak, Maria J. Wurm, Florian M. Wurm, Charlotte Foissard, Fabrice Gallais, Sarah Wehrle, César Muñoz-Fontela, Laurent Bellanger, Bruno Emanuel Correia, Giampietro Corradin, François Spertini

Publikováno v: Frontiers in Immunology, Vol 11 (2020)

The humoral responses of Ebola virus (EBOV) survivors mainly target the surface glycoprotein GP, and anti-GP neutralizing antibodies have been associated with protection against EBOV infection. In order to elicit protective neutralizing antibodies th

Externí odkaz: https://doaj.org/article/007fe3b6b33a4a30bd1fc66d32a650be

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Akademický článek

The Delivery of α1-Antitrypsin Therapy Through Transepidermal Route: Worthwhile to Explore

Autor: Srinu Tumpara, Beatriz Martinez-Delgado, Gema Gomez-Mariano, Bin Liu, David S. DeLuca, Elena Korenbaum, Danny Jonigk, Frank Jugert, Florian M. Wurm, Maria J. Wurm, Tobias Welte, Sabina Janciauskiene

Publikováno v: Frontiers in Pharmacology, Vol 11 (2020)

Human α1-antitrypsin (AAT) is an abundant acute phase glycoprotein expressing anti-protease and immunomodulatory activities, and is used as a biopharmaceutical to treat patients with inherited AAT deficiency. The pleiotropic properties of AAT provid

Externí odkaz: https://doaj.org/article/d649110fad584ba68c3fdad1618e010c

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