The chemokine CXCL13 is a prognostic marker in clinically isolated syndrome (CIS).

Autor: Johannes Brettschneider, Anne Czerwoniak, Makbule Senel, Lubin Fang, Jan Kassubek, Elmar Pinkhardt, Florian Lauda, Tamara Kapfer, Sarah Jesse, Vera Lehmensiek, Albert C Ludolph, Markus Otto, Hayrettin Tumani

Publikováno v: PLoS ONE, Vol 5, Iss 8, p e11986 (2010)

BACKGROUND: There is increasing recognition of the importance of B lymphocytes in the immunopathogenesis of multiple sclerosis (MS), encouraging the evaluation of B cell-associated biomarkers in the cerebrospinal fluid (CSF). We aimed to evaluate the

Externí odkaz: https://doaj.org/article/eb2aeed1701b47af9a916096b56020ed

Longitudinal optic neuritis-unrelated visual evoked potential changes in NMO spectrum disorders

Autor: I. Kleiter, Martin W. Hümmert, Tania Kümpfel, Joachim Havla, Ilya Ayzenberg, Hanna Zimmermann, Luisa Klotz, Kim Lea Young, Marius Ringelstein, Christian Geis, Philipp Albrecht, Michael Deppe, Hans-Peter Hartung, Luise Röpke, Nele Retzlaff, Matthias Kaste, Alexander Klistorner, Orhan Aktas, Corinna Trebst, Christoph Schroeder, Axel Haarmann, Paulus S. Rommer, Martin S. Weber, Mathias Buttmann, Friedemann Paul, Florian Lauda, Hannah L. Pellkofer, Alexander U. Brandt, Uwe K. Zettl, Kerstin Hellwig, Hayrettin Tumani, Jens Harmel, B. Wildemann, Sven Jarius, Wael Marouf, Jan-Patrick Stellmann, Jonas Graf, Pawel Kermer

Publikováno v: Neurology
Neurology, 2020, 94 (4), pp.e407-e418. ⟨10.1212/WNL.0000000000008684⟩
Neurology, American Academy of Neurology, 2020, 94 (4), pp.e407-e418. ⟨10.1212/WNL.0000000000008684⟩

ObjectiveTo investigate if patients with neuromyelitis optica spectrum disorder (NMOSD) develop subclinical visual pathway impairment independent of acute attacks.MethodsA total of 548 longitudinally assessed full-field visual evoked potentials (VEP)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb3376da0d5f35444d632b59d1849fdf
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/93018

Lipid-specific immunoglobulin M bands in cerebrospinal fluid are associated with a reduced risk of developing progressive multifocal leukoencephalopathy during treatment with natalizumab

Autor: Francisco Coret, Santiago Díaz, Albert Saiz, Lamberto Landete, Hayrettin Tumani, Lucienne Costa-Frossard, Oscar Fernandez, Fernando Sánchez-López, Clara de Andrés, Ricardo Fernandez-Bolanos, Bonaventura Casanova, María Simó-Castelló, Mar Tintoré, Carmen Espejo, Alfonso Muriel, Ester Quintana, José C. Álvarez-Cermeño, Javier Olascoaga, Xavier Montalban, Domingo Pérez, Alvaro Prada, J.A. García-Merino, Laura Navarro, Maria Isabel García-Sánchez, Roberto Alvarez-Lafuente, Manuel Menéndez-González, Thomas Masterman, Pedro J. Serrano-Castro, Florian Lauda, Manuel Comabella, Rafael Arroyo, Guillermo Izquierdo, Katharina Fink, Mercedes Espiño, Carmen Picón, Eduardo Agüera, Lluís Ramió-Torrentà, Amit Bar-Or, Agustín Oterino, Eulalia Rodríguez-Martín, Sara Llufriu, Luisa M. Villar, Alberto Tuñon, Laura Leyva

Publikováno v: Annals of Neurology. 77:447-457

Objective Progressive multifocal leukoencephalopathy (PML) is a serious side effect associated with natalizumab treatment in multiple sclerosis (MS). PML risk increases in individuals seropositive for anti–John Cunningham virus (JC) antibodies, wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8482dc3530b4e42613bf004ff78ea6ab
https://doi.org/10.1002/ana.24345

Influence of female sex and fertile age on neuromyelitis optica spectrum disorders

Autor: Joachim Havla, Bernhard Hemmer, Klemens Ruprecht, Katrin Fischer, Anna Gahlen, Ulrich Hofstadt-van Oy, Simon Schuster, Jürgen H. Faiss, Lena Zeltner, Marius Ringelstein, Martin Marziniak, Wael Marouf, Achim Berthele, Ulf Ziemann, Christoph Kleinschnitz, Nemos, Christian Geis, Christoph Mayer, Brigitte Wildemann, Matthias Schwab, Friedemann Paul, Oliver Neuhaus, Alexander Winkelmann, Lioba Rückriem, Klaus-Dieter Wernecke, Tania Kümpfel, Martin Stangel, Robert Weissert, Kerstin Hellwig, Corinna Trebst, Florence Pache, Nadja Borisow, Ralf A. Linker, Markus Krumbholz, Florian Lauda, Orhan Aktas, Hayrettin Tumani, Jan-Patrick Stellmann, Klemens Angstwurm, Florian Then Bergh, Ingo Kleiter, Sven Jarius

Background: Gender and age at onset are important epidemiological factors influencing prevalence, clinical presentation, and treatment response in autoimmune diseases. Objective: To evaluate the impact of female sex and fertile age on aquaporin-4-ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c429c6a426ca2ed8e10c6b2977cd3092
https://opus4.kobv.de/opus4-fau/files/11234/Borisow_influence.pdf

Unexpectedly low prevalence of intracerebral hemorrhages in sporadic cerebral amyloid angiopathy

Autor: Florian Lauda, Johannes Attems, Kurt A. Jellinger

Publikováno v: Journal of Neurology. 255:70-76

In a retrospective study of a consecutive autopsy series of 2060 elderly subjects (mean age 78.5 +/- 6.8 SD years), sporadic cerebral amyloid angiopathy (CAA) of various degrees was detected in 73.2% and in 98.5% of autopsy-confirmed cases of typical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::753d052ca62e46972481b798f610ef39
https://doi.org/10.1007/s00415-008-0674-4