Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Florian Lasch"'
Publikováno v:
Contemporary Clinical Trials Communications, Vol 38, Iss , Pp 101266- (2024)
Background: The estimands framework represents a significant innovation for the design, conduct, analysis, and interpretation of clinical trials. An aim of the framework is to increase precision and transparency on the handling of intercurrent events
Externí odkaz:
https://doaj.org/article/5d7639251c6f447cbe1647f822544dc9
Autor:
Verena Scheper, Melanie Schmidtheisler, Florian Lasch, Heiko von der Leyen, Armin Koch, Jana Schwieger, Andreas Büchner, Anke Lesinski-Schiedat, Thomas Lenarz
Publikováno v:
Trials, Vol 21, Iss 1, Pp 1-14 (2020)
Abstract Background The standard therapy for patients suffering from sensorineural hearing loss is cochlear implantation. The insertion of the electrode array into the cochlea, with potential mechanical trauma and the presence of this foreign body in
Externí odkaz:
https://doaj.org/article/0e03aba5689f4ab3943e9853368e523a
Publikováno v:
Trials, Vol 20, Iss 1, Pp 1-6 (2019)
Abstract Registry-based randomized controlled trials (RCTs) are presumed to include a less-selected patient population and thus to have enhanced generalizability compared to conventional RCTs. However, this view disregards the levels of patient selec
Externí odkaz:
https://doaj.org/article/c5a7b836b7454bf28b386a7c3ace7f9c
Autor:
Florian Lasch, Annika Karch, Armin Koch, Thorsten Derlin, Andreas Voskrebenzev, Tawfik Moher Alsady, Marius M. Hoeper, Henning Gall, Fritz Roller, Sebastian Harth, Dagmar Steiner, Gabriele Krombach, Hossein Ardeschir Ghofrani, Fabian Rengier, Claus Peter Heußel, Ekkehard Grünig, Dietrich Beitzke, Marcus Hacker, Irene M. Lang, Jürgen Behr, Peter Bartenstein, Julien Dinkel, Kai-Helge Schmidt, Karl-Friedrich Kreitner, Thomas Frauenfelder, Silvia Ulrich, Okka W. Hamer, Michael Pfeifer, Christopher S. Johns, David G. Kiely, Andrew James Swift, Jim Wild, Jens Vogel-Claussen
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 7 (2020)
The diagnostic strategy for chronic thromboembolic pulmonary hypertension (CTEPH) is composed of two components required for a diagnosis of CTEPH: the presence of chronic pulmonary embolism and an elevated pulmonary artery pressure. The current guide
Externí odkaz:
https://doaj.org/article/5f59f8e64ece418cb0a4d9c97cb1e850
Publikováno v:
Orphanet Journal of Rare Diseases, Vol 12, Iss 1, Pp 1-6 (2017)
Abstract In planning a clinical trial for demonstrating the efficacy of pioglitazone to resolve leukoplakia and erythroplakia in Fanconi anemia patients we had to discuss the need for a randomized controlled trial particularly under sample-size restr
Externí odkaz:
https://doaj.org/article/7065f8a170e0433699c385ae6919a833
Autor:
Florian Lasch, Lorenzo Guizzaro
Publikováno v:
Pharmaceutical Statistics. 21:1258-1280
The COVID-19 pandemic has affected clinical trials across disease areas, raising the questions how interpretable results can be obtained from impacted studies. Applying the estimands framework, analyses may seek to estimate the treatment effect in th
Publikováno v:
Statistics in Biopharmaceutical Research. 15:386-399
In studying a potential disease-modifying treatment for Alzheimer’s Disease, the use of currently available symptomatic medicines—being proportional to the disease progression—can mask the disease-modifying effect. A solution in line with the E
Autor:
Jens Vogel-Claussen, Florian Lasch, Benjamin-Alexander Bollmann, Katharina May, Alexander Kuhlmann, Gerald Schmid-Bindert, Rudolf Kaaks, Jörg Barkhausen, Sabine Bohnet, Martin Reck
Publikováno v:
RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. 194(12)
Despite the high prevalence and mortality of lung cancer and proven effectiveness of low-dose computed tomography (LDCT) to reduce mortality, Germany still lacks a national screening program. The German Institute for Quality and Efficiency in Health
Autor:
Florian Lasch, Thomas Sanjay Weber-Spickschen, Hauke Horstmann, Werner Krutsch, Pascal Medico
Publikováno v:
Open Access Journal of Sports Medicine. 11:43-49
Context Isokinetic testing is used as a standard tool in measuring strength in professional athletes. It is often used to evaluate improvement during rehabilitation. The disadvantages of isokinetic testing include its costs, the fact that it is not p
Autor:
Florian Lasch, Eftychia‐Eirini Psarelli, Ralf Herold, Andrea Mattsson, Lorenzo Guizzaro, Frank Pétavy, Anja Schiel
Publikováno v:
Clinical pharmacology and therapeutics. 111(5)
The coronavirus disease 2019 (COVID-19) pandemic has a major impact not only on public health and daily living, but also on clinical trials worldwide. To investigate the potential impact of the COVID-19 pandemic on the initiation of clinical trials,