Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Florian Kast"'
Autor:
Florian Kast, Martin Schwill, Jakob C. Stüber, Svende Pfundstein, Gabriela Nagy-Davidescu, Josep M. Monné Rodríguez, Frauke Seehusen, Christian P. Richter, Annemarie Honegger, Karen Patricia Hartmann, Thomas G. Weber, Felix Kroener, Patrick Ernst, Jacob Piehler, Andreas Plückthun
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
HER2 acts an oncogenic driver in numerous cancers. Here, the authors design an anti-HER2 biparatopic and tetravalent IgG fusion with inhibitory effects in a xenograft model.
Externí odkaz:
https://doaj.org/article/bbc4cba63fcc425a86335df0941f73d7
Publikováno v:
OncoImmunology, Vol 10, Iss 1 (2021)
Based on the success of tumor-infiltrating lymphocytes (TIL)-based therapies, personalized adoptive cell therapies (ACT) targeting neoantigens have the potential to become a disruptive technology and lead to highly effective treatments for cancer pat
Externí odkaz:
https://doaj.org/article/e35d59547b204fe29fac1882703dfb2d
Autor:
K. Patricia Hartmann, Merel van Gogh, Patrick C. Freitag, Florian Kast, Gabriela Nagy-Davidescu, Lubor Borsig, Andreas Plückthun
Fibroblast activation protein (FAP) is a cell surface serine protease that is highly expressed on reactive stromal fibroblasts, such as cancer-associated fibroblasts (CAFs), and generally absent in healthy adult tissues. FAP expression in the tumor s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9326671c305c29f8d4f5d75b38812fa9
https://doi.org/10.1101/2022.12.19.520931
https://doi.org/10.1101/2022.12.19.520931
Autor:
Florian Kast, Pavol Miškovský, Andreas Plückthun, Jonas V. Schaefer, Michal Nemergut, Gabriel Žoldák, Erik Sedlák
Publikováno v:
Protein Science. 26:2229-2239
Monoclonal antibodies of the immunoglobulin G (IgG) type have become mainstream therapeutics for the treatment of many life-threatening diseases. For their successful application in the clinic and a favorable cost-benefit ratio, the design and formul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfe89eae12300b6c7a22d52c7e69cdaa
https://doi.org/10.1002/pro.3278
https://doi.org/10.1002/pro.3278
Cell surface proteins are key regulators of fundamental cellular processes and, therefore, often at the root of human diseases. Thus, a large number of targeted drugs which are approved or under development act upon cell surface proteins. Although do
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b64bb03cf7fa9b585bfc7d7ed9abb50
https://www.zora.uzh.ch/id/eprint/174104/
https://www.zora.uzh.ch/id/eprint/174104/
Autor:
Martin Schwill, Florian Kast, Andreas Plückthun, Forest M. White, Rastislav Tamaskovic, Aaron Gajadhar
Publikováno v:
PMC
Drug-induced compensatory signaling and subsequent rewiring of the signaling pathways that support cell proliferation and survival promote the development of acquired drug resistance in tumors. Here, we sought to analyze the adaptive kinase response
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5358d80ba0d647adb0c969228c7b0ccd
https://www.zora.uzh.ch/id/eprint/174010/
https://www.zora.uzh.ch/id/eprint/174010/
Autor:
Herbert Michlmayr, Gerlinde Wiesenberger, Krisztian Twaruschek, Florian Kastner, Marta M. Sopel, Christian Hametner, Franz Berthiller, Gerhard Adam
Publikováno v:
Frontiers in Sustainable Food Systems, Vol 7 (2024)
The use of lactic acid bacteria as a low-cost sustainable management tool to prevent further build-up of Fusarium mycotoxins during grain storage is increasingly propagated. It has been reported that even deoxynivalenol contamination already formed i
Externí odkaz:
https://doaj.org/article/3ff8addecba041d4b08a9e5be690f3ad
Autor:
Hartmut H. Niemann, Luisa Iamele, Florian Kast, Timo Meyer, Andreas Plückthun, Fabio Andres, Jakob C. Stüber, Ermanno Gherardi
Publikováno v:
Journal of molecular biology. 431(10)
MET, the product of the c-MET proto-oncogene, and its ligand hepatocyte growth factor/scatter factor (HGF/SF) control survival, proliferation and migration during development and tissue regeneration. HGF/SF-MET signaling is equally crucial for growth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b4bf078fac0e630fdf82379b8b2207c
https://pubmed.ncbi.nlm.nih.gov/30930049
https://pubmed.ncbi.nlm.nih.gov/30930049
Biophysical properties of antibody-based biopharmaceuticals are a critical part of their release criteria. In this context, finding the appropriate formulation is equally important as optimizing their intrinsic biophysical properties through protein
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33c1a8f3dd08335c2eaa71f2747103a1
https://europepmc.org/articles/PMC5973700/
https://europepmc.org/articles/PMC5973700/
Autor:
Michal, Nemergut, Gabriel, Žoldák, Jonas V, Schaefer, Florian, Kast, Pavol, Miškovský, Andreas, Plückthun, Erik, Sedlák
Publikováno v:
Protein science : a publication of the Protein Society. 26(11)
Monoclonal antibodies of the immunoglobulin G (IgG) type have become mainstream therapeutics for the treatment of many life‐threatening diseases. For their successful application in the clinic and a favorable cost‐benefit ratio, the design and fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::d51be010aed882a90ce74b952d53f739
https://pubmed.ncbi.nlm.nih.gov/28833802
https://pubmed.ncbi.nlm.nih.gov/28833802