Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Florian Küllmer"'
Autor:
Chikako Nakajima, Masato Sawada, Erika Umeda, Yuma Takagi, Norihiko Nakashima, Kazuya Kuboyama, Naoko Kaneko, Satoaki Yamamoto, Haruno Nakamura, Naoki Shimada, Koichiro Nakamura, Kumiko Matsuno, Shoji Uesugi, Nynke A. Vepřek, Florian Küllmer, Veselin Nasufović, Hironobu Uchiyama, Masaru Nakada, Yuji Otsuka, Yasuyuki Ito, Vicente Herranz-Pérez, José Manuel García-Verdugo, Nobuhiko Ohno, Hans-Dieter Arndt, Dirk Trauner, Yasuhiko Tabata, Michihiro Igarashi, Kazunobu Sawamoto
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Axonal growth cones mediate axonal guidance and growth regulation. We show that migrating neurons in mice possess a growth cone at the tip of their leading process, similar to that of axons, in terms of the cytoskeletal dynamics and function
Externí odkaz:
https://doaj.org/article/eb78cdc0f8c54c43a0de1c4a96db4c3e
Publikováno v:
Organic & Biomolecular Chemistry. 20:4204-4214
Suitable designed photoswitches based on azobenzenes are essential structural features for photopharmacological compounds. Optimized azobenzenes are important for serving as building blocks in "azo extension" strategies, and for designing photodrugs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::495eaf75e290df4fb113f693cb1e2eed
https://doi.org/10.1039/d2ob00214k
https://doi.org/10.1039/d2ob00214k
Autor:
Veselin Nasufovic, Helmar Görls, Pierre Stallforth, Hans-Martin Dahse, Peter Bellstedt, Johanna Bößneck, Hans-Dieter Arndt, Florian Küllmer
Publikováno v:
Chemistry (Weinheim an Der Bergstrasse, Germany)
The first total synthesis of the actin‐stabilizing marine natural product geodiamolide H was achieved. Solid‐phase based peptide assembly paired with scalable stereoselective syntheses of polyketide building blocks and an optimized esterification
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6faf1f2126c52038f48523fcf075f33f
https://doi.org/10.1002/chem.202100989
https://doi.org/10.1002/chem.202100989
Autor:
Sabrina Pospich, Florian Küllmer, Alexander Belyy, Johanna Funk, Veselin Nasufovic, Hans-Dieter Arndt, Stefan Raunser, Peter Bieling
Publikováno v:
Angewandte Chemie (International Ed. in English)
Actin is essential for key processes in all eukaryotic cells. Cellpermeable optojasps provide spatiotemporal control of the actin cytoskeleton, confining toxicity and potentially rendering F‐actin druggable by photopharmacology. Here, we report cry
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::622dfea5c2ca34fb29fb371f650a32aa
https://doi.org/10.1002/ange.202013193
https://doi.org/10.1002/ange.202013193
Autor:
Florian Küllmer, Nynke A. Vepřek, Malgorzata Borowiak, Veselin Nasufović, Sebastian Barutzki, Oliver Thorn‐Seshold, Hans‐Dieter Arndt, Dirk Trauner
The natural product jasplakinolide is a widely used tool compound to stabilize F-actin and influence actin dynamics. We have previously introduced photoswitchable jasplakinolides (optojasps) that are activated with violet light and deactivated with b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08e7d4d074666e8d0c06a27b47c34438
https://doi.org/10.1101/2022.02.21.480923
https://doi.org/10.1101/2022.02.21.480923
Autor:
Tim P Ofman, Florian Küllmer, Jeroen D. C. Codée, Gijsbert A. van der Marel, Herman S. Overkleeft
Publikováno v:
Organic Letters
Organic Letters, 23(24), 9516-9519
Organic Letters, 23(24), 9516-9519
Cyclophellitols are potent inhibitors of exo- and endoglycosidases. Efficient synthetic methodologies are needed to fully capitalize on this intriguing class of mechanism-based enzyme deactivators. We report the synthesis of an orthogonally protected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::21fd5e66fdcfe8ada48833f5902383f3
https://hdl.handle.net/1887/3248633
https://hdl.handle.net/1887/3248633
Autor:
Dirk Trauner, Florian Küllmer, Veselin Nasufovic, Oliver Thorn-Seshold, Florian A. Gegenfurtner, Malgorzata Borowiak, Sebastian Peil, Hans-Dieter Arndt, Stefan Zahler
Publikováno v:
J Am Chem Soc
The spatiotemporally-controlled perturbation of cellular function using photopharmacology has facilitated the elucidation of biological networks and opens up new opportunities for precision medicine. Here, we introduce cell- permeable photoswitchable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6cb369665c451fcadd89fe4a1039ced
https://europepmc.org/articles/PMC8023282/
https://europepmc.org/articles/PMC8023282/
Autor:
Florian Küllmer, Stefan Raunser, Peter Bieling, Hans-Dieter Arndt, Felipe Merino, Sabrina Pospich, Thorsten Wagner, Johanna Funk
Publikováno v:
Nature Structural & Molecular Biology. 25:528-537
The function of actin is coupled to the nucleotide bound to its active site. ATP hydrolysis is activated during polymerization; a delay between hydrolysis and inorganic phosphate (Pi) release results in a gradient of ATP, ADP–Pi and ADP along actin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d97815366b7f7e3bcd2a12c11be70d4
https://doi.org/10.1038/s41594-018-0074-0
https://doi.org/10.1038/s41594-018-0074-0