Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Florian J Groelly"'
Autor:
Florian J Groelly, Manuela Porru, Jutta Zimmer, Hugo Benainous, Yanti De Visser, Anastasiya A Kosova, Serena Di Vito, Violeta Serra, Anderson Ryan, Carlo Leonetti, Alejandra Bruna, Annamaria Biroccio, Madalena Tarsounas
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 3, Pp n/a-n/a (2022)
Abstract The cells with compromised BRCA1 or BRCA2 (BRCA1/2) function accumulate stalled replication forks, which leads to replication‐associated DNA damage and genomic instability, a signature of BRCA1/2‐mutated tumours. Targeted therapies again
Externí odkaz:
https://doaj.org/article/02c619b0acf544c3b51f32c37322ca42
Autor:
Florian J. Groelly, Rebecca A. Dagg, Jonathan Mailler, Thanos D. Halazonetis, Madalena Tarsounas
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 101970- (2023)
Summary: Cells experiencing DNA replication stress enter mitosis with under-replicated DNA, which activates a repair mechanism known as mitotic DNA synthesis (MiDAS). Here we describe a protocol to identify at genome wide and at high resolution the g
Externí odkaz:
https://doaj.org/article/474a7216b26e4b8d9a849050a8924633
Publikováno v:
Nature Reviews Cancer. 23:78-94
A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells
Autor:
Florian J. Groelly, Emilia Puig Lombardi, Rebecca A. Dagg, Gijs Zonderland, Thanos D. Halazonetis, Benjamin Wright, Eliana M.C. Tacconi, Giacomo G. Rossetti, Sonia Barroso, Madalena Tarsounas, Helen Lockstone, Andrés Aguilera
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
Nature Communications
idUS. Depósito de Investigación de la Universidad de Sevilla
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
instname
Nature Communications
idUS. Depósito de Investigación de la Universidad de Sevilla
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
BRCA1 or BRCA2 germline mutations predispose to breast, ovarian and other cancers. High-throughput sequencing of tumour genomes revealed that oncogene amplification and BRCA1/2 mutations are mutually exclusive in cancer, however the molecular mechani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cdfd74eb2978ae343548a465b4255ae
http://hdl.handle.net/10261/259102
http://hdl.handle.net/10261/259102
Publikováno v:
Molecular Cell
Summary Cancer immunotherapies enhance anti-tumor immune responses using checkpoint inhibitors, such as PD-1 or PD-L1 inhibitors. Recent studies, however, have extended the scope of immunotherapeutics by unveiling DNA damage-induced innate immunity a
Autor:
Adrian L. Harris, Helen Lockstone, Timo Reisländer, Madalena Tarsounas, Benjamin Wright, Emilia Puig Lombardi, Florian J. Groelly, Ana Miar, Manuela Porru, Annamaria Biroccio, Arturo Londoño-Vallejo
Heterozygous germline mutations in BRCA2 predispose to breast and ovarian cancer. Contrary to non-cancerous cells, where BRCA2 deletion causes cell cycle arrest or cell death, BRCA2 inactivation in tumors is associated with uncontrolled cell prolifer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f4a2e911674957b99a890d18390d76f
A transcription-based mechanism for oncogenic β-catenin-induced lethality in BRCA1/2-deficient cells
Autor:
Rebecca A. Dagg, Gijs Zonderland, Emilia Puig Lombardi, Giacomo G. Rossetti, Florian J. Groelly, Sonia Barroso, Eliana M. C. Tacconi, Benjamin Wright, Helen Lockstone, Andrés Aguilera, Thanos D. Halazonetis, Madalena Tarsounas
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Germline mutations in BRCA1 or BRCA2 tumour suppressor genes predispose to different cancers, as does oncogene activation. Here the authors reveal that aberrant transcription of specific genes triggered by activation of the oncogene β-catenin causes
Externí odkaz:
https://doaj.org/article/df2c21948aa4474d8a16c5c108679eec
Autor:
Timo Reisländer, Emilia Puig Lombardi, Florian J. Groelly, Ana Miar, Manuela Porru, Serena Di Vito, Benjamin Wright, Helen Lockstone, Annamaria Biroccio, Adrian Harris, Arturo Londoño-Vallejo, Madalena Tarsounas
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
BRCA2 plays important roles in cell physiology by promoting DNA replication and DNA double-strand breaks repair. Here the authors, reveal the impact of BRCA2 depletion on the cell transcriptional program with activation of the innate immune response
Externí odkaz:
https://doaj.org/article/a4c12a795f2a4463a4d0d639093cc868