Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Florian I Schmidt"'
Autor:
Damien Bertheloot, Carlos WS Wanderley, Ayda H Schneider, Lisa DJ Schiffelers, Jennifer D Wuerth, Jan MP Tödtmann, Salie Maasewerd, Ibrahim Hawwari, Fraser Duthie, Cornelia Rohland, Lucas S Ribeiro, Lea‐Marie Jenster, Nathalia Rosero, Yonas M Tesfamariam, Fernando Q Cunha, Florian I Schmidt, Bernardo S Franklin
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 6, Pp 1-19 (2022)
Abstract Inflammasomes sense intracellular clues of infection, damage, or metabolic imbalances. Activated inflammasome sensors polymerize the adaptor ASC into micron‐sized “specks” to maximize caspase‐1 activation and the maturation of IL‐1
Externí odkaz:
https://doaj.org/article/c80e9b1804f64a2f89cb019c3eee47e4
Autor:
Matthew S J Mangan, Friederike Gorki, Karoline Krause, Alexander Heinz, Anne Pankow, Thomas Ebert, Dieter Jahn, Karsten Hiller, Veit Hornung, Marcus Maurer, Florian I Schmidt, Ralf Gerhard, Eicke Latz
Publikováno v:
PLoS Biology, Vol 20, Iss 11, p e3001351 (2022)
Pyrin is a cytosolic immune sensor that nucleates an inflammasome in response to inhibition of RhoA by bacterial virulence factors, triggering the release of inflammatory cytokines, including IL-1β. Gain-of-function mutations in the MEFV gene encodi
Externí odkaz:
https://doaj.org/article/d2b24fda68f24955ab6c72841f51a496
Autor:
Carlos Ramirez Alvarez, Carmon Kee, Ashwini Kumar Sharma, Leonie Thomas, Florian I Schmidt, Megan L Stanifer, Steeve Boulant, Carl Herrmann
Publikováno v:
PLoS Pathogens, Vol 17, Iss 6, p e1009687 (2021)
COVID-19 outbreak is the biggest threat to human health in recent history. Currently, there are over 1.5 million related deaths and 75 million people infected around the world (as of 22/12/2020). The identification of virulence factors which determin
Externí odkaz:
https://doaj.org/article/11b86d0dada54805bbef5683b91fa35a
Autor:
Matteo Bosso, Caterina Prelli Bozzo, Dominik Hotter, Meta Volcic, Christina M Stürzel, Annika Rammelt, Yi Ni, Stephan Urban, Miriam Becker, Mario Schelhaas, Sabine Wittmann, Maria H Christensen, Florian I Schmidt, Thomas Gramberg, Konstantin M J Sparrer, Daniel Sauter, Frank Kirchhoff
Publikováno v:
PLoS Pathogens, Vol 16, Iss 8, p e1008752 (2020)
Members of the family of pyrin and HIN domain containing (PYHIN) proteins play an emerging role in innate immunity. While absent in melanoma 2 (AIM2) acts a cytosolic sensor of non-self DNA and plays a key role in inflammasome assembly, the γ-interf
Externí odkaz:
https://doaj.org/article/d0e102ecfa314249b001ab0c86014b21
Autor:
Jan N Hansen, Fabian Kaiser, Christina Klausen, Birthe Stüven, Raymond Chong, Wolfgang Bönigk, David U Mick, Andreas Möglich, Nathalie Jurisch-Yaksi, Florian I Schmidt, Dagmar Wachten
Publikováno v:
eLife, Vol 9 (2020)
Compartmentalization of cellular signaling forms the molecular basis of cellular behavior. The primary cilium constitutes a subcellular compartment that orchestrates signal transduction independent from the cell body. Ciliary dysfunction causes sever
Externí odkaz:
https://doaj.org/article/586315dafc5549b09a3829c5629e34cd
Autor:
Fikadu G Tafesse, Ali Rashidfarrokhi, Florian I Schmidt, Elizaveta Freinkman, Stephanie Dougan, Michael Dougan, Alexandre Esteban, Takeshi Maruyama, Karin Strijbis, Hidde L Ploegh
Publikováno v:
PLoS Pathogens, Vol 11, Iss 10, p e1005188 (2015)
The ability of phagocytes to clear pathogens is an essential attribute of the innate immune response. The role of signaling lipid molecules such as phosphoinositides is well established, but the role of membrane sphingolipids in phagocytosis is large
Externí odkaz:
https://doaj.org/article/4263f524276e4c78800624d05e8bce7c
Autor:
Lisa D.J. Schiffelers, Sabine Normann, Sophie C. Binder, Elena Hagelauer, Anja Kopp, Assaf Alon, Matthias Geyer, Hidde L. Ploegh, Florian I. Schmidt
Activation of various inflammasomes converges on the cleavage of gasdermin D (GSDMD) by pro-inflammatory caspases, followed by oligomerization of the N-terminal domain (GSDMDNT) and the assembly of pores penetrating target membranes. Yet, it remained
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::373e5086a2888f1279605f5ddb9e3c44
https://doi.org/10.1101/2023.04.20.537718
https://doi.org/10.1101/2023.04.20.537718
Autor:
Anja Kopp, Gregor Hagelueken, Isabell Jamitzky, Jonas Moecking, Lisa D. J. Schiffelers, Florian I. Schmidt, Matthias Geyer
Gasdermin D (GSDMD) is a key mediator of pyroptosis, a pro-inflammatory form of cell death occurring downstream of inflammasome activation as part of the innate immune defence. Upon cleavage by inflammatory caspases, the N-terminal domain of GSDMD fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9fc04c66198c079f8d55ea199cdc79ed
https://doi.org/10.1101/2023.04.20.537705
https://doi.org/10.1101/2023.04.20.537705
Autor:
Yuta Tsukamoto, Takahiro Hiono, Shintaro Yamada, Keita Matsuno, Aileen Faist, Tobias Claff, Jianyu Hou, Vigneshwaran Namasivayam, Anja vom Hemdt, Satoko Sugimoto, Jin Ying Ng, Maria H. Christensen, Yonas M. Tesfamariam, Steven Wolter, Stefan Juranek, Thomas Zillinger, Stefan Bauer, Takatsugu Hirokawa, Florian I. Schmidt, Georg Kochs, Masayuki Shimojima, Yi-Shuian Huang, Andreas Pichlmair, Beate M. Kümmerer, Yoshihiro Sakoda, Martin Schlee, Linda Brunotte, Christa E. Müller, Manabu Igarashi, Hiroki Kato
Publikováno v:
Tsukamoto, Y, Hiono, T, Yamada, S, Matsuno, K, Faist, A, Claff, T, Hou, J, Namasivayam, V, vom Hemdt, A, Sugimoto, S, Ng, J Y, Christensen, M H, Tesfamariam, Y M, Wolter, S, Juranek, S, Zillinger, T, Bauer, S, Hirokawa, T, Schmidt, F I, Kochs, G, Shimojima, M, Huang, Y S, Pichlmair, A, Kümmerer, B M, Sakoda, Y, Schlee, M, Brunotte, L, Müller, C E, Igarashi, M & Kato, H 2023, ' Inhibition of cellular RNA methyltransferase abrogates influenza virus capping and replication ', Science, vol. 379, no. 6632, pp. 586-591 . https://doi.org/10.1126/science.add0875
Orthomyxo- and bunyaviruses steal the 5′ cap portion of host RNAs to prime their own transcription in a process called “cap snatching.” We report that RNA modification of the cap portion by host 2′-O-ribose methyltransferase 1 (MTr1) is essen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22ca613036512c6c980ca13774bda357
https://pure.au.dk/portal/da/publications/inhibition-of-cellular-rna-methyltransferase-abrogates-influenza-virus-capping-and-replication(e57afff0-1209-4d3e-92f4-f592420aad55).html
https://pure.au.dk/portal/da/publications/inhibition-of-cellular-rna-methyltransferase-abrogates-influenza-virus-capping-and-replication(e57afff0-1209-4d3e-92f4-f592420aad55).html
Autor:
Kim S. ROBINSON, Gee Ann TOH, Muhammad Jasrie FIRDAUS, Khek Chian THAM, Pritisha ROZARIO, Chrissie LIM, Ying Xiu TOH, Zhi Heng LAU, Sophie Charlotte BINDER, Jacob MAYER, Carine BONNARD, Florian I. SCHMIDT, John E. A. COMMON, Franklin L. ZHONG
NLRP1 is an innate immune sensor protein that activates inflammasome-driven pyroptotic cell death. Recent work demonstrates that human NLRP1 has evolved to sense viral infections. Whether and how human NLRP1 responds to other infectious agents is unc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad76428c5948ff4f0a10289c3b7465b3
https://doi.org/10.1101/2023.01.16.524188
https://doi.org/10.1101/2023.01.16.524188