Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Florian Hubrich"'
Publikováno v:
CHIMIA, Vol 75, Iss 6, Pp 543-547 (2021)
Nature has evolved a remarkable array of biosynthetic enzymes that install diverse chemistries into natural products (NPs), bestowing them with a range of important biological properties that are of considerable therapeutic value. This is epitomized
Externí odkaz:
https://doaj.org/article/02ad6c2fb4ec41cba548a11ea785fadc
Autor:
Thomas A. Scott, Marjan Verest, Jakob Farnung, Clarissa C. Forneris, Serina L. Robinson, Xinjian Ji, Florian Hubrich, Clara Chepkirui, Daniel U. Richter, Stefanie Huber, Philipp Rust, Alena B. Streiff, Qi Zhang, Jeffrey W. Bode, Jörn Piel
Publikováno v:
Chem, 8 (10)
β-Amino residues are regarded as extremely rare features among ribosomal products. They can be installed by a remarkable non-canonical enzymatic splicing process occurring in some Nif11-type ribosomally synthesized and posttranslationally modified p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fddd4bd2c294c8e54a752eb14b923d0d
https://hdl.handle.net/20.500.11850/578198
https://hdl.handle.net/20.500.11850/578198
Autor:
Florian Hubrich, Nina M. Bösch, Clara Chepkirui, Brandon I. Morinaka, Michael Rust, Muriel Gugger, Serina L. Robinson, Anna L. Vagstad, Jörn Piel
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2022, 119 (3), pp.e2113120119. ⟨10.1073/pnas.2113120119⟩
Proceedings of the National Academy of Sciences of the United States of America, 119 (3)
Proceedings of the National Academy of Sciences of the United States of America, 2022, 119 (3), pp.e2113120119. ⟨10.1073/pnas.2113120119⟩
Proceedings of the National Academy of Sciences of the United States of America, 119 (3)
Lipopeptides represent a large group of microbial natural products that include important antibacterial and antifungal drugs and some of the most-powerful known biosurfactants. The vast majority of lipopeptides comprise cyclic peptide backbones N-ter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3cea5b8312c7e0ddec3cf69342099c
https://hal-pasteur.archives-ouvertes.fr/pasteur-03526529/document
https://hal-pasteur.archives-ouvertes.fr/pasteur-03526529/document
Publikováno v:
Chemical Communications, 57 (20)
Chorismate and isochorismate represent an important branching point connecting primary and secondary metabolism in bacteria, fungi, archaea and plants. Chorismate- and isochorismate-converting enzymes are potential targets for new bioactive compounds
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c6d71b5c7734cda291aa8af6ae45aed
https://hdl.handle.net/20.500.11850/475204
https://hdl.handle.net/20.500.11850/475204
Publikováno v:
CHIMIA, Vol 75, Iss 6, Pp 543-547 (2021)
Chimia, 75 (6)
Chimia, 75 (6)
Nature has evolved a remarkable array of biosynthetic enzymes that install diverse chemistries into natural products (NPs), bestowing them with a range of important biological properties that are of considerable therapeutic value. This is epitomized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::edf27157dc4fde6eb80001111791ea9b
Autor:
Mads J Grüninger, Florian Hubrich, Jennifer N. Andexer, Silja Mordhorst, Michael Müller, Patrick Strack, Jürgen Pleiss, Patrick C. F. Buchholz
Publikováno v:
Organicbiomolecular chemistry. 17(8)
Chorismatases catalyse the cleavage of chorismate, yielding (dihydroxy-)benzoate derivatives, which often constitute starter units for pharmaceutically relevant secondary metabolites. Depending on their products, chorismatases have been classified in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c331119b8298ef92a61580d4149702dd
https://pubmed.ncbi.nlm.nih.gov/30706936
https://pubmed.ncbi.nlm.nih.gov/30706936
Autor:
Michael Müller, Jennifer N. Andexer, Puneet Juneja, Wolfram Welte, Florian Hubrich, Kay Diederichs
Publikováno v:
Journal of the American Chemical Society. 137(34)
Chorismatases are a class of chorismate-converting enzymes involved in the biosynthetic pathways of different natural products, many of them with interesting pharmaceutical characteristics. So far, three subfamilies of chorismatases are described tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d21177a9922f1bc354891a8f668263
https://pubmed.ncbi.nlm.nih.gov/26247872
https://pubmed.ncbi.nlm.nih.gov/26247872
Publikováno v:
Journal of biotechnology. 191
Combining the isochorismate synthase EntC and the chorismatase FkbO in a sequential enzyme cascade provides a useful system for the biocatalytic production and subsequent purification of isochorismate from an isochorismate/chorismate mixture. FkbO ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::894a84944fb88dce3b566a2ec6299c53
https://pubmed.ncbi.nlm.nih.gov/24915130
https://pubmed.ncbi.nlm.nih.gov/24915130
Publikováno v:
Journal of molecular biology. 426(1)
Chorismate-converting enzymes are involved in many biosynthetic pathways leading to natural products and can often be used as tools for the synthesis of chemical building blocks. Chorismatases such as FkbO from Streptomyces species catalyse the hydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18434994b682ac1fa5ea59fd7c57f2f0
https://pubmed.ncbi.nlm.nih.gov/24036425
https://pubmed.ncbi.nlm.nih.gov/24036425
Publikováno v:
Bioorganicmedicinal chemistry letters. 23(5)
Chorismatases and isochorismatases catalyse the hydrolysis of chorismate or isochorismate leading to unsaturated cyclohexenoic acid derivatives. Based on simplification of the physiological substrates, two cinnamic acid-derived compounds, differing i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d08f847904c5ec2f092812a9b4ebdec
https://pubmed.ncbi.nlm.nih.gov/23380376
https://pubmed.ncbi.nlm.nih.gov/23380376