Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Florian Guibbal"'
Autor:
Chung Ying Chan, Samantha L. Hopkins, Florian Guibbal, Anna Pacelli, Julia Baguña Torres, Michael Mosley, Doreen Lau, Patrick Isenegger, Zijun Chen, Thomas C. Wilson, Gemma Dias, Rebekka Hueting, Véronique Gouverneur, Bart Cornelissen
Publikováno v:
EJNMMI Research, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Purpose Radiopharmaceuticals targeting poly(ADP-ribose) polymerase (PARP) have emerged as promising agents for cancer diagnosis and therapy. PARP enzymes are expressed in both cancerous and normal tissue. Hence, the injected mass, molar acti
Externí odkaz:
https://doaj.org/article/4fdd5e6fe6fb4606aa18d95a3283dafa
Autor:
Thibault Gendron, Gianluca Destro, Natan J. W. Straathof, Jeroen B. I. Sap, Florian Guibbal, Charles Vriamont, Claire Caygill, John R. Atack, Andrew J. Watkins, Christopher Marshall, Rebekka Hueting, Corentin Warnier, Véronique Gouverneur, Matthew Tredwell
Publikováno v:
EJNMMI Radiopharmacy and Chemistry, Vol 7, Iss 1, Pp 1-11 (2022)
Abstract Background Flumazenil (FMZ) is a functionally silent imidazobenzodiazepine which binds to the benzodiazepine binding site of approximately 75% of the brain γ-aminobutyric acid-A receptors (GABAARs). Positron Emission Tomography (PET) imagin
Externí odkaz:
https://doaj.org/article/5341d4ac0ec2446bab32fb0383e7b523
Autor:
Gianluca Destro, Zijiun Chen, Chung Ying Chang, Claudia Fraser, Gemma Dias, Michael Mosley, Florian Guibbal, Veronique Gouverneur, Bart Cornelissen
Publikováno v:
Nuclear medicine and biology.
Introduction: Radioligand therapy (RLT) is an expanding field that has shown great potential in the fight against cancer. Radionuclides that can be carried by selective ligands such as antibodies, peptides, and small molecules targeting cancerous cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34edfc4c5df9411c838fb160ababc046
https://pubmed.ncbi.nlm.nih.gov/36621256
https://pubmed.ncbi.nlm.nih.gov/36621256
Autor:
Chung Ying Chan, Samantha L. Hopkins, Florian Guibbal, Anna Pacelli, Julia Baguña Torres, Michael Mosley, Doreen Lau, Patrick Isenegger, Zijun Chen, Thomas C. Wilson, Gemma Dias, Rebekka Hueting, Véronique Gouverneur, Bart Cornelissen
Publikováno v:
EJNMMI Research, 12(1):67. SpringerOpen
Purpose Radiopharmaceuticals targeting poly(ADP-ribose) polymerase (PARP) have emerged as promising agents for cancer diagnosis and therapy. PARP enzymes are expressed in both cancerous and normal tissue. Hence, the injected mass, molar activity and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8530527d93fa32ab8b1b8b932fd5d44
https://hdl.handle.net/11370/45f5503e-3d63-47bd-b701-60b0ecab70c4
https://hdl.handle.net/11370/45f5503e-3d63-47bd-b701-60b0ecab70c4
Autor:
Chung Ying Chan, Zijun Chen, Gianluca Destro, Mathew Veal, Doreen Lau, Edward O’Neill, Gemma Dias, Michael Mosley, Veerle Kersemans, Florian Guibbal, Véronique Gouverneur, Bart Cornelissen
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging, 49. SPRINGER
Purpose Rucaparib, an FDA-approved PARP inhibitor, is used as a single agent in maintenance therapy to provide promising treatment efficacy with an acceptable safety profile in various types of BRCA-mutated cancers. However, not all patients receive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a9867702c7d06988703ea7a9b05f44b
https://doi.org/10.1007/s00259-022-05835-4
https://doi.org/10.1007/s00259-022-05835-4
Autor:
Patrick G. Isenegger, Gemma M. Dias, Samantha L. Hopkins, Anna Pacelli, Chung Ying Chan, Bart Cornelissen, Véronique Gouverneur, Rebekka Hueting, Julia Baguña Torres, Michael Mosley, Florian Guibbal, Zijun Chen, Doreen Lau, Thomas C. Wilson
PurposeRadiopharmaceuticals targeting poly(ADP-ribose) polymerase (PARP) have emerged as promising agents for cancer diagnosis and therapy. PARP enzymes are expressed in both cancerous and normal tissue. Hence, the injected mass, molar activity and p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4414700e0777d3aa042793feb204e69c
https://doi.org/10.21203/rs.3.rs-1038375/v1
https://doi.org/10.21203/rs.3.rs-1038375/v1
Autor:
Gianluca Destro, Véronique Gouverneur, Florian Guibbal, Bart Cornelissen, Chung Ying Chan, Zijun Chen
The poly(ADP-ribose) polymerase (PARP) inhibitor rucaparib is used in the clinic to treatBRCA-mutated cancers. Herein, we report two strategies to access the18F-isotopologue of rucaparib by applying a copper-mediated nucleophilic18F-fluorodeboronatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95b4b893556df6b67b085833babf5f07
https://ora.ox.ac.uk/objects/uuid:41ef61b2-8851-4aed-9bfe-52a5847970d0
https://ora.ox.ac.uk/objects/uuid:41ef61b2-8851-4aed-9bfe-52a5847970d0
Autor:
Zijun, Chen, Gianluca, Destro, Florian, Guibbal, Chung Ying, Chan, Bart, Cornelissen, Véronique, Gouverneur
Publikováno v:
Organic letters. 23(18)
The poly(ADP-ribose) polymerase (PARP) inhibitor rucaparib is used in the clinic to treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c416f54a6badda8a9ed5f066f6c28600
https://pubmed.ncbi.nlm.nih.gov/34459606
https://pubmed.ncbi.nlm.nih.gov/34459606
Autor:
Emmanuelle Jestin, Fanny Gimié, Reuben Veerapen, Jennyfer Yong-Sang, Vincent Meneyrol, Olivier Meilhac, Imade Ait-Arsa, Bryan Veeren, Jessica Patche, Sébastien Bénard, Nicolas Diotel, Florian Guibbal, Ilya Khantalin
Publikováno v:
ACS Medicinal Chemistry Letters. 10:743-748
Atherosclerosis and its associated clinical complications are major health issues in industrialized countries. Lipoprotein-associated phospholipase A2 (Lp-PLA2) was demonstrated to play an important role in atherogenesis and to be a potential risk pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f71502b9b36f67ebef55288a23f586e2
https://doi.org/10.1021/acsmedchemlett.8b00643
https://doi.org/10.1021/acsmedchemlett.8b00643
Autor:
Véronique Gouverneur, Florian Guibbal, Thomas C. Wilson, Jeroen B. I. Sap, Long Lu, Qunchao Zhao, Qilong Shen, Patrick G. Isenegger
Herein, we report a mild and practical protocol for the copper-catalyzed chlorofluoromethylthiolation of (hetero)aryl boronic acids with the novel reagent PhSO2SCFClH. The resulting products are amenable to halogen exchange 18F-fluorination with cycl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be765c66861b468a9cd888c44d7e09a6
https://ora.ox.ac.uk/objects/uuid:4a7e3e8e-a93e-4bb6-abfa-01986c9517c7
https://ora.ox.ac.uk/objects/uuid:4a7e3e8e-a93e-4bb6-abfa-01986c9517c7